Patents by Inventor Jean-Cristophe Paillart

Jean-Cristophe Paillart has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Molecules which Bind to the Dimerization Initiation Site (DIS) of HIV RNA, Their Synthesis and Their Applications as Drugs
    Publication number: 20110118202
    Abstract: The dimerization of HIV RNA is a key step in the virus replication cycle. Based on RNA DIS crystal structures, a novel kind of compounds, dimeric or not, based on neamine was designed and synthesized. Biological studies showed that such compounds bind and interfere with the targeted RNA sequence, opening a new anti-HIV approach. The crystal structures and bio-chemical experiments showed that the DIS of HIV-1 genomic RNA is a target for new anti-HIV drugs and that those drugs could be derived from aminoglycosides. The results revealed that binding of aminoglycosides to the DIS is specific regarding both the aminoglycoside family and the RNA subtype.
    Type: Application
    Filed: March 23, 2007
    Publication date: May 19, 2011
    Inventors: Patrick Pale, Jean-Marc Weibel, Anne Bodlenner, Roland Marquet, Jean-Cristophe Paillart, Philippe Dumas, Eric Ennifar, Philippe Walter