Patents by Inventor Jean D. Sipe

Jean D. Sipe has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Ligand/anti-ligand assays for adherent proteins
    Patent number: 5536640
    Abstract: The present invention provides ligand/anti-ligand assays for detecting and/or measuring adherent proteins, including lipophilic serum or plasma proteins, such as serum amyloid A (SAA) and apolipoprotein Al (apoAl); cytokines such as IL-1 beta, IL-6, and TNF alpha; pentraxins, such as CRP; and globular serum or plasma proteins such as albumin.
    Type: Grant
    Filed: October 29, 1993
    Date of Patent: July 16, 1996
    Assignee: Trustees of Boston University
    Inventors: Jean D. Sipe, Greta Knapschaefer, Wayne A. Gonnerman, Carl Franzblau
  • Ligand/anti-ligand assays for adherent proteins
    Patent number: 5262303
    Abstract: The present invention provides ligand/anti-ligand assays for detecting and/or measuring adherent proteins, including lipophilic serum or plasma proteins, such as serum amyloid A (SAA) and apolipoprotein A1 (apoA1); cytokines such as IL-1 beta, IL-6, and TNF alpha; pentraxins, such as CRP; and globular serum or plasma proteins such as albumin.
    Type: Grant
    Filed: October 11, 1990
    Date of Patent: November 16, 1993
    Assignee: Trustees of Boston University
    Inventors: Jean D. Sipe, Greta Knapschaefer, Wayne A. Gonnerman, Carl Franzblau
  • Human prealbumin and related methods and products
    Patent number: 4816388
    Abstract: Recombinant human prealbumin and a method for producing such human prealbumin through recombinant DNA techniques including preparation and isolation of a cDNA sequence coding for human prealbumin, construction of a cloning vector and an expression vector containing said cDNA sequence, and expression of human prealbumin in a prokaryotic cell transformed by said expression vector are disclosed. The invention further relates to the use of human prealbumin cDNA in the diagnosis by hybridization methodologies of medical conditions with which variant forms of prealbumin are associated. Also disclosed is a method for diagnosing some Type I familial amyloid polyneuropathies by a restriction endonuclease assay with an enzyme which recognizes the nucleotide base sequence 5'-ATGCAT-3'.
    Type: Grant
    Filed: October 30, 1985
    Date of Patent: March 28, 1989
    Assignee: Children's Medical Center Corporation
    Inventors: Jean D. Sipe, Alexander S. Whitehead, Alan S. Cohen, Martha Skinner