Patents by Inventor Jean de Silva Correia

Jean de Silva Correia has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Polypeptides that Bind TRAIL-R1 and TRAIL-R2
    Publication number: 20120021995
    Abstract: Agonists for TRAIL death receptors including polypeptides that bind to TRAIL death receptor TRAIL-R1 (DR4) and/or TRAIL-R2 (DR5) and optionally having a multimerizing, e.g. trimerizing domain. Agonists are described that do not bind to TRAIL decoy receptors. The multimerizing domain may be derived from human tetranectin. The agonists can induce apoptosis in pathogenic cells expressing a TRAIL death receptor. Pharmaceutical compositions are described for treating diseases associated with cells expressing DR4 and DR5, such as tumor cells. Methods for selecting polypeptides and preparing multimeric complexes.
    Type: Application
    Filed: July 26, 2011
    Publication date: January 26, 2012
    Applicant: ANAPHORE, INC.
    Inventors: Katherine Bowdish, Anke Kretz-Rommel, Mark Renshaw, Bing Lin, Jean de Silva Correia, Roger Ferrini, Elise Chen