Abstract: An active implantable stimulating device (10) includes: (a) a tissue coupling unit (40) for being implanted directly onto a vagus nerve (Vn) of a patient, (b) an EEG-unit (70) for measuring an electroencephalogram of the patient, (c) an encapsulation unit (50) configured for being subcutaneously implanted, (d) an energy transfer lead (30) for transferring pulses of electrical and/or optical energy, (e) a signal transfer lead (60) for transferring signals between the EEG unit and the encapsulation unit. EEG electrodes (70a-70d) monitor the electric activity of the brain of a patient. The EEG signal is conveyed to the electronic circuit (53) in the form of EEG conditioned data. The electronic circuit analyses the EEG conditioned data to yield analysis results. The electronic circuit takes a decision to trigger energy pulses to stimulate the vagus nerve (VN).

Abstract: An active implantable stimulating device (10) includes: (a) a tissue coupling unit (40) for being implanted directly onto a vagus nerve (Vn) of a patient, (b) an EEG-unit (70) for measuring an electroencephalogram of the patient, (c) an encapsulation unit (50) configured for being subcutaneously implanted, (d) an energy transfer lead (30) for transferring pulses of electrical and/or optical energy, (e) a signal transfer lead (60) for transferring signals between the EEG unit and the encapsulation unit. EEG electrodes (70a-70d) monitor the electric activity of the brain of a patient. The EEG signal is conveyed to the electronic circuit (53) in the form of EEG conditioned data. The electronic circuit analyses the EEG conditioned data to yield analysis results. The electronic circuit takes a decision to trigger energy pulses to stimulate the vagus nerve (VN).

Abstract: According to a first aspect, the invention relates to a device (10) for electrochemically releasing a composition and comprising: one working electrode (30) comprising an electroactive conjugated polymer (40) containing or doped with said composition, a counter electrode (50), and a reference electrode (60). The device (10) is characterized in that it comprises electrical means (95, 100; 320; 165, 180) connected to the working electrode (30) and to the counter electrode (50) for obtaining at said working electrode (30) at least one composition releasing sequence (65) with respect to said reference electrode (60), each composition releasing sequence (65) comprising: a first voltametric pulse (70), followed by a rest period (80) during which no current is able to flow through said working electrode (30), followed by a second voltametric pulse (90), followed by an intermediate period (160) during which no current is able to flow through said working electrode (30).

Abstract: According to a first aspect, the invention relates to a device (10) for electrochemically releasing a composition and comprising: one working electrode (30) comprising an electroactive conjugated polymer (40) containing or doped with said composition, a counter electrode (50), and a reference electrode (60). The device (10) is characterized in that it comprises electrical means (95, 100; 320; 165, 180) connected to the working electrode (30) and to the counter electrode (50) for obtaining at said working electrode (30) at least one composition releasing sequence (65) with respect to said reference electrode (60), each composition releasing sequence (65) comprising: a first voltametric pulse (70), followed by a rest period (80) during which no current is able to flow through said working electrode (30), followed by a second voltametric pulse (90), followed by an intermediate period (160) during which no current is able to flow through said working electrode (30).

Abstract: The present invention relates to an electrode (30,30?) for implantation in contact with a neural tissue, said electrode extending along an axis, said neural tissue being capable of generating one or more action potentials, and said one or more action potentials propagating with a given speed in said neural tissue. The electrode comprises a carrier (31, 31?) of biocompatible electrically insulating material; stimulation electrode contacts (32a; 32?a; 32b; 32?b) deposited on a surface of said carrier (31, 31?) for applying an electrical stimulation to said neural tissue so as to generate, after a given latency time, a compound action potential when stimulated by said electrical stimulation; one or more sensing electrode contacts (33a; 33b; 33c; 33?a; 33?b; 33?c) deposited on said surface of said carrier and provided at a distance from said stimulation electrode contacts, said sensing electrode contacts being adapted to be connected to measuring means (23) having a given inactive period.

Abstract: The present invention relates to an electrode (30,30?) for implantation in contact with a neural tissue, said electrode extending along an axis, said neural tissue being capable of generating one or more action potentials, and said one or more action potentials propagating with a given speed in said neural tissue. The electrode comprises a carrier (31, 31?) of biocompatible electrically insulating material; stimulation electrode contacts (32a; 32?a; 32b; 32?b) deposited on a surface of said carrier (31, 31?) for applying an electrical stimulation to said neural tissue so as to generate, after a given latency time, a compound action potential when stimulated by said electrical stimulation; one or more sensing electrode contacts (33a; 33b; 33c; 33?a; 33?b; 33?c) deposited on said surface of said carrier and provided at a distance from said stimulation electrode contacts, said sensing electrode contacts being adapted to be connected to measuring means (23) having a given inactive period.

Abstract: The present invention relates to an electrode (30,30?) for implantation in contact with a neural tissue, said electrode extending along an axis, said neural tissue being capable of generating one or more action potentials, and said one or more action potentials propagating with a given speed in said neural tissue. The electrode comprises a carrier (31, 31?) of biocompatible electrically insulating material; stimulation electrode contacts (32a; 32?a; 32b; 32?b) deposited on a surface of said carrier (31, 31?) for applying an electrical stimulation to said neural tissue so as to generate, after a given latency time, a compound action potential when stimulated by said electrical stimulation; one or more sensing electrode contacts (33a; 33b; 33c; 33?a; 33?b; 33?c) deposited on said surface of said carrier and provided at a distance from said stimulation electrode contacts, said sensing electrode contacts being adapted to be connected to measuring means (23) having a given inactive period.

Abstract: According to a first aspect, the invention relates to a device (10) for electrochemically releasing a composition and comprising: one working electrode (30) comprising an electroactive conjugated polymer (40) containing or doped with said composition, a counter electrode (50), and a reference electrode (60). The device (10) is characterized in that it comprises electrical means (95, 100; 320; 165, 180) connected to the working electrode (30) and to the counter electrode (50) for obtaining at said working electrode (30) at least one composition releasing sequence (65) with respect to said reference electrode (60), each composition releasing sequence (65) comprising: a first voltametric pulse (70), followed by a rest period (80) during which no current is able to flow through said working electrode (30), followed by a second voltametric pulse (90), followed by an intermediate period (160) during which no current is able to flow through said working electrode (30).

Abstract: The present invention relates to a nanowire array (15, 16) for electrically-controlled elution of a therapeutic composition (5) comprising a plurality of nanoscopic-sized wires (12, 12), nanowires, attached to an electrically conducting solid support (7), said nanowires formed from electroactive conjugated polymer (4) containing or doped with said therapeutic composition (5) coated over a plurality of nanoscopic sized electrically conducting protrusions (8). It also relates to a method for preparing a nanowire array and an electrode.

Abstract: The present invention relates to an electrode (30,30?) for implantation in contact with a neural tissue, said electrode extending along an axis, said neural tissue being capable of generating one or more action potentials, and said one or more action potentials propagating with a given speed in said neural tissue. The electrode comprises a carrier (31, 31?) of biocompatible electrically insulating material; stimulation electrode contacts (32a; 32?a; 32b; 32?b) deposited on a surface of said carrier (31, 31?) for applying an electrical stimulation to said neural tissue so as to generate, after a given latency time, a compound action potential when stimulated by said electrical stimulation; one or more sensing electrode contacts (33a; 33b; 33c; 33?a; 33?b; 33?c) deposited on said surface of said carrier and provided at a distance from said stimulation electrode contacts, said sensing electrode contacts being adapted to be connected to measuring means (23) having a given inactive period.

Abstract: The present invention relates to a method and a device for visualising an image by electrical stimulation of functional parts of a visual system. A method according to the present invention comprises an image provision step for providing an image to be visualised by the visual system, a selection step for selecting, from a phosphene data file comprising a description of phosphenes and the stimuli characteristics needed for obtaining them, a number of most appropriate phosphenes to be generated for visualising the image, so that the image is transferred into a summation of patches of light, and a stimulation step for stimulating functional parts of the visual system so as to generate the selected phosphenes. This way, a pixel based image is converted into a plurality of patches of light. A device for carrying out the method is also described.