Abstract: A series of fused pentacyclic imidazole derivatives, being potent modulators of human TNFa activity, are accordingly of benefit in the treatment and/or prevention of various human ailments, including autoimmune and inflammatory disorders; neurological and neurodegenerative disorders; pain and nociceptive disorders; cardiovascular disorders; metabolic disorders; ocular disorders; and oncological disorders. In particular, the present invention is concerned with 6, 7-dihydro-7, 14-methanobenzimidazo[1, 2-b][2,5]benzodiazocin-5(14H)-one derivatives and analogs thereof.

Abstract: The mechanical cable control, including an automatic adjustment device (4, 5, 9/7) between a first portion (2) of the shielding conduit of the cable and an outer ferrule structure (6) comprises at least one electrical path mechanism (I; II) incorporating a pair of cooperating electrical contacts (12, 11; 12', 11'), attached to the outer ferrule structure (6) and, via a disengageable connection, to an extension of the first conduit portion (2). The cable control typically incorporates a pair of contacts (11, 12) for detecting the operation of the control and a pair of contacts (11'; 12') for indicating the wear of the component to be actuated (C) by the cable control.

Abstract: Mounted slideably on an outer connector structure (6), in which is received slideably an inner connector structure (5) having a toothed zone (8) for interaction with at least one locking member (13) mounted so as to be radially displaceable in the outer connector structure (6), is a tubular actuating member (14), on which bears an axially biasing spring (18) and which forms, together with the locking member (13), at least one pair of cooperating ramp surfaces (21, 23; 22, 24) controlling the radial displacement of the locking member (13).

Abstract: The locking device, situated between telescopic inner and outer ferrule structure (10, 12) of the cable conduit, consists of jaw structures (21) having external teeth (26) which cooperate with indentations (15) formed on an inside wall (14) of the outer ferrule structure (12), and internal ramp surfaces (27) which cooperate with a cam surface (11) formed on the inner ferrule structure (10). The jaws (21) are advantageously carried by a cage (16) connected to a control component (24) which is connected to the cable by frictional engagement.

Abstract: A device (210) for attaching to a wall (212) the end (214) of a sheath (216), in which a control cable (218) is slidably received, comprising a sheath end fitting (211) associated with said end and designed to be received in an aperture (220) provided in said wall, said sheath end being slidably received in an inner bore (226) of the end fitting, the latter being provided with locking means (230) for fixing the end of the sheath axially with respect to the end fitting after installation of the control cable, characterized in that it comprises an adjustment spring (56) bearing on said end fitting and urging said sheath end resiliently away from said wall when the cable is installed.

Abstract: The invention relates to a mechanical control by cable (10) sliding axially in a flexible sheath (12), equipped with an automatic adjustment device (40) for varying the length of the sheath as a function of the clearances appearing in the control, and of which one end (28) is connected to a receiving member (30) provided with elastic return means (36).

Abstract: A control arrangement is of the type comprising a control transmission chain which includes a cable (10), an actuating member such as a pedal (12) connected to one end (14) of the cable, and possibly a system of levers interposed between the other end (18) of the cable and a receiving member (28) such as a friction clutch, the flexible sheath being anchored in the vicinity of one of its ends (34) to a fixed part of a support structure (13). The end portion (36, 48) of said sheath in the vicinity of its other end (37) is mounted with the possibility of axial movement in a fixed support (38) which is fixed with respect to said support structure. A device (40) for momentary blocking of said axial movement is interposed between said end portion (36, 48) of the sheath and said fixed support (38), the blocking device (40) comprising a control member (74, 42) coupled to a point on said control transmission chain.