Patents by Inventor Jean-Denis DOCQUIER

Jean-Denis DOCQUIER has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • BETA-LACTAMASE VARIANTS
    Publication number: 20220356459
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
    Type: Application
    Filed: May 16, 2022
    Publication date: November 10, 2022
    Inventors: Jean De Gunzburg, Jean-Denis Docquier
  • ANTIBACTERIAL COMPOUNDS
    Publication number: 20220235059
    Abstract: The present invention relates to compounds of formula (I) their salts and derivatives. Further object of the present invention are compositions, which comprise at least one compound of formula (I) or its pharmaceutically acceptable salts and derivatives and excipients and, optionally, a further active compound. Further object of the present invention are compounds of formula (I) or compositions which comprise them for use as antibacterial agents.
    Type: Application
    Filed: June 4, 2020
    Publication date: July 28, 2022
    Applicant: Universita' degli Studi di Siena
    Inventors: Federico Corelli, Antonella Brizzi, Claudia Mugnaini, Jean-Denis Docquier, Filomena Sannio
  • Beta-lactamase variants
    Patent number: 11365403
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
    Type: Grant
    Filed: October 24, 2018
    Date of Patent: June 21, 2022
    Assignees: Da Volterra, Bioaster
    Inventors: Jean De Gunzburg, Jean-Denis Docquier
  • INHIBITORS OF METALLO-BETA-LACTAMASES
    Publication number: 20220000841
    Abstract: The present invention relates to new compounds that act as inhibitors of metallo-beta-lactamases (MBL). The present invention also relates to pharmaceutical compositions comprising such MBL inhibitors, and uses thereof in the treatment of bacterial infections. More generally, the present invention finds applications in any field wherein bacteria producing MBL must be removed.
    Type: Application
    Filed: November 15, 2019
    Publication date: January 6, 2022
    Inventors: JEAN-FRANÇOIS HERNANDEZ, LAURENT GAVARA, JEAN-DENIS DOCQUIER, LAURENT SEVAILLE, ALICE LEGRU
  • Beta-lactamase variants
    Patent number: 10988749
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 27, 2021
    Assignees: DA VOLTERRA, BIOASTER
    Inventors: Jean De Gunzburg, Jean-Denis Docquier
  • Beta-lactamase variants
    Patent number: 10982205
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a Verona integron-encoded metallo-?-lactamase (VIM-2) variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
    Type: Grant
    Filed: February 22, 2017
    Date of Patent: April 20, 2021
    Assignees: DA VOLTERRA, BIOASTER
    Inventors: Jean De Gunzburg, Jean-Denis Docquier
  • BETA-LACTAMASE VARIANTS
    Publication number: 20200318094
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
    Type: Application
    Filed: October 24, 2018
    Publication date: October 8, 2020
    Inventors: Jean De Gunzburg, Jean-Denis Docquier
  • BETA-LACTAMASE VARIANTS
    Publication number: 20190062719
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability, stability in intestinal medium, improved activity against one or more antibiotics, improved specific activity and/or improved production in a host cell.
    Type: Application
    Filed: February 22, 2017
    Publication date: February 28, 2019
    Inventors: Jean DE GUNZBURG, Jean-Denis DOCQUIER
  • BETA-LACTAMASE VARIANTS
    Publication number: 20190048331
    Abstract: The present invention relates to an isolated polypeptide having beta-lactamase activity and nucleic acid sequences encoding the polypeptide. The isolated polypeptide of the invention is a VIM-2 variant with improved properties such as improved protease stability.
    Type: Application
    Filed: February 22, 2017
    Publication date: February 14, 2019
    Applicants: DA VOLTERRA, BIOASTER
    Inventors: Jean DE GUNZBURG, Jean-Denis DOCQUIER
  • Macrocyclic amidinourea derivatives, methods of preparation and uses thereof as chitinase inhibitors
    Patent number: 10071975
    Abstract: The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
    Type: Grant
    Filed: June 18, 2014
    Date of Patent: September 11, 2018
    Assignee: CYGNET BIOSCIENCES B.V.
    Inventors: Stefania Sanfilippo, Brunella Posteraro, Maurizio Sanguinetti, Maurizio Botta, Giorgio Maccari, Filomena De Luca, Jean-Denis Docquier, Davide Deodato
  • Linear guanidine derivatives, methods of preparation and uses thereof
    Patent number: 10004702
    Abstract: The present invention relates to linear guanidine derivatives, methods of preparation, uses and pharmaceutical compositions thereof. The compounds of Formulas 1 or 2 exhibit high antimicrobial activity against Gram positive and Gram negative bacteria.
    Type: Grant
    Filed: October 9, 2015
    Date of Patent: June 26, 2018
    Assignee: LEAD DISCOVERY SIENA S.R.L.
    Inventors: Maurizio Botta, Giorgio Maccari, Stefania Sanfilippo, Filomena De Luca, Jean-Denis Docquier, Davide Deodato
  • LINEAR GUANIDINE DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF
    Publication number: 20170304235
    Abstract: The present invention relates to linear guanidine derivatives, methods of preparation, uses and pharmaceutical compositions thereof. The compounds of Formulas 1 or 2 exhibit high antimicrobial activity against Gram positive and Gram negative bacteria.
    Type: Application
    Filed: October 9, 2015
    Publication date: October 26, 2017
    Applicant: LEAD DISCOVERY SIENA S.R.L.
    Inventors: Maurizio BOTTA, Giorgio MACCARI, Stefania SANFILIPPO, Filomena DE LUCA, Jean-Denis DOCQUIER, Davide DEODATO
  • NEW MACROCYCLIC AMIDINOUREA DERIVATIVES, METHODS OF PREPARATION AND USES THEREOF AS CHITINASE INHIBITORS
    Publication number: 20160137617
    Abstract: The present invention relates to macrocyclic amidinourea derivatives of formula 8, methods of preparation and uses thereof, pharmaceutical compositions in particular to be used as chitinase inhibitors in the treatment of a fungal infection.
    Type: Application
    Filed: June 18, 2014
    Publication date: May 19, 2016
    Inventors: Stefania SANFILIPPO, Brunella POSTERARO, Maurizio SANGUINETTI, Maurizio BOTTA, Giorgio MACCARI, Filomena DE LUCA, Jean-Denis DOCQUIER, Davide DEODATO