Abstract: Reciprocating positive-displacement diaphragm pump (1) intended for liquids and for medical use, has a driving part (10) within which there are an electromagnetic actuator (11), incorporating at least one coil (12) and activating a piston (14) of a moving member (15) capable of cyclic linear motion. The pump comprises a pump body (20) within which there is a pre-loaded diaphragm (22) able to undergo a translational movement by elastic deformation from a normal rest position to an adjacent position through the transmission of the work from a piston (14). It incorporates a device (30) for detecting out-of-tolerance variations in the intensity of the supply current by measurements (33), a device (40) for continuously measuring the position of the moving member (15) and devices (30, 45) for processing and analyzing the measurements, which are able to generate at least one malfunctioning alarm signal (35) indicating the detection of at least one malfunction of the pump.

Abstract: A disposable cassette intended for a metering pump for infusion consisting of just two components, namely, a hollow first component (1) forming a pump body, and a second component (5) collaborating with the hollow first component (1) to form a pumping zone (6) and comprising a flexible part (10) characterized in that the second component (5) further comprises a rigid part (9) secured to the flexible part (10) and able to be assembled with the hollow first component (1). The invention also relates to a method for manufacturing such a disposable cassette.

Abstract: A disposable device for the continuous centrifugal separation of a physiological fluid includes: a fixed axial element; a centrifugation chamber that can rotate around the axis of the element; an inlet channel for the blood to be centrifuged, whose dispensing port is close to the base of the chamber; and an outlet passage for a separated constituent, whose inlet port is close to the other end of the chamber in a concentrated area of one of the separated constituents having the lowest mass density in order to remove it continuously. The chamber takes the form of a long tube. The fixed axial element includes a second outlet passage for a second separated constituent, whose inlet port is close to the end of the chamber opposite the base in a concentrated area of the second separated constituent having the highest mass density in order to remove it continuously.

Abstract: Reciprocating positive-displacement diaphragm pump (1) intended for liquids and for medical use, has a driving part (10) within which there are an electromagnetic actuator (11), incorporating at least one coil (12) and activating a piston (14) of a moving member (15) capable of cyclic linear motion. The pump comprises a pump body (20) within which there is a pre-loaded diaphragm (22) able to undergo a translational movement by elastic deformation from a normal rest position to an adjacent position through the transmission of the work from a piston (14). It incorporates a device (30) for detecting out-of-tolerance variations in the intensity of the supply current by measurements (33), a device (40) for continuously measuring the position of the moving member (15) and devices (30, 45) for processing and analyzing the measurements, which are able to generate at least one malfunctioning alarm signal (35) indicating the detection of at least one malfunction of the pump.

Abstract: A single-use pumping casing (A) includes an inlet duct (6), a delivery duct (7) and a alternating-movement pumping member (1a), and a driving mechanism including a member (4) for driving the pumping member (1a) in at least one of the alternating movements thereof. The driving mechanism is housed in a holder housing (B) having a wall with a retaining slideway (19) for engaging sliding members of the pumping casing (A), the housing further including a passage opening (21) for the driving member (4), an abutment (20) for determining the position of the pumping casing (A) along the retaining slideway (19) and for placing the pumping member (1a) into a drive relation with the driving member (4), and a removable attachment (19, 20) for attaching the pumping casing (A) in the determined position along the retaining slideway (19).

Abstract: A disposable cassette intended for a metering pump for infusion consisting of just two components, namely, a hollow first component (1) forming a pump body, and a second component (5) collaborating with the hollow first component (1) to form a pumping zone (6) and comprising a flexible part (10) characterized in that the second component (5) further comprises a rigid part (9) secured to the flexible part (10) and able to be assembled with the hollow first component (1). The invention also relates to a method for manufacturing such a disposable cassette.

Abstract: This pump comprises a chamber and an annular pumping diaphragm secured to the said chamber and the inner edge of which is secured to a central drive part. This diaphragm has a convex domed profile so that its expulsion stroke results essentially in the energy-generating flexing of the intake stroke. The rigidity of the diaphragm is chosen so that the absolute pressure of the chamber lies within the following range: Patm?(|?Pvalve—in|+|?P?h—in|+|?Ppd|)?P>Pvap where: Patm=atmospheric pressure, Pvap=vapour pressure of the pumped fluid, ?Pvalve—in=pressure difference between the upstream and downstream side of the inlet valve for opening it, ?P?h—in=pressure difference in the upstream pipe between its distal end and the upstream side of the inlet valve as a result of the weight of the column of fluid, ?Ppd=pressure drop in the upstream pipe for the desired flow rate.

Abstract: Centrifugation method and chamber for washing and continuous separation of blood constituents. This chamber comprises at least one first intake channel for the blood, at least one second intake channel for a sterile washing solution, at least one first outlet channel for at least one constituent of this blood, and at least one second outlet channel for a fluid composed of said washing solution and of the other blood constituents. The second intake channel has its downstream end continued on its periphery by a circular deflector. The latter extends into the bottom of the chamber and is terminated along its inner cylindrical side wall by a ridge, which defines a passage of annular cross section for the flow of said sterile washing solution.

Abstract: A disposable device for the continuous centrifugal separation of a physiological fluid includes: a fixed axial element; a centrifugation chamber that can rotate around the axis of the element; an inlet channel for the blood to be centrifuged, whose dispensing port is close to the base of the chamber; and an outlet passage for a separated constituent, whose inlet port is close to the other end of the chamber in a concentrated area of one of the separated constituents having the lowest mass density in order to remove it continuously. The chamber takes the form of a long tube. The fixed axial element includes a second outlet passage for a second separated constituent, whose inlet port is close to the end of the chamber opposite the base in a concentrated area of the second separated constituent having the highest mass density in order to remove it continuously.

Abstract: The invention relates to a centrifugation enclosure (1) made of rigid plastic that comprises a member (1b) adapted to engage with the driving organ of a centrifugation machine (M) and a communication member (5) between the enclosure (1) and the outside, made of rigid plastic and comprising un first duct (5a) extending therethrough for supplying said enclosure (1) as well as two ducts (5b, 5c) extending therethrough for discharging the separated components. A holder (3) made of rigid plastic and having a network of channels (4a, 4b, 4c) formed therein connects the ducts (5a, 5b, 5c), respectively, to supply (P1) and reception (P2, P3) tanks, with side sealing members (6) of said channel network (4a, 4b, 4c). The ends of the ducts (5a, 5b, 5c) are adjacent to the respective ends of the channels (4a, 4b, 4c), and the ends of the ducts (5a, 5b, 5c) have surfaces mating with the end surfaces of the respective channels (4a, 4b, 4c), said mating surfaces being connected to one another.

Abstract: A disposable device for centrifugation of blood is used for separating or also washing constituents of the blood includes a centrifugation chamber with a revolving shaft and an opening through which the shaft passes, a rotational guide, a rotational driver, and at least one static member for admission/evacuation engaged in the centrifugation chamber. This member includes at least one channel for intake of the blood and at least one outlet channel for one of its constituents, and at least one admission channel for a pressurized gaseous fluid which opens out inside the centrifugation chamber. A gap is formed in the opening between the centrifugation chamber and the static member and allows the gaseous fluid to escape from the centrifugation chamber.

Abstract: The invention relates to disposable device for the continuous centrifugal separation of a physiological fluid. The inventive device comprises: a fixed axial element; a centrifugation chamber which is mounted such that it can rotate around the axis of said element; an inlet channel for the blood to be centrifuged, the dispensing port of which is located close to the base of the chamber; and an outlet passage for a separated constituent, the inlet port of which is located close to the other end of the chamber in a concentrated area of one of the separated constituents having the lowest mass density in order for same to be removed continuously. The above-mentioned chamber takes the form of a long tube.

Abstract: This pump with a battery-powered drive device comprises a circular elastic diaphragm (1a) and two valves (2b, 10), which has a diameter of 3 to 25 mm and is subjected to a compressive prestress of between 1'104 and 4'104 Pa capable of enabling it to return to its rest position at a maximum working frequency of between 8 and 12 Hz with a travel of between 0.2 and 2 mm, corresponding to a maximum flow rate of 1.5 to 2.5 l/h. The drive device comprises an electromagnet (5) in direct contact with the diaphragm (1a), a standard power supply battery, the available energy of which is from 7000 to 10'000 J, means for analyzing the supply current for the electromagnet and for detecting, at each pumping drive cycle, a minimum defined intensity of the supply current corresponding to the closure of the gap of the electromagnet (5) and means for interrupting the supply current once this minimum intensity has been reached.

Abstract: The invention relates to a single-use pumping casing (A) provided with an inlet duct (6), a discharge duct (7) and a alternating-movement pumping member (1a), a driving mechanism including a member (4) for driving the pumping member (1a) in at least one of the alternating movements thereof. The driving mechanism is housed in a holder housing (B) having a wall with a retaining rail (19) for engaging sliding members of the pumping casing (A), the housing further including a passage opening (21) for the driving member (4), an abutment means (20) for determining the position of the pumping casing (A) along the retaining rail (19) and for placing the pumping member (1a) into a drive relation with the driving member (4), and a removable attachment means (19, 20) for attaching said pumping casing (A) in said determined position along the retaining rail (19).

Abstract: This pump with a battery-powered drive device comprises a circular elastic diaphragm (1a) and two valves (2b, 10), which has a diameter of 3 to 25 mm and is subjected to a compressive prestress of between 1? 104 and 4? 104 Pa capable of enabling it to return to its rest position at a maximum working frequency of between 8 and 12 Hz with a travel of between 0.2 and 2 mm, corresponding to a maximum flow rate of 1.5 to 2.5 l/h. The drive device comprises an electromagnet (5) in direct contact with the diaphragm (1a), a standard power supply battery, the available energy of which is from 7000 to 10'000 J, means for analyzing the supply current for the electromagnet and for detecting, at each pumping drive cycle, a minimum defined intensity of the supply current corresponding to the closure of the gap of the electromagnet (5) and means for interrupting the supply current once this minimum intensity has been reached.

Abstract: The invention relates to a centrifugation enclosure (1) made of rigid plastic that comprises a member (1b) adapted to engage with the driving organ of a centrifugation machine (M) and a communication member (5) between the enclosure (1) and the outside, made of rigid plastic and comprising an first duct (5a) extending therethrough for supplying said enclosure (1) as well as two ducts (5b, 5c) extending therethrough for discharging the separated components. A holder (3) made of rigid plastic and having a network of channels (4a, 4b, 4c) formed therein connects the ducts (5a, 5b, 5c), respectively, to supply (P1) and reception (P2, P3) tanks, with side sealing members (6) of said channel network (4a, 4b, 4c). The ends of the ducts (5a, 5b, 5c) are adjacent to the respective ends of the channels (4a, 4b, 4c), and the ends of the ducts (5a, 5b, 5c) have surfaces mating with the end surfaces of the respective channels (4a, 4b, 4c), said mating surfaces being connected to one another.

Abstract: One of the ends of this chamber has sealing means and is traversed by an intake channel for the blood that is to be centrifuged, and by at least one discharge channel). At least one circular deflector, concentric to the axis of revolution, is situated between the outlet of the intake channel and the admission port of the discharge channel in order to form an axial flow of the blood with a current counter to that formed against the lateral wall. This deflector has an alternating sequence of contiguous concave parts and convex parts that have or define between them crest lines or thalweg lines, at least some of these lines being inclined in the direction of the axis of revolution of the chamber.

Abstract: Centrifugation method and chamber for washing and continuous separation of blood constituents. This chamber comprises at least one first intake channel for the blood, at least one second intake channel for a sterile washing solution, at least one first outlet channel for at least one constituent of this blood, and at least one second outlet channel for a fluid composed of said washing solution and of the other blood constituents. The second intake channel has its downstream end continued on its periphery by a circular deflector. The latter extends into the bottom of the chamber and is terminated along its inner cylindrical side wall by a ridge, which defines a passage of annular cross section for the flow of said sterile washing solution.

Abstract: A disposable device for centrifugation of blood is used for separating or also washing constituents of the blood. This device comprises a centrifugation chamber with a revolving shaft and an opening through which the latter passes, rotational guide means, rotational drive means, and at least one static member for admission/evacuation engaged in the centrifugation chamber. This member comprises at least one channel for intake of the blood and at least one outlet channel for one of its constituents. The static member comprises at least one admission channel which is provided for a pressurized gaseous fluid and which opens out inside the centrifugation chamber. A gap is formed in said opening between the centrifugation chamber and the static member and allows said gaseous fluid to escape from this centrifugation chamber.

Abstract: The invention relates to disposable device for the continuous centrifugal separation of a physiological fluid. The inventive device comprises: a fixed axial element; a centrifugation chamber which is mounted such that it can rotate around the axis of said element; an inlet channel for the blood to be centrifuged, the dispensing port of which is located close to the base of the chamber; and an outlet passage for a separated constituent, the inlet port of which is located close to the other end of the chamber in a concentrated area of one of the separated constituents having the lowest mass density in order for same to be removed continuously. The above-mentioned chamber takes the form of a long tube.