Patents by Inventor Jean E. Schwarzbauer
Jean E. Schwarzbauer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220226543Abstract: A matrix for neuron regeneration. The matrix can include a sheet having a first surface and a second surface opposite the first surface, the second surface having a plurality of integrally formed ridges. The sheet can have a spiral shape, such that the first surface of the sheet faces the second surface of the sheet. The sheet and the integrally formed ridges can comprise oligo(poly(ethylene glycol) fumarate).Type: ApplicationFiled: April 30, 2020Publication date: July 21, 2022Inventors: Michael J. Yaszemski, Anthony J. Windebank, Ahad M. Siddiqui, James L. Herrick, Suzanne L. Glass, Alan L. Miller, II, Brian E. Waletzki, Nicolas N. Madigan, Jeffrey Schwartz, Jean E. Schwarzbauer, Kelly S. Lim, Stephen B. Bandini, Gregory M. Harris, Jeffrey W. Chen
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Patent number: 11364105Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional neural tissues for use in methods including regenerative medicine, wound repair and transplantation.Type: GrantFiled: October 5, 2016Date of Patent: June 21, 2022Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Jean E. Schwarzbauer, Casey M. Jones, Patrick E. Donnelly, Stephen B. Bandini, Shivani Singh
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Patent number: 10675138Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation.Type: GrantFiled: October 5, 2015Date of Patent: June 9, 2020Assignee: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Jean E. Schwarzbauer, Casey M. Jones, Patrick E. Donnelly, Stephen B. Bandini, Shivani Singh
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Patent number: 10563160Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair, and transplantation.Type: GrantFiled: December 6, 2012Date of Patent: February 18, 2020Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Jean E. Schwarzbauer, Casey M. Jones, Patrick E. Donnelly, Stephen B. Bandini, Shivani Singh
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Publication number: 20190380823Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional neural tissues for use in methods including regenerative medicine, wound repair and transplantation.Type: ApplicationFiled: October 5, 2016Publication date: December 19, 2019Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Jean E. Schwarzbauer, Casey M. Jones, Patrick E. Donnelly, Stephen B. Bandini, Shivani Singh
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Publication number: 20160128818Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair and transplantation.Type: ApplicationFiled: October 5, 2015Publication date: May 12, 2016Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Jean E. Schwarzbauer, Casey M. Jones, Patrick E. Donnelly, Stephen B. Bandini, Shivani Singh
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Publication number: 20140330392Abstract: The present invention provides tissue scaffolds, methods of generating such scaffolds, and methods of use of such scaffolds to generate aligned and functional tissues for use in methods including regenerative medicine, wound repair, and transplantation.Type: ApplicationFiled: December 6, 2012Publication date: November 6, 2014Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Jean E. Schwarzbauer, Casey M. Jones, Patrick E. Donnelly, Stephen B. Bandini, Shivani Singh
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Patent number: 8758899Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: September 21, 2011Date of Patent: June 24, 2014Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Publication number: 20120012033Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: September 21, 2011Publication date: January 19, 2012Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Patent number: 8092585Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: October 19, 2010Date of Patent: January 10, 2012Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Publication number: 20110093082Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: October 19, 2010Publication date: April 21, 2011Applicant: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Patent number: 7815963Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: May 5, 2008Date of Patent: October 19, 2010Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen Gawalt
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Patent number: 7569285Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: GrantFiled: June 24, 2002Date of Patent: August 4, 2009Assignee: The Trustees of Princeton UniversityInventors: Jeffrey Schwartz, Michael P. Danahy, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Michael D. Carolus, Ellen S. Gawalt
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Patent number: 7507483Abstract: An implantable device with a metal, metal alloy, metalloid, polymeric or ceramic surface and a phosphonic acid coating layer directly contacting the surface wherein the surface has hydroxyl groups covalently bonded to the acid groups of the coating layer and the phosphonate organic ligands are omega-functionalized.Type: GrantFiled: April 1, 2003Date of Patent: March 24, 2009Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael D. Carolus, Eric L. Hanson, Jean E. Schwarzbauer, Kim S. Midwood, Michael P. Danahy
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Publication number: 20080206443Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osteoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: May 5, 2008Publication date: August 28, 2008Applicant: THE TRUSTEES OF PRINCETON UNIVERSITYInventors: Jeffrey Schwartz, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Ellen S. Gawalt
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Publication number: 20040265571Abstract: The present invention provides a process for providing on the surface of a substrate a chemically bonded, densely-packed, oriented organic acid-based mono-layer, the method comprising: (i) providing on at least a portion of said surface of said substrate a densely-packed, adsorbed oriented mono-layer comprising a plurality of at least one organic acid species wherein each of the organic acid species comprising said adsorbed mono-layer has at least one acid functional group associated with said surface of said substrate; and (ii) bonding to the surface of said substrate said surface-associated acid functional groups.Type: ApplicationFiled: November 4, 2003Publication date: December 30, 2004Applicant: Princeton UniversityInventors: Jeffrey Schwartz, Eric L. Hanson, Michael D. Carolus, Michael P. Danahy, Jean E. Schwarzbauer, Kim S. Midwood
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Publication number: 20040023048Abstract: The present invention provides increased adhesion between the native oxide surface of a material and adhesive material or tissue by providing a phosphorous-based coating layer comprising a plurality of omega-functionalized organo-phosphonate moieties bonded to the native oxide surface of a substrate by a phosphonate bond and a plurality of one or more coating moieties selected from the group consisting of inorganic, organic, or bioactive moieties, each said coating moiety being bonded to the omega-functional group of at least one omega-functionalized organo-phosphonate moiety by means of a member of the group comprising a metal complex and an organic polymer, and when bonded by means of a metal complex, the metal complex further characterized by being derived from a metal alkoxide reagent, and when bonded by means of an organic polymer, the organic polymer further characterized by being derived from an ionic or step-reaction polymerization which incorporates one or more of said omega-functional groups into saType: ApplicationFiled: April 1, 2003Publication date: February 5, 2004Inventors: Jeffrey Schwartz, Michael J. Avaltroni, Michael D. Carolus, Eric L. Hanson, Jean E. Schwarzbauer, Kim S. Midwood, Michael P. Danahy
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Publication number: 20040001959Abstract: The present invention provides a dense-coverage, adherent phosphorous-based coating on the native oxide surface of a material. Disclosed phosphorous-based coatings include phosphate and organo-phosphonate coatings. The present invention also provides further derivatization of the phosphorous-based coatings to yield dense surface coverage of chemically reactive coatings and osetoblast adhesion-promoting and proliferation-promoting coatings on the native oxide surface of a titanium material.Type: ApplicationFiled: June 24, 2002Publication date: January 1, 2004Inventors: Jeffrey Schwartz, Michael P. Danahy, Michael J. Avaltroni, Kim S. Midwood, Jean E. Schwarzbauer, Michael D. Carolus, Ellen S. Gawalt