Patents by Inventor Jean F. Desreux

Jean F. Desreux has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Self-assembling heteropolymetallic chelates as imaging agents and radiopharmaceuticals
    Patent number: 6056939
    Abstract: Metal complexes of new ligands of the formula ##STR1## are useful as agents for medical imaging, particularly MRI, for in vitro or in vivo diagnostic or as radiopharmaceuticals. In these compounds, X--R.sup.1 --Y is a coordinating group able to form a highly stable complex with metal ions. Suitable units are for example derivatives of ortho-phenanthroline or of an hydroxamic acid. R.sup.2 and R.sup.3 are reactive functions such as amines or carboxylic groups. R.sup.4 and R.sup.5 are ligands, for instance diethylenetriaminepentaacetic acid 1,4,7,10-tetraacetic acid (DTPA), 1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid (DOTA) or 1,4,8,11-tetraazacyclotetradecane-N, N', N", N'"-tetraacetic acid (TETA), of a different type than the X--R.sup.1 --Y units and able to strongly encapsulate metal ions with which the X--R.sup.1 --Y moieties form less stable chelates.
    Type: Grant
    Filed: August 28, 1998
    Date of Patent: May 2, 2000
    Inventors: Jean F. Desreux, Vincent Jacques, Valerie Humblet, Martine Hermann, Vinciane Comblin-Tholet, Michael F. Tweedle
  • Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents
    Patent number: 5358704
    Abstract: Novel compounds of the formula ##STR1## and metal chelates of the compounds are useful particularly for MRI of the hepatobiliary system.
    Type: Grant
    Filed: September 30, 1993
    Date of Patent: October 25, 1994
    Assignee: Bristol-Myers Squibb
    Inventors: Jean F. Desreux, Michael F. Tweedle, Peter C. Ratsep, Thomas R. Wagler, Edmund R. Marinelli