Abstract: Systems and methods for data storage and readout using hybrid nucleic acid-polymeric molecules are herein disclosed. A molecular data storage medium is presented comprising a header and a footer, each comprising or consisting of at least one unit of a first chemical species; and a sequence-controlled polymeric chain of a second chemical species located between said header and said footer, said polymeric chain encoding for a desired bitstream-format media.

Abstract: Some embodiments are directed to sequence-defined polyurethanes and methods of making and using same.

Abstract: Some embodiments are directed to sequence-defined polyurethanes and methods of making and using same.

Abstract: Synthesizing poly(alkoxyamine amide)s, which have a monomer chain with at least one thermolabile bond between monomers from an acid monomer of a monohalogenated carboxylic acid X—C(R,R?)—Y—COOH and an amine monomer having a free terminal free-radical nitroxide group >N—O? and a free terminal primary amine —NH2. The synthesis involves two separate and chemically selective chemical reactions. One reacts the —COOH and —NH2 groups to obtain an amide bond —NH—CO—Y—C(R, R?)—, and the other reacts the —Y—C(R, R?)? free-radical with the nitroxide function >N—O? in order to obtain an alkoxyamine bond —Y—C(R, R?)—O—N<. The chemical reactions are performed in alternating fashion with catalysts and a novel halogenated acid monomer X—C(R,R?)—Y—COOH or a novel free-radical amine monomer having a free terminal group >N—O? and a free terminal primary amine —NH2, until a complete copolymer chain is obtained. Also the polymers obtained and the uses thereof.

Abstract: The invention relates to a culture substrate having thermoresponsive microgel particles that have a thermoresponsive polymer and modulator particles fixed to the carrier area of the substrate. The modulator can be a substance that has an adhesion capability with biological cells or a substance that causes cellular reactions that are inducible to binding to surface receptors of biological cells. Methods for preparation and use in culturing cells are given.

Abstract: Synthesizing poly(alkoxyamine amide)s, which have a monomer chain with at least one thermolabile bond between monomers from an acid monomer of a monohalogenated carboxylic acid X—C(R,R?)—Y—COOH and an amine monomer having a free terminal free-radical nitroxide group >N—O? and a free terminal primary amine —NH2. The synthesis involves two separate and chemically selective chemical reactions. One reacts the —COOH and —NH2 groups to obtain an amide bond —NH—CO—Y—C(R, R?)—, and the other reacts the —Y—C(R, R?)? free-radical with the nitroxide function >N—O? in order to obtain an alkoxyamine bond —Y—C(R, R?)—O—N<. The chemical reactions are performed in alternating fashion with catalysts and a novel halogenated acid monomer X—C(R,R?)—Y—COOH or a novel free-radical amine monomer having a free terminal group >N—O? and a free terminal primary amine —NH2, until a complete copolymer chain is obtained. Also the polymers obtained and the uses thereof.

Abstract: A substrate (10), in particular for receiving biological cells (21) comprises a substrate body (1) which has a support area (2) on which there are fixed thermoreactive microgels (3) which comprise particles containing a thermoreactive polymer. Also described are a process for the preparation of the substrate (10) and a method for culturing biological cells (21) on the substrate (10).

Abstract: The present invention relates to a polymerization process for the control of the microstructure of polymers and to novel copolymers. An embodiment of the present invention relates a process of polymerizing first and second monomers in the presence of a complex comprising at least one of the monomers. The presence of the complex modifies the relative reactivity, or cross propagation rate constants, of the monomers in copolymerization reactions. Embodiments of the present invention allow the synthesis of polymers with novel stereochemistry and monomer sequence distribution, for example, but not limited to, copolymers with at least one segment of alternating monomers, a controlled molecular weight and narrow molecular weight distribution, or a segment of high concentration of the first monomer.

Abstract: A polymerization process is provided for the preparation of graft (co)polymers. An embodiment of the polymerization process of the present invention comprises copolymerizing macromonomers with (co)monomers utilizing a macroinitiator to form a graft (co)polymer. A further embodiment of a polymerization process of the present invention comprises (co)polymerizing macromonomers and monomers with a graft copolymer macroinitiator to form a block-graft (co)polymer. Another embodiment of the process of the present invention comprises (co)polymerizing macromonomers and monomers with a compatible macroinitiator. The chemical and structural properties of the product graft (co)polymer may be controlled by use of a compatible macroinitiator and the functional group on the macromonomer which effect the relative rates of incorporation of the macromonomer and the monomer. Graft (co)polymers may be prepared with homogeneous or heterogeneous distribution of grafts.

Abstract: The invention relates to polyalcoxyamines obtained from beta-substituted nitroxides of formula (1) wherein A represents a di- or polyvalent structure, R1 represents a molar mass of more than 15 and is a monovalent radical, and n>2. The inventive compounds can be used as initiators for (co)polymerizations of at least one radically polymerizable monomer.

Abstract: The present invention relates to a polymerization process for the control of the microstructure of polymers and to novel copolymers. An embodiment of the present invention relates a process of polymerizing first and second monomers in the presence of a complex comprising at least one of the monomers. The presence of the complex modifies the relative reactivity, or cross propagation rate constants, of the monomers in copolymerization reactions. Embodiments of the present invention allow the synthesis of polymers with novel stereochemistry and monomer sequence distribution, for example, but not limited to, copolymers with at least one segment of alternating monomers, a controlled molecular weight and narrow molecular weight distribution, or a segment of high concentration of the first monomer.

Abstract: The invention concerns alkoxyamines derived from &bgr;-phosphorous nitroxides corresponding to formula (I). Said compounds can be used as (co)polymerization initiators of at least a monomer polymerizable by radical polymerization.

Abstract: A polymerization process is provided for the preparation of graft (co)polymers. An embodiment of the polymerization process of the present invention comprises copolymerizing macromonomers with (co)monomers utilizing a macroinitiator to form a graft (co)polymer. A further embodiment of a polymerization process of the present invention comprises (co)polymerizing macromonomers and monomers with a graft copolymer macroinitiator to form a block-graft (co)polymer. Another embodiment of the process of the present invention comprises (co)polymerizing macromonomers and monomers with a compatible macroinitiator. The chemical and structural properties of the product graft (co)polymer may be controlled by use of a compatible macroinitiator and the functional group on the macromonomer which effect the relative rates of incorporation of the macromonomer and the monomer. Graft (co)polymers may be prepared with homogeneous or heterogeneous distribution of grafts.