Patents by Inventor Jean-Francis Spindler
Jean-Francis Spindler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 8329955Abstract: Amino compounds are continuously prepared by hydrogenation of nitrile compounds in the presence of a catalyst, and more particularly diamines are prepared by the continuous hydrogenation of dinitrile compounds in the presence of a Raney metal catalyst and in the absence of an alcoholic solvent; the subject process includes extracting a portion of the catalyst present in the reaction medium, the extracted portion of the catalyst is submitted to a regeneration for providing a catalyst having a catalytic activity lower than that of a fresh catalyst but still high and the regenerated catalyst is recycled to the reaction medium together with fresh catalyst according to a predetermined ratio, whereby the consumption of catalyst is reduced per ton of amines produced.Type: GrantFiled: October 2, 2008Date of Patent: December 11, 2012Assignee: Rhodia OperationsInventors: Didier Letourneur, Philippe Leconte, Jean-Francis Spindler, Patrick Lermusiaux, Vincent Boschat
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Publication number: 20100267989Abstract: Amino compounds are continuously prepared by hydrogenation of nitrile compounds in the presence of a catalyst, and more particularly diamines are prepared by the continuous hydrogenation of dinitrile compounds in the presence of a Raney metal catalyst and in the absence of an alcoholic solvent; the subject process includes extracting a portion of the catalyst present in the reaction medium, the extracted portion of the catalyst is submitted to a regeneration for providing a catalyst having a catalytic activity lower than that of a fresh catalyst but still high and the regenerated catalyst is recycled to the reaction medium together with fresh catalyst according to a predetermined ratio, whereby the consumption of catalyst is reduced per ton of amines produced.Type: ApplicationFiled: October 2, 2008Publication date: October 21, 2010Inventors: Didier Letourneur, Philippe Leconte, Jean-Francis Spindler, Patrick Lermusiaux, Vincent Boschat
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Publication number: 20090240061Abstract: The invention relates to a method for forming a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group and a nucleophilic compound, in the absence of a ligand. The aim of the invention is especially to form carbon-nitrogen bonds according to a method for the arylation of nitrogenated organic derivatives. According to the inventive method, a carbon-carbon or carbon-heteroatom bond is formed by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound donating a carbon atom or a heteroatom (HE) that can substitute the leaving group, thus forming a C—C or C—HE bond, in the presence of a copper-based catalyst and a base. Said metal is characterised in that the reaction takes place in the absence of a ligand and in a nitrile-type solvent.Type: ApplicationFiled: July 28, 2004Publication date: September 24, 2009Applicant: Shasun Pharma Solutions, Inc.Inventors: Jean-Francis Spindler, Marc Taillefer, Henri-Jean Cristau, Pascal Philippe Cellier, Armelle Ouali
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Publication number: 20090036718Abstract: The invention relates to processes for aromatic nucleophilic substitution by contacting a substrate of formula (III) Ar-???(III) where Ar is an aromatic group where the nucleus carrying the group ? is electron-poor, either because it contains at least one heteroatom in its ring or because the sum of the Hammett constants, ?p, of its substituents, apart from said ?, is at least 0.2, and ? is a leaving group, with a composition containing at least one ionic compound whose cation is of general formula G: (R10)(R9)N—[C(R8)?C(R6)]?—C(R5)?N+(R1)(R2)??(G) wherein: ? is an integer from 0 to 4, inclusive; R1, R2, R5, R6 and R8, which are identical or different, are a hydrogen or a hydrocarbon group; and R9 and R10, which are identical or different, are a hydrocarbon group; or one or two of the substituents R1, R2, R5, R8, R9, and R10 are connected to other remaining substituent(s) to form one or two or more rings.Type: ApplicationFiled: May 1, 2008Publication date: February 5, 2009Applicant: RHODIA CHIMIEInventors: Rene GREE, Vincent Schanen, Jean-Francis Spindler, Maxime Garayt, Virginie Le Boulaire, Danielle Gree
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Patent number: 7393980Abstract: The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.Type: GrantFiled: May 16, 2002Date of Patent: July 1, 2008Assignee: Rhodia ChimieInventors: Maxime Garayt, Virginie Le Boulaire, Danielle Gree, René Gree, Vincent Schanen, Jean-Francis Spindler
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Patent number: 7202367Abstract: The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.Type: GrantFiled: May 31, 2002Date of Patent: April 10, 2007Assignee: Rhodia ChimieInventors: Pascal Philippe Cellier, Henri-Jean Cristau, Jean-Francis Spindler, Marc Taillefer
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Publication number: 20060149093Abstract: The invention concerns a method for separating a hydroxybenzonitrile-type compound obtained by an amination/dehydration process. More particularly, the invention concerns 2-hydroxybenzonitrile, also called 2-cyanophenol. The inventive method for separating a hydroxybenzonitrile compound from a reaction gas flow comprising it wholly or partly in the form of an ammonium salt is characterized in that it consists in displacing the ammonium ions, through a physical treatment carried out on the reaction gas flow derived from its preparation or from the solid previously recuperated from said flow or according to a chemical treatment carried out on the reaction gas flow, after liquefaction.Type: ApplicationFiled: June 13, 2001Publication date: July 6, 2006Inventors: Jean-Francis Spindler, Roland Jacquot, Michel Alas
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Patent number: 6960665Abstract: The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogent-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one at least bidentate ligand comprising at least two chelating atoms, namely at least one oxygen atom and at least one nitrogen atom.Type: GrantFiled: May 31, 2002Date of Patent: November 1, 2005Assignee: Rhodia ChimieInventors: Pascal Philippe Cellier, Henri-Jean Cristau, Jean-Francis Spindler, Marc Taillefer
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Publication number: 20050065350Abstract: The present invention concerns a process for creating a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound. The invention also concerns the creation of a carbon-nitrogen bond using a process for arylating organic nitrogen-containing derivatives. The process of the invention is a process for creating a carbon-carbon or carbon-heteroatom bond by reacting an unsaturated compound carrying a leaving group with a nucleophilic compound carrying a carbon atom or a heteroatom (HE) that can substitute for the leaving group, creating a C—C or C-HE bond, characterized in that the reaction takes place in the presence of an effective quantity of a catalyst based on a metallic element M selected from group (VIII), (IB) and (IIB) of the periodic table and at least one at least bidentate ligand comprising at least two chelation atoms, namely at least one oxygen atom and at least one nitrogen atom.Type: ApplicationFiled: December 20, 2002Publication date: March 24, 2005Inventors: Marc Taillefer, Henri-Jean Cristau, Passcal Cellier, Jean-Francis Spindler
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Publication number: 20040144947Abstract: The invention relates to a novel method for producing nucleophilic substitutions, particularly of type SNAr and SN2. More specifically, the invention relates to the use as a fluorinating reaction medium of ionic liquid or fused salt comprising at least four carbon atoms. The invention can be used for the synthesis of fluoride derivatives.Type: ApplicationFiled: November 12, 2003Publication date: July 29, 2004Inventors: Maxime Garayt, Virginie Le Boulaire, Danielle Gree, Rene Gree, Vincent Schanen, Jean-Francis Spindler
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Publication number: 20030236413Abstract: The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogen-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one ligand comprising at least one imine function and at least one supplemental nitrogen atom as the chelating atoms.Type: ApplicationFiled: May 31, 2002Publication date: December 25, 2003Inventors: Pascal Philippe Cellier, Henri-Jean Cristau, Jean-Francis Spindler, Marc Taillefer
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Publication number: 20030171593Abstract: The present invention concerns a process for arylating or vinylating or alkynating a nucleophilic compound. More particularly, the invention concerns arylating nitrogent-containing organic derivatives. The arylating or vinylating or alkynating process of the invention consists of reacting a nucleophilic compound with a compound carrying a leaving group and is characterized in that the reaction is carried out in the presence of an effective quantity of a catalyst based on a metallic element M selected from groups (VIII), (Ib) and (IIb) of the periodic table and at least one at least bidentate ligand comprising at least two chelating atoms, namely at least one oxygen atom and at least one nitrogen atom.Type: ApplicationFiled: May 31, 2002Publication date: September 11, 2003Inventors: Pascal Philippe Cellier, Henri-Jean Cristau, Jean-Francis Spindler, Marc Taillefer
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Publication number: 20030149272Abstract: The invention concerns a method for preparing a polyaromatic compound comprising at least a chain formation of two aromatic cycles. The method for preparing a polycyclic aromatic compound comprising at least a chain formation of two aromatic cycles is characterised in that it consists in reacting an aromatic compound bearing a leaving group and an alkaline organometallic compound, in the presence of an efficient amount of a nickel catalyst, said element being optionally complexed with at least a co-ordination agent or ligand.Type: ApplicationFiled: November 4, 2002Publication date: August 7, 2003Inventors: Henri-Jean Cristau, Corinne Bouchitte, Marc Taillefer, Jean-Francis Spindler, Thierry Schlama
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Patent number: 6576782Abstract: The invention concerns a halogenation in position meta of a phenol fuction. Said halogenation comprises a step which consists in halogenating an aromatic derivative of a medium or advantageously strong acid, the aromatic radical being a phenyl substituted in ortho and in para by functions attracting electrons by inductive effect. The invention is applicable to organic synthesis.Type: GrantFiled: October 4, 2001Date of Patent: June 10, 2003Assignee: Rhodia ChimieInventors: Jean-Roger Desmurs, Geneviève Padilla, Jean-Francis Spindler
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Publication number: 20010051749Abstract: The invention concerns a method for transforming an aminophenol, characterized in that it consists in a step whereby said aminophenol aniline function is in the form of an anilide function and said phenol is dissolved in a hydophobic and weakly polar solvent in the presence of water, an alkaline hydroxide, a phase transfer catalyst and a halide or an alkyl pseudo-halide. The invention is applicable to organic synthesis.Type: ApplicationFiled: March 15, 2001Publication date: December 13, 2001Inventors: Jean-Roger Desmurs, Jean-Francis Spindler, Harivelo Gerard Rajoharison
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Patent number: 5777166Abstract: The present invention relates to the field of the catalytic reduction of nitriles to amines by use of Raney catalysts doped with one or a number of additional metal elements chosen from the elements of group IVb of the periodic classification.More precisely, it relates to a process for the hydrogenation of nitriles to amines, characterized in that it essentially consists:in selecting a liquid reaction medium which dissolves the nitrile substrate to be hydrogenated,in using at least one inorganic alkali metal or alkaline-earth metal hydroxide base,and in adopting a catalyst whose doping element/Ni ratio by weight is between 0.05 and 10%.More specific application to the hydrogenation of dinitriles to diamines or to aminonitriles.Type: GrantFiled: November 25, 1996Date of Patent: July 7, 1998Assignee: Rhone-Poulenc ChimieInventors: Georges Cordier, Pierre Fouilloux, Nathalie Laurain, Jean-Francis Spindler