Abstract: The present invention relates to intermediates and processes useful for preparing 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof. The present invention further relates to 1-ethyl-N-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide and salts thereof when prepared by such processes and to associated pharmaceutical compositions and uses for the treatment and prevention of medical disorders and diseases, most especially by NLRP3 inhibition.

Abstract: The present invention relates to the following compounds wherein the integers are as defined in the description, and where the compounds may be useful as medicaments, for instance for use in the treatment of tuberculosis.

Abstract: An assembly includes a nacelle panel of an aircraft engine, the nacelle panel including an outer skin, an inner skin and a central layer interposed between the outer and inner skins. The central layer has a housing, the outer skin has an opening which opens into the housing, and a linking member extends in the opening and in the housing, the linking member to be connected to an actuator.

Abstract: Machine learning, artificial intelligence, and other computer-implemented methods are used to identify various semantically important chunks in documents, automatically label them with appropriate datatypes and semantic roles, and use this enhanced information to assist authors and to support downstream processes. Chunk locations, datatypes, and semantic roles can often be automatically determined from what is here called “context”, to wit, the combination of their formatting, structure, and content; those of adjacent or nearby content; overall patterns of occurrence in a document, and similarities of all these things across documents (mainly but not exclusively among documents in the same document set).

Abstract: A diagnostic ultrasound system has a 2D array transducer which is operated with 1×N patches, patches which are only a single element wide. The “N” length of the patches extends in the elevation direction of a scanned 2D image plane, with the single element width extending in the lateral (azimuth) direction. Focusing is done along each patch in the elevation direction by a microbeamformer, and focusing in the lateral (azimuth) direction is done by the system beamformer. The minimal width of each patch in the azimuth direction enables the production of images highly resolved in the azimuthal plane of a 2D image, including the reception of highly resolved multilines for high frame rate imaging.

Abstract: A thermally expandable composition includes at least one polymer P, at least one chemical blowing agent CBA, at least one physical blowing agent PBA composed of expandable microspheres, and at least one filler F. A damping element includes a first layer composed of an expansion material and a second layer composed of an acoustic damping material. The damping element is suitable for providing vibration and/or noise damped systems.

Abstract: A sealing element, in particular for sealing a frame element with respect to a building component, having a sandwich structure, including: a metallic primary layer which is creped at least in certain regions to form an elongation reserve of the sealing element; a secondary layer; and a bitumen-including filling layer which is arranged between the primary layer and the secondary layer.

Abstract: A manufacturing process to a bis-mesylate salt 1b of the pan-RAF inhibitor 4-amino-n-(1-((3-chloro-2-fluorophenyl)amino)-6-methylisoquinolin-5-yl)thieno[3,2-d]pyrimidine-7-carboxamide. The process features a number of efficient key reactions, including a robust and scalable Pd-catalyzed carbonylation reaction to generate thienopyrimidine 2 and a highly chemoselective PtN/C-catalyzed nitro group reduction to access penultimate intermediate 7. The final amide coupling of 7 and 2 was accomplished by a mild and safe protocol employing N,N,N?,N?-tetramethylchloroformamidinium hexafluorophosphate (TCFH) as the coupling reagent, to produce a 1:1 adduct of the freebase and THF. The adduct afforded compound 1b with excellent yield, purity, and form stability on a multikilogram production scale after reaction with MsOH and recrystallization. The methods are able to produce a compound having upwards of 95% purity.

Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.

Abstract: Apparatus for determining a property of products, in particular plant or animal products, the apparatus comprising: a conveyor configured for conveying products one-by-one along a transport path in a transport direction; a light source configured for illuminating a first illumination area of the transport path, wherein the first illumination area extends substantially across the transverse width of the transport path; and a sensor structure configured for receiving light from a sensing area of the transport path, wherein the sensing area extends substantially across the transverse width of the transport path, wherein the sensing area is adjacent to the first illumination area.

Abstract: The present invention relates to a process according to Scheme 1 for the preparation of microbiocidal 5-trifluoromethyl-1,2,4-oxadiazole derivatives of formula (I) suitable for use, e.g., as active ingredients, which have microbiocidal activity, in particular, fungicidal activity.

Abstract: In one embodiment, an interactivity agent provides display data from a plurality of devices to a touch screen display via a network for simultaneous presentation on the touch screen display. The interactivity agent receives touch information regarding a touch action performed via the touch screen display with respect to the display data from a particular one of the plurality of devices. The interactivity agent translates the received touch information from the touch screen display into translated touch information for the particular device. The interactivity agent sends, to a particular device via the network, the translated touch information. The translated touch information causes the particular device to replicate the touch action on a display of the particular device.

Abstract: A method for manufacturing a weldable steel component having a chemical composition including, by weight: 0.40%?C?0.45%; 0.75%?Si?1.50%; 0.3%?Mn?3%; 0%?Ni?5%; 1.11%?Cr?4%; 0%?Cu?1%; 0.410%?Mo?1.5%; 0.410%?Mo+W/2?1.5%; 0.038%?Nb?0.3%; 0.0005%?B?0.010%; 0.006%?N?0.025%; Al?0.9%; Si+Al?2.0%, optionally at least one element selected among V, Nb, Ta, S and Ca, in contents less than 0.3%, and among Ti and Zr in contents not more than 0.5%, the rest being iron and impurities resulting from the preparation, the aluminium, boron, titanium and nitrogen contents, expressed in thousandths of %, of said composition further satisfying the following relationship: B??×K+0.5, (1) with K=Min (I*; J*), I*=Max (0; 1), and J*=Max (0; J), I=Min(N; N?0.29(Ti?5)), J=Min(N; 0.5(N?0.52 Al+?{square root over ((N?0.52 Al)2+283)})), and whereof the structure is bainitic, martensitic or martensitic/bainitic and additionally comprises 3 to 20% of residual austenite.

Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.

Abstract: In some implementations, a system may generate information that identifies a passphrase to be used as a biometric input. The system may receive a voice input of a user speaking the passphrase. The system may generate one or more cryptographic keys based on the voice input. The system may generate a digital identifier based on the one or more cryptographic keys. The system may generate one or more biometric templates for the user. The system may encrypt the one or more biometric templates using the one or more cryptographic keys and to generate one or more encrypted biometric templates. The system may store in a secure storage associated with the user, at least one of the digital identifier, a public key of the one or more cryptographic keys, a phone number associated with the user, or the one or more encrypted biometric templates. Numerous other aspects are provided.

Abstract: The invention concerns steel building components whereof the chemical composition comprises, by weight: 0.40 %=C=0.50%, 0.50%=Si=1.50%, 0%=Mn=3%, 0%=Ni=5%, 0%=Cr=4%, 0%=Cu=1%, 0%=Mo+W/2=1.5%, 0.0005%=B=0.010%, N=0.025 %, Al?0.9%, Si+Al=2.0%, optionally at least one element selected among V, Nb, Ta, S and Ca, in contents less than 0.3%, and among Ti and Zr in contents not more than 0.5%, the rest being iron and impurities resulting from the preparation, the aluminium, boron, titanium and nitrogen contents, expressed in thousandths of %, of said composition further satisfying the following relationship: B=?×K+0.5, (1) with K=Min (1*; J*), I*=Max (0;1) and J*=Max(0;J), I=Min(N; N?0.29(Ti?5)), J=Min {N; 0.5 (N?0.52 Al+v(N?0.52 Al)2+283)}, and whereof the structure is bainitic, martensitic or martensitic/bainitic and additionally comprises 3 to 20% of residual austenite. The invention also concerns a method for making said components.

Abstract: Compounds of formula (I) as defined herein, to processes for preparing them, to pesticidal, in particular insecticidal, acaricidal, molluscicidal and nematicidal compositions comprising them and to methods of using them to combat and control pests such as insect, acarine, mollusc and nematode pests.

Abstract: A sealing element, in particular for sealing a frame element with respect to a building component, having a sandwich structure, including: a metallic primary layer which is creped at least in certain regions to form an elongation reserve of the sealing element; a secondary layer; and a bitumen-including filling layer which is arranged between the primary layer and the secondary layer.

Abstract: Compounds of formula (I), wherein the substituents are as defined in claim 1, and the agrochemically acceptable salts, stereoisomers, enantiomers, tautomers and N-oxides of those compounds, can be used as insecticides and can be prepared in a manner known per se.

Abstract: Compounds of the formula (I), in which the substituents are as defined in claim 1, are suitable for use as nematicides.