Abstract: A single leg support for sitting on by a user has a seat member adjustably connected to a post member, with the post member connected to a base member which contacts a ground surface. In typical use, the support axis of the support is between about five and twenty-five degrees relative to the vertical such that the user remains in equilibrium with most of his/her weight supported by his two legs at about five degrees from the vertical with the knees slightly bent. Thus, the support carries only a small portion of the user's weight for increased comfort. The support is adapted to be fitted into a bicycle. Additionally, the support may be used with a heavy base member having a flexible joint allowing rotating movement of the support while a user is seated thereon.

Abstract: A single leg support for sitting on by a user has a seat member adjustably connected to a post member, with the post member connected to a base member which contacts a ground surface. In typical use, the support axis of the support is between about five and twenty-five degrees relative to the vertical such that the user remains in equilibrium with most of his/her weight supported by his two legs at about five degrees from the vertical with the knees slightly bent. Thus, the support carries only a small portion of the user's weight for increased comfort. The support is adapted to be fitted into a bicycle. Additionally, the support may be used with a heavy base member having a flexible joint allowing rotating movement of the support while a user is seated thereon.

Abstract: A spacer maintains a structure in a spaced relationship relative to a mould inner surface surrounding structure and having a mould inner opening impermeably covered by a stretchable sheath. Stretchable sheath engages structure when a retaining force for retaining structure in spaced relationship is applied during introduction of a settable mixture into space to form a product therein. When retaining force is withdrawn, sheath is smoothly aligned with mould inner surface and smoothly bounds space therewith for forming product. By impermeably covering mould inner opening, sheath further prevents flow of settable mixture outside of space there through.

Abstract: The invention concerns the use of Grb14 and homologous adapting proteins, as tool for screening molecules designed for the treatment of diseases involving insulin. The invention also concerns a method for detecting molecules capable of modulating the tyrosine kinase activity of the insulin receptor.