Patents by Inventor Jean Jacques

Jean Jacques has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • (6R)- and (6S)-diastereoisomers of an ammonium salts of N.sup.5 -methyl-5,6,7,8-tetrahydrofolic acid
    Patent number: 5382581
    Abstract: There are described ammonium salts of N.sup.5 -methyl-5,6,7,8-tetrahydrofolic acid as well as processes for their preparation. These ammonium salts may be separated into the single (6R) and (6S)-diastereoisomers. The separated diastereoisomers may be transformed into the corresponding alkali metal or alkaline earth metal salts.
    Type: Grant
    Filed: November 13, 1992
    Date of Patent: January 17, 1995
    Assignee: Sapec S.A. fine chemicals
    Inventors: Fabrizio Marazza, Jean Jacques
  • Separation technique for a mixture of (6RS)-diastereoisomers of an ammonium salt of N.sup.5 -methyl-5,6,7,8-tetrahydrofolic acid into single (6R) and (6S)-diastereoisomers
    Patent number: 5194611
    Abstract: There are described ammonium salts of N.sup.5 -methyl-5,6,7,8-tetrahydrofolic acid as well as processes for their preparation. These ammonium salts may be separated into the single (6R) and (6S)-diastereoisomers. The separated diastereoisomers may be transformed into the corresponding alkali metal or alkaline earth metal salts.
    Type: Grant
    Filed: April 11, 1991
    Date of Patent: March 16, 1993
    Assignee: Sapec S.A. fine chemicals
    Inventors: Fabrizio Marazza, Jean Jacques
  • Antiandrogenic compounds and methods
    Patent number: 5158981
    Abstract: A antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.
    Type: Grant
    Filed: March 30, 1990
    Date of Patent: October 27, 1992
    Assignee: Roussel Uclaf
    Inventors: Marie-Madeleine Bouton, Jean Jacques, Andre Pierdet
  • Process for preparing certain decahydro-7H-3-ol-7-ones
    Patent number: 4927975
    Abstract: Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.
    Type: Grant
    Filed: July 25, 1988
    Date of Patent: May 22, 1990
    Assignee: Roussel Uclaf
    Inventors: Marie-Madeleine Bouton, Jean Jacques, Andre Pierdet
  • Benzindenolones as antiandrogenic agents
    Patent number: 4849454
    Abstract: Novel antiandrogenic compositions comprising an anti-androgenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.
    Type: Grant
    Filed: April 24, 1986
    Date of Patent: July 18, 1989
    Assignee: Roussel Uclaf
    Inventors: Marie-Madeleine Bouton, Jean Jacques, Andre Pierdet
  • Antiandrogenic compositions containing indene-7-ones
    Patent number: 4607054
    Abstract: Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.- or .beta.
    Type: Grant
    Filed: October 19, 1983
    Date of Patent: August 19, 1986
    Assignee: Roussel Uclaf
    Inventors: Marie-Madeleine Bouton, Jean Jacques, Andre Pierdet
  • Certain decahydro-7H-benz(e)-inden-7-ones, compositions containing same and method of use
    Patent number: 4466971
    Abstract: Novel antiandrogenic compositions comprising an antiandrogenically effective amount of at least one compound of the formula ##STR1## wherein R is alkyl of 1 to 4 carbon atoms, R.sub.1 is alkyl of 1 to 2 carbon atoms, R.sub.2 is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms optionally interrupted with a heteroatom, alkenyl and alkynyl of 2 to 8 carbon atoms optionally interrupted with a heteroatom, formyl and acyl of an organic carboxylic acid of 2 to 18 carbon atoms, R.sub.3 is selected from the group consisting of hydrogen, alkyl of 1 to 4 carbon atoms and alkenyl and alkynyl of 2 to 4 carbon atoms, R.sub.4 is selected from the group consisting of hydrogen and alkyl of 1 to 4 carbon atoms, the dotted lines indicate optional presence of a double bond between the 4(5) and 5a(6) carbons and the wavy line indicates that R.sub.4 may be in the .alpha.-or .beta.
    Type: Grant
    Filed: February 19, 1982
    Date of Patent: August 21, 1984
    Assignee: Roussel Uclaf
    Inventors: Marie-Madeleine Bouton, Jean Jacques, Andre Pierdet