Patents by Inventor Jean-Jacques Bourguignon
Jean-Jacques Bourguignon has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20230076057Abstract: The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and multiple sclerosis.Type: ApplicationFiled: December 18, 2020Publication date: March 9, 2023Inventors: JEAN-JACQUES BOURGUIGNON, MARTINE SCHMITT, JACQUES BRICARD, TANGUI MAURICE
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Publication number: 20230049619Abstract: The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and multiple sclerosis.Type: ApplicationFiled: December 18, 2020Publication date: February 16, 2023Inventors: JEAN-JACQUES BOURGUIGNON, MARTINE SCHMITT, JACQUES BRICARD, TANGUI MAURICE
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Publication number: 20210221784Abstract: The invention relates to compounds, pyridine derivatives, and pharmaceutical 10 compositions containing same for use in the treatment of pain. It also relates to specific compounds, compositions comprising the same and uses thereof, in particular in the treatment of pain.Type: ApplicationFiled: February 5, 2019Publication date: July 22, 2021Applicants: Université de Strasbourg, Centre National de la Recherche ScientifiqueInventors: Martine SCHMITT, Jacques BRICARD, Frédéric SIMONIN, Jean-Jacques BOURGUIGNON, Frédéric BIHEL, Khadija ELHABAZI
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Patent number: 9663493Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: June 29, 2016Date of Patent: May 30, 2017Assignees: Northwestern University, Universite De Strasbourg, Centre National De La Recherche Scientifique (CNRS)Inventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 9527819Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: December 3, 2014Date of Patent: December 27, 2016Assignees: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20160326139Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: June 29, 2016Publication date: November 10, 2016Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
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Publication number: 20150175555Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: December 3, 2014Publication date: June 25, 2015Applicants: NORTHWESTERN UNIVERSITY, UNIVERSITE DE STRASBOURG, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS)Inventors: D. Martin WATTERSON, Linda VAN ELDIK, Jacques HAIECH, Marcel HIBERT, Jean-Jacques BOURGUIGNON, Anastasia VELENTZA, Wenhui HU, Magdalena ZASADZKI
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Patent number: 8933076Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.Type: GrantFiled: June 8, 2012Date of Patent: January 13, 2015Assignees: Centre National de la Recherche Scientifique (CNRS), Northwestern University, Universite de StrasbourgInventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 8367672Abstract: The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: November 2, 2005Date of Patent: February 5, 2013Assignees: Universite de Strasbourg, Northwestern University, Centre National de la Recherche Scientifique (CNRS)Inventors: D. Martin Watterson, Linda J. Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Publication number: 20120245125Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of making and using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for, research, drug screening, and therapeutic applications.Type: ApplicationFiled: June 8, 2012Publication date: September 27, 2012Applicants: Northwestern UniversityInventors: D. Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdalena Zasadzki
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Patent number: 8088774Abstract: A novel class of pyridazine compositions and related methods of use.Type: GrantFiled: July 7, 2010Date of Patent: January 3, 2012Assignees: Northwestern University, Universite de Strasbourg, Centre National de la Recherche Scientifique, A Scientific Research CentreInventors: Daniel Martin Watterson, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon
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Patent number: 8063047Abstract: The invention relates to novel chemical compounds of Formula I compositions and methods of using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: GrantFiled: May 12, 2008Date of Patent: November 22, 2011Assignees: Centre National de la Recherche Scientifique (CNRS), Northwestern University, Universite de StrasbourgInventors: Martin Watterson, Linda Van El Dik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Veleniza, Wenhui Hu, Magdaena Zasadzki
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Patent number: 7888357Abstract: A novel class of pyridazine compositions and related methods of use.Type: GrantFiled: October 26, 2005Date of Patent: February 15, 2011Assignees: Northwestern University, Universite de Strasbourg, Centre National de la Recherche ScientifiqueInventors: Daniel Martin Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Haiech, Jean-Jacques Bourguignon, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert
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Publication number: 20100317665Abstract: A novel class of pyridazine compositions and related methods of use.Type: ApplicationFiled: July 7, 2010Publication date: December 16, 2010Inventors: D.M. Watterson, Anastasia Velentza, Magdalena Zasadzki, Jacques Halech, Jean-Jacques Bourguignon, Anu R. Sawkar, Thomas J. Lukas, Salida Mirzoeva, Linda J. Van Eldik, Marcel Hibert
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Publication number: 20090270495Abstract: We disclose substances and a process of developing such substances as potent and selective inhibitors of isoforms of phosphodiesterases of types 1 to 5 (PDE1, PDE2, PDE3, PDE4, PDE5) based on two flavonoids: dioclein, floranol and natural or synthetic analogs thereof. They may be associated with cyclodextrins in inclusion complexes or using a biodegradable or non-biodegradable polymer, such as PLGA, PLA, PGA or mixtures thereof in controlled release devices. Their respective pharmaceutical compositions as well as pharmaceutical and pharmacologically acceptable excipients may be used for the study and treatment of cardiovascular diseases and associated products.Type: ApplicationFiled: March 30, 2006Publication date: October 29, 2009Inventors: Virginia Soares Lemos, Stayner De Franca Cortes, Bruno Almeida Resende, Roberta Lins Goncalves, Ruben Dario Sinisterra Milan, Martine Schmitt, Claire Lugnier, Jean-Jacques Bourguignon
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Publication number: 20090221613Abstract: The invention relates to the use of adenine-derived compounds substituted in the 2- and 9-positions and, optionally, in the N(6)-position of the adenine, for the manufacture of a medicament for use in the treatment of systemic lupus erythematosus (SLE). The compounds can also be used in combination with a second compound used in the treatment of SLE.Type: ApplicationFiled: March 6, 2007Publication date: September 3, 2009Applicant: Centre National de la Recherche Scientifique (CNRS).Inventors: Claire Renee Jeanne Lugnier, Sylviane Paule Ghislaine Muller, Fanny Slyvie Michele Monneaux, Jean-Jacques Bourguignon
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Publication number: 20090029985Abstract: The invention relates to novel chemical compounds, compositions and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: May 12, 2008Publication date: January 29, 2009Inventors: Martin Watterson, Linda Van El Dik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Valeniza, Wenhui Hu, Magdena Zasadzki
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Publication number: 20080318899Abstract: The invention relates to novel chemical compounds and methods of making and using the same. In particular, the invention provides pyridazine compounds and/or related heterocyclic derivatives, compositions comprising the same, and methods of using pyridazine compounds and/or related heterocyclic derivatives and compositions comprising the same, for modulation of cellular pathways (e.g., signal transduction pathways), for treatment or prevention of inflammatory diseases (e.g., Alzheimer's disease), for research, drug screening, and therapeutic applications.Type: ApplicationFiled: November 2, 2005Publication date: December 25, 2008Inventors: Martin Watterson, Linda Van Eldik, Jacques Haiech, Marcel Hibert, Jean-Jacques Bourguignon, Anastasia Velentza, Wenhui Hu, Magdelena Zasadzki
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Patent number: 7250410Abstract: The invention concerns novel benzodiazepine derivatives and their uses in the field of therapeutics particularly for treating pathologies involving the activity of a cyclic nucleotide phosphodiesterase. It also concerns methods for preparing them and novel synthesis intermediates.Type: GrantFiled: June 7, 2002Date of Patent: July 31, 2007Assignee: Via Pharmaceuticals, Inc.Inventors: Jean-Jacques Bourguignon, Yan Lagouge, Claire Lugnier, Eveline Klotz, Jean-Paul Macher, Pierre Raboisson, Dominique Schultz
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Publication number: 20060194259Abstract: A method for isolating an allosteric effector of a receptor, by determining the variation of the dissociation kinetics of the complex formed between the receptor and one of its ligands in the presence of the allosteric effector, as compared to the kinetics dissociation, in the absence of the effector, and/or the amplitude of the linkage formed between the receptor and the ligand in the presence of the allosteric effector, as compared to the amplitude in the absence of the effector. The receptor and ligand are being involved in at least one biological response, and the allosteric effector is capable of modulating at least one of the responses. The receptor is marked by at least one fluorescent protein, and the ligand by a molecule capable of absorbing light, or by a fluorescent substance.Type: ApplicationFiled: June 16, 2003Publication date: August 31, 2006Inventors: Jean-Luc Galzi, Marcel Hibert, Jean-Jacques Bourguignon, Emalina Maillet