Patents by Inventor Jean-Jacques Mention

Jean-Jacques Mention has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Boosting human dendritic cell development, homeostasis and function in xenografted immunodeficient mice
    Patent number: 9439404
    Abstract: The present invention relates to a transgenic animal model system based on the development of transgenic mice bearing components of the human immune system. Specifically, the invention relates to a Flk2 deficient Rag?/??c?/? transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further provides methods for increasing the numbers of functionally competent human dendritic cells and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential immune adjuvants and for developing novel therapeutics.
    Type: Grant
    Filed: February 18, 2014
    Date of Patent: September 13, 2016
    Assignees: INSERM (Institut National de la Santé et de la Recherche Médicale), INSTITUT PASTEUR
    Inventors: James Di Santo, Jean-Jacques Mention
  • BOOSTING HUMAN DENDRITIC CELL DEVELOPMENT, HOMEOSTASIS AND FUNCTION IN XENOGRAFTED IMMUNODEFICIENT MICE
    Publication number: 20140165220
    Abstract: The present invention relates to a transgenic animal model system based on the development of transgenic mice bearing components of the human immune system. Specifically, the invention relates to a Flk2 deficient Rag?/??c?/? transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further provides methods for increasing the numbers of functionally competent human dendritic cells and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential immune adjuvants and for developing novel therapeutics.
    Type: Application
    Filed: February 18, 2014
    Publication date: June 12, 2014
    Applicants: INSTITUT PASTEUR, INSERM (Institut National de la Santé et de la Recherche)
    Inventors: James Di SANTO, Jean-Jacques MENTION
  • BOOSTING HUMAN DENDRITIC CELL DEVELOPMENT, HOMEOSTASIS AND FUNCTION IN XENOGRAFTED IMMUNODEFICIENT MICE
    Publication number: 20120094312
    Abstract: The present invention relates to a transgenic animal mode system based on the development of transgenic mice bearing components of the human immune system. Specifically, the Invention relates to a Flk2 deficient Rag “?c” transgenic mouse and the engraftment of said mouse with human hematopoietic stem cells. The present invention further presides methods for increasing the numbers of functionally competent human dendritic cells is and the hematopoietic targets cells that they interact with in said transgenic mouse through the administration of Flk2L. The transgenic animal model system of the invention may be used for testing human vaccine candidates, for screening potential Immune adjuvants and for developing novel therapeutics.
    Type: Application
    Filed: April 2, 2010
    Publication date: April 19, 2012
    Applicants: INSTITUT PASTEUR, INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA REC HERCHE)
    Inventors: James Di Santo, Jean-Jacques Mention