Abstract: The invention concerns compositions and methods for preparing recombinant adenoviruses. The resulting adenoviruses can be used for transferring and/or expressing genes in cells, in vitro, ex vivo or in vivo, or also in functional genomics. More particularly, the invention concerns in particular efficient methods for producing adenovirus banks and the use of said banks in functional genomics. The invention also concerns plasmids used for constructing said adenoviruses.

Abstract: The invention concerns compositions and methods for preparing recombinant adenoviruses. The resulting adenoviruses can be used for transferring and/or expressing genes in cells, in vitro, ex vivo or in vivo, or also in functional genomics. More particularly, the invention concerns in particular efficient methods for producing adenovirus banks and the use of said banks in functional genomics. The invention also concerns plasmids used for constructing said adenoviruses.

Abstract: A tool for mounting a belt in a groove of a pulley of an automotive vehicle wherein the pulley has a rim and a flat lateral surface on each side of its groove. The tool includes a main body having an internal flat body surface and an external flat body surface; a flap provided on an edge of the main body and bent substantially at a right angle relative to the internal flat body surface and in the direction thereof. The tool also has a belt guiding area having substantially an arcuate shape and projecting substantially normally from the external flat body surface. The tool is useful for mounting a power transmission striated belt that includes an elastomeric matrix and a lengthwise supporting structure consisting of polyamide 4.6 twisted strands.

Abstract: A method for regenerating an amine extractant used for recovery of metals involves contacting a liquid organic phase containing an amine complexed with one or more metals with an aqueous solution substantially free of chloride ions to strip the one or more metals from the organic phase. The stripped organic phase is then contacted with a solution of hydrochloric acid to regenerate the amine extractant which can then be recycled in a production process.

Abstract: A tool for mounting a belt in a groove of a pulley of an automotive vehicle wherein the pulley has a rim and a flat lateral surface on each side of its groove. The tool includes a main body having an internal flat body surface and an external flat body surface; a flap provided on an edge of the main body and bent substantially at a right angle relative to the internal flat body surface and in the direction thereof. The tool also has a belt guiding area having substantially an arcuate shape and projecting substantially normally from the external flat body surface. The tool is useful for mounting a power transmission striated belt that includes an elastomeric matrix and a lengthwise supporting structure consisting of polyamide 4.6 twisted strands.

Abstract: The power transmission striated belt includes an elastomeric matrix (21) and a lengthwise supporting structure consisting of polyamide 4.6 twisted strands (20). The supporting structure (21) is selected so that the stress-elongation diagram of the belt exhibits an average slope ranging from 12 to 20 daN/% of elongation per width centimeter. The twisted strands are wound with an almost null nominal tension, and the curing operation and the cooling operation after curing are carried out without any belt tensioning.

Abstract: The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.

Abstract: A method for regenerating an amine extractant used for recovery of metals involves contacting a liquid organic phase containing an amine complexed with one or more metals with an aqueous solution substantially free of chloride ions to strip the one or more metals from the organic phase. The stripped organic phase is then contacted with a solution of hydrochloric acid to regenerate the amine extractant which can then be recycled in a production process.

Abstract: The present invention relates to a power transmission striated belt including an elastomeric matrix (21) and a lengthwise supporting structure consisting of polyamide 4.6 twisted strands (20). The supporting structure (21) is selected so that the stress-elongation diagram of the belt exhibits an average slope ranging from 12 to 20 daN/% of elongation per width centimeter. The twisted strands are wound with an almost null nominal tension, and the curing operation and the cooling operation after curing are carried out without any belt tensioning.

Abstract: The invention concerns a recombinant DNA vector characterized in that it is capable of directing the expression an/or transcription of a selected nucleotide sequence in the cells of the central nervous system and in that it comprises (i) at least part of the genome of an adenovirus, including the regions required for that adenovirus to penetrate into the cells normally infectable by that adenovirus and (ii) being inserted into said part of genome of an adenovirus under the control of a promoter, either present or also inserted into said genome part and operative in said cells. This recombinant vector finds particular use in the treatment of diseases of the central nervous system, also in gene therapy.

Abstract: The invention concerns a method for reducing recombination phenomena among nucleic acids. It also concerns the use of said method for producing defective viruses not contaminated by replication particles. The invention further concerns novel viral constructs.

Abstract: The present invention relates to a power transmission striated belt including an elastomeric matrix (21) and a lengthwise supporting structure consisting of polyamide 4.6 twisted strands (20). The supporting structure (21) is selected so that the stress-elongation diagram of the belt exhibits an average slope ranging from 12 to 20 daN/% of elongation per width centimeter. The twisted strands are wound with an almost null nominal tension, and the curing operation and the cooling operation after curing are carried out without any belt tensioning.

Abstract: Recombinant viruses comprising a heterologous DNA sequence coding for a protein having glutamate decarboxylase (GAD) activity, preparation thereof, and therapeutic use thereof, in particular for treating and/or preventing degenerative neurological diseases.

Abstract: The present invention pertains to the use of compounds affecting the activity of transcription factors for the preparation of a pharmaceutical composition for the treatment of neurodegenerative diseases.

Abstract: A power transmission striated belt including an elastomeric matrix (21) and a lengthwise supporting structure consisting of polyamide 4.6 twisted strands (20). The supporting structure (21) is selected so that the stress-elongation diagram of the belt exhibits an average slope ranging from 12 to 20 daN/% of elongation per width centimeter. The twisted strands are wound with an almost null nominal tension, and the curing operation and the cooling operation after curing are carried out without any belt tensioning.

Abstract: This is a method of regenerating dithiophosphorus acids from disulfides containing sulfur--sulfur bonds, formed by oxidation of dithiophosphorus acids, such as sulfur--sulfur bonding of dithiophosphoric, dithiophosphonic and dithiophosphinic acids, in a solvent extraction organic phase in which the dithiophosphorus acid is dissolved in a diluent. This process reacts metal directly with the organic solution containing the disulfide to produce a metal loaded complex form of the regenerated dithiophosphorus extractant in the organic solution. This metal complex forms by direct reaction of the metal with the disulfides without requiring the presence or the formation of nascent or gaseous hydrogen. The organic solution containing the regenerated dithiophosphorus extractant can be either directly recycled into a solvent extraction circuit or recycled after the loaded metal is stripped.