Abstract: The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and multiple sclerosis.

Abstract: Novel plumbing products, including faucets, are fabricated, e.g., using metallic 3-dimensional or other 3-D printing techniques, to have complex geometries, such as multiple channels that may diverge and re-converge near the spout. The geometries of the various channels can resemble interwoven net-like patterns that define various shapes between the channels. The plumbing fixtures may be formed from one or more of stainless steels, INCONEL, brass, bronze, polycarbonate, PVC, acrylics, rigid polyolefins, PET, carbon fiber, AES, or other plumbing fitting suitable corrosion resistant materials. In some embodiments, the handles of an exemplary faucet can include the same or a similar multiple channel configuration as the spout, providing an advantageously, aesthetically pleasing faucet system. In exemplary embodiments, faucet spouts and their handles are formed so as to couple to standard faucet underbodies, standard valve platforms, or standard threaded hose/waterway connections.

Abstract: A mechanism including a magnetic gear including a first wheel, a second wheel and a third wheel. The first wheel is provided with permanent magnetic poles which are arranged so as to form the magnetised teeth of a first magnetic toothing. The second wheel and the third wheel are provided with teeth made of a soft ferromagnetic material respectively defining a second magnetic toothing and a third magnetic toothing, each with a number of teeth that is greater than that of the first magnetic toothing and having a magnetic coupling with this first magnetic toothing. The second magnetic toothing is directly coupled with the first magnetic toothing and with the third magnetic toothing thanks to the magnetic fluxes provided by the magnetised teeth of the first toothing and the teeth of the second magnetic toothing are magnetically separated from one another.

Abstract: A mechanism (1) including a magnetic gear (2) including a first wheel (6B) and a second wheel (6C) provided with a first magnetic toothing (10) and a second magnetic toothing (12) respectively. The first and second magnetic toothings are respectively formed by first and second teeth made of a soft ferromagnetic material; and the magnetic gear (2) further includes a third wheel (6A) arranged between the first and second wheels (6B, 6C) and provided with a third magnetic toothing (8) formed by permanent magnetic poles, in particular by bipolar magnets. In general, the first wheel is a drive wheel, whereas the second wheel is driven into order to carry out a function or transmit a torque. The third intermediate wheel is preferably mounted such that it can rotate freely.

Abstract: A shower head can include: a shower face removably mounted to the shower head, the shower face including a plurality of channels configured to deliver a spray, each channel including openings on opposite sides of the shower face; and a user-activated mechanism configured to remove the shower face from the shower head to allow customization of the spray from the shower head.

Abstract: A bearing for an arbor or staff of a rotary wheel set of a timepiece movement, the bearing including a bearing block provided with a housing and an endstone arranged inside the housing, the endstone having a main body provided with a cavity configured to receive a pivot of the arbor of the rotary wheel set, the pivot having the shape of a first cone having a first solid angle, the apex of the first cone being rounded with a predefined first radius of curvature in a range from 0.2 ?m to 50 ?m, the cavity having a second cone shape with a second solid angle, greater than the first solid angle, so that the pivot can rotate in the cavity, the apex of the second cone being rounded and having a predefined second radius of curvature. The second radius of curvature is smaller than the first radius of curvature.

Abstract: A system for the axial retention of a holding ring for a bearing for guiding in rotation a rotary shaft of a turbomachine is disclosed. The system includes an annular bearing support and a bearing holding ring that is borne by the annular bearing support. The bearing holder ring includes an upstream ring configured to be brought into contact with the bearing support and a downstream ring that is elastically deformable. The bearing support has a first axial retention element, and the bearing holding ring has a second axial retention element. The first and second axial retention elements are configured to cooperate with one another to axially retain the bearing holding ring in the event of damage to the downstream ring.

Abstract: The present invention relates to the field of medicine. More specifically, the present invention relates to compounds that are sigma-1 receptor agonists and their use for the treatment of central nervous system disorders, including cognitive or neurodegenerative disorders, such as Alzheimer's disease, Parkinson's disease, Huntington's disease, Amyotrophic lateral sclerosis, and multiple sclerosis.

Abstract: A ball joint is disclosed containing a body of a joint, where there is inserted a pin having a longitudinal axis and including a first threaded end and a second spherical end which is rotatably arranged within a seat of the body and able to co-operate with a first spherical-cap-shaped element or shell inserted within a seat having a corresponding shape of a second spherical-cap-shaped element or shell cooperating with a covering element so as to close the spherical end of the pin within the body. The second spherical end of the pin and the first and second shells including pairs of recesses and ridges in the contact areas are suitable for reciprocally compenetrating, with the pairs of recesses and ridges being arranged at 90° to each other to allow the rotation of the pin along all axes in the space (X, Y, Z).

Abstract: A method for operating an autonomous feed robot at a feed table in a livestock area, in which one or more stationary cameras are disposed to monitor the feed table, includes obtaining one or more images captured using the one or more stationary cameras and indicative of a distribution of feed on the feed table and controlling the operation of the autonomous feed robot based on the distribution of feed indicated by the one or more images. The disclosure also relates to control circuitry, an autonomous feed robot, and a computer program for performing the method.

Abstract: Disclosed is a method for preventing, controlling or treating a fungal infection on a plant. The method includes applying to such plant organ a non-fungicidal amount or a potentiating amount of a composition including a potentiating agent of a plant defense molecule, in association with a phytopharmaceutical vehicle.

Abstract: A simulation testing architecture can be applied to an aircraft monitoring system for an aircraft that includes complex algorithms (such as machine learning algorithms) for sensing objects around the aircraft and controlling the aircraft to avoid such objects. A reference scenario is selected from a plurality of stored scenarios based on a desired set of aircraft safety standards. A stochastic process is applied to generate a large number of conditional variations within a simulated environment, varying weather, objects in the airspace, points of failure, and the like to provide a representative sample of possible aircraft missions and encounters within the selected reference scenario. Synthetic environmental inputs are fed into the aircraft monitoring system software, and the resultant actions of the software are logged. These logs can be used to generate metrics on an encounter-level basis, a scenario-level basis, or across a population of scenarios.

Abstract: Light emitting structures and methods of fabrication are described. In an embodiment, LED coupons are transferred to a carrier substrate and then patterned to LED mesa structures. Patterning may be performed on heterogeneous groups of LED coupons with a common mask set. The LED mesa structure are then transferred in bulk to a display substrate. In an embodiment, a light emitting structure includes an arrangement of LEDs with different thickness, and corresponding bottom contacts with different thicknesses bonded to a display substrate.

Abstract: A component for detecting electromagnetic radiation includes a detection structure and a supply circuit for the detection structure. The detection structure includes a transistor associated with an absorbent element for detecting the rise in temperature of the absorbent element when electromagnetic radiation is absorbed. The supply circuit is configured to supply the detection structure in operation such that a channel zone of the structure has, at the location of one of its first and the second faces, a layer having carriers of a second type of conductivity opposite to a first type of conductivity of a source zone and of a drain zone of the transistor, the layer being referred to as blocking layer.

Abstract: Disclosed are a composition containing a transition metal, as well as a method of treatment of bacterial, or of fungal diseases using such composition. The composition functions as novel bactericides and antifungal agents. The transition metal may be in either soluble or insoluble form.

Abstract: Cumene hydroperoxide oligomer according to Formula (I): in which OLIGOMER is a homo- or copolymer chain, which is substituted n times by the group which is in brackets; Q is absent or is a divalent aromatic C6-C14 hydrocarbon radical or an aliphatic, linear or branched C1-C14 hydrocarbon radical, which can be interrupted by one or more S and/or O atoms and/or —O—CO—NR1— and which can be substituted by one or more substituents; X, Y independently of each other in each case are absent, —O—, —COO—; —CONR3— or —O—CO—NR4—, wherein X is absent if Q is absent, and wherein the substitution on the aromatic compound is effected in position 2, 3 or 4 relative to the cumene hydroperoxide group; and n is a value from 1 to 50.

Abstract: The refrigerant compressor includes a compressor casing (2); an oil sump (13) arranged in the compressor casing (2); and an oil level sensor arrangement (14) configured to detect an oil level in the oil sump (13), the oil level sensor arrangement (14) including a tubular element (16) secured to the compressor casing (2) and a floating element (17) surrounding the tubular element (16) and being movably mounted with respect to the tubular element (16). The compressor casing (2) includes a passage opening (24) and dimensions of the tubular element (16), the floating element (17) and the passage opening (24) are defined to allow an insertion and a removal of the tubular element (16) and the floating element (17) into and out of the compressor casing (2) through the passage opening (24).

Abstract: A process for fabricating a detecting device includes producing a getter pad based on amorphous carbon resting on a mineral sacrificial layer that covers a thermal detector and producing a thin encapsulating layer that rests on the mineral sacrificial layer and that covers an upper face and sidewalls of the getter pad. The mineral sacrificial layer is removed via a first chemical etch, and a protective segment of the getter pad is removed via a second chemical etch.

Abstract: A horological movement (6) including: a plate (7); a mechanical resonator (8) including an oscillating balance (11) rotatably mounted relative to the plate (7), and a spiral spring (22) coupled to the balance (11); an electromagnetic regulator (29) coupled to the mechanical resonator (8) to regulate the frequency of the oscillations of the balance (11), and including at least one permanent magnet (30) fixedly mounted relative to the plate (7), at least one coil (31), a quartz or silicon resonator (32) and an electronic circuit (33) connected to the resonator (32) and to the coil (31), all mounted on the balance (11) while being completely included in an inner cavity (18) delimited by the latter.

Abstract: The present invention relates to halogenated salicylanilides, or pharmaceutically acceptable salts or esters thereof, for use in the treatment of an infection in a subject caused by Clostridium bacteria, particularly a C. difficile infection. The halogenated salicylanilides are expected to be useful in the treatment of C. difficile associated diseases including C. difficile associated diarrhoea and C. difficile associated colitis.