Patents by Inventor Jean Lautrou

Jean Lautrou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 4877600
    Abstract: Lysine salt of the complex of gadolinium (III) of 1,4,7,10-tetraazacyclododecane-N,N',N",N'"-tetraacetic acid. Said salt has a low toxicity and may be used as diagnostic agent in magnetic resonance imaging.
    Type: Grant
    Filed: December 7, 1987
    Date of Patent: October 31, 1989
    Assignee: Guerbet S.A.
    Inventors: Bruno Bonnemain, Jean Lautrou, Dominique Meyer
  • Patent number: 4474747
    Abstract: X-ray contrast media, for which the human body has a greater tolerance than that of contrast media comprising solely iodobenzene compounds, and an opacity of the same order of magnitude as the latter contrast media, comprise mixtures of benzene compounds nuclearly substituted with a plurality of iodine atoms and of benzene compounds nuclearly substituted with a plurality of bromine atoms, the bromobenzene compounds having the mole ratio from 1/2 to 2/1 to the iodobenzene compounds in the mixture.
    Type: Grant
    Filed: August 18, 1982
    Date of Patent: October 2, 1984
    Assignee: Guerbet S.A.
    Inventors: Ioana Dimo, Bruno Bonnemain, Jean C. Hardouin, Jean Lautrou
  • Patent number: 4225577
    Abstract: This invention relates to compounds of the formula (I): ##STR1## in which: n is an integer from 1 to 5 inclusive,R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkanoyl group,R.sub.2 represents a hydrogen atom, a C.sub.1-4 alkanoyl group, or a C.sub.1-4 alkyl group,R.sub.3 represents a hydrogen atom, a group of the formula ##STR2## or of the formula --CONHR.sub.6, in which: R.sub.4 represents a hydrogen atom or a C.sub.1-4 alkanoyl group,R.sub.5 represents a hydrogen atom or a C.sub.1-4 alkanoyl group, or a C.sub.1-4 alkyl group,R.sub.6 represents a hydrogen atom or a C.sub.1-4 alkyl group,R.sub.7 represents a hydrogen atom or a methyl group, and their C.sub.1-4 alkyl esters and their salts with pharmaceutically acceptable bases.Said compounds are useful as X-ray contrast media.
    Type: Grant
    Filed: May 29, 1979
    Date of Patent: September 30, 1980
    Assignee: Guerbet S.A.
    Inventors: Guy Tilly, M. Jean-Charles Hardouin, Jean Lautrou
  • Patent number: 4107286
    Abstract: This invention relates to compounds of the formula: ##STR1## in which: R.sub.1 represents a hydrogen atom or a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical,R.sub.2 represents a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical,A represents a group of the formula: ##STR2## in which: R.sub.3 represents a hydrogen atom, a group of the formula ##STR3## in which R.sub.5 and R.sub.6 represent each a hydrogen atom or a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical, or a group of the formula ##STR4## in which R.sub.7 represents a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical and R.sub.8 represents a hydrogen atom, a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical,a is 0 or 1 and n is an integer from 1 to 5 inclusive,R.sub.4 represents a hydrogen atom or a C.sub.1-4 alkyl radical or a C.sub.1-4 hydroxyalkyl radical, their methyl and ethyl esters and their salts with pharmaceutically acceptable bases.Said compounds are useful as X-ray contrast media.
    Type: Grant
    Filed: March 29, 1977
    Date of Patent: August 15, 1978
    Assignee: Guerbet S.A.
    Inventors: Guy Tilly, Michel Jean-Charles Hardouin, Jean Lautrou
  • Patent number: 4094966
    Abstract: The present invention provides new iodobenzene derivatives which have at least two benzene nuclei and one carboxylic group.These derivatives possess a low toxicity and may be used as X-ray contrast media.
    Type: Grant
    Filed: December 7, 1976
    Date of Patent: June 13, 1978
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
  • Patent number: 4065553
    Abstract: The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group.These derivatives possess a low toxicity and may be used as X-ray contrast media.
    Type: Grant
    Filed: December 3, 1976
    Date of Patent: December 27, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
  • Patent number: 4065554
    Abstract: The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group.These derivatives possess a low toxicity and may be used as X-ray contrast media.
    Type: Grant
    Filed: December 6, 1976
    Date of Patent: December 27, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
  • Patent number: 4062934
    Abstract: This invention relates to compounds having the following general formula: ##STR1## in which n is an integer from 0 to 4; R.sub.1 and R.sub.2 represent independently from each other a radical of the formula --CONHR.sub.5 in which R.sub.5 is an alkyl radical having 1-4 carbon atoms or a hydroxyalkyl radical having 1-4 carbon atoms or a radical of the formula ##STR2## in which R.sub.6 and R.sub.7 are alkyl radicals having 1-4 carbon atoms; and R.sub.3 and R.sub.4, independently from each other, represent a hydrogen atom or an alkyl radical having 1-4 carbon atoms.Said compounds are useful as X-ray contrast media, particularly for myelography.
    Type: Grant
    Filed: May 25, 1976
    Date of Patent: December 13, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean-Charles Hardouin, Jean Lautrou
  • Patent number: 4014986
    Abstract: The present invention provides new iodo benzene derivatives which have at least two benzene nuclei and one carboxylic group.These derivatives possess a low toxicity and may be used as X-ray contrast media.
    Type: Grant
    Filed: May 20, 1975
    Date of Patent: March 29, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou
  • Patent number: 4005188
    Abstract: This invention relates to compounds of the formula: ##STR1## in which: R.sub.1 represents a hydrogen atom or a radical of the formula ##STR2## in which R.sub.4 and R.sub.5 represent, independently of each other, a hydrogen atom or a lower alkyl radical,R.sub.2 represents a hydrogen atom or a lower alkanoyl radical,R.sub.3 represents a hydrogen atom, a lower alkyl radical or a lower alkanoyl radical,n is 3 or 4,And their lower alkyl esters and their salts with pharmaceutically acceptable bases.Said compounds are useful as X-ray contrast media.
    Type: Grant
    Filed: May 20, 1975
    Date of Patent: January 25, 1977
    Assignee: Laboratoires Andre Guerbet
    Inventors: Guy Tilly, Michel Jean Charles Hardouin, Jean Lautrou