Patents by Inventor Jean Leboul

Jean Leboul has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Publication number: 20020051828
    Abstract: The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament.
    Type: Application
    Filed: December 12, 2000
    Publication date: May 2, 2002
    Applicant: RHONE-POULENC RORER S.A. and INSTITUT MALGACHE DE RECHERCHES APPLIQUEES
    Inventors: Albert Rakoto Ratsimamanga, Suzanne Rakoto Ratsimamanga, Philippe Rasoanaivo, Jean Leboul, Jean Provost, Daniel Reisdorf
  • Patent number: 6300375
    Abstract: The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament.
    Type: Grant
    Filed: December 12, 2000
    Date of Patent: October 9, 2001
    Assignees: Rhone-Poulenc Rorer SA, Institut Malgache DeRecherches Appliquees
    Inventors: Albert Rakoto Ratsimamanga, Suzanne Rakoto Ratsimamanga, Philippe Rasoanaivo, Jean Leboul, Jean Provost, Daniel Reisdorf
  • Patent number: 6194412
    Abstract: The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament.
    Type: Grant
    Filed: June 9, 1999
    Date of Patent: February 27, 2001
    Assignees: Rhone-Poulenc Rorer S.A., Institut Malgache de Recherches
    Inventors: Albert Rakoto Ratsimamanga, Suzanne Rakoto Ratsimamanga, Philippe Rasoanaivo, Jean Leboul, Jean Provost, Daniel Reisdorf
  • Patent number: 5972342
    Abstract: The present invention relates to mixtures which can be isolated from grains of Eugenis Jambolana Lamarck, the preparation of such mixtures, the medicaments containing said mixtures or constituents of said mixtures, and the use of these mixtures and constituents for the preparation of a medicament.
    Type: Grant
    Filed: August 6, 1998
    Date of Patent: October 26, 1999
    Assignees: Rhone-Poulenc Rorer S.A., Institute Malgache De Recherches Appliquees
    Inventors: Albert Rakoto Ratsimamanga, Suzanne Rakoto Ratsimamanga, Philippe Rasoanaivo, Jean Leboul, Jean Provost, Daniel Reisdorf
  • Patent number: 5849724
    Abstract: A Chrysosporium strain No. CBS 123.95, mutants and derivatives thereof, and a method for preparing non-peptide compounds using said strain, are disclosed. Novel compounds of general formula (I), pharmaceutical compositions containing same, and the use of said compounds in anticancer treatments, are also disclosed.
    Type: Grant
    Filed: August 8, 1997
    Date of Patent: December 15, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean Leboul, Didier Van der Pyl, Jean-Jacques Debernard
  • Patent number: 5840682
    Abstract: The invention is directed to a compound of formula ##STR1## in which R represents a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH.sub.2 --COOH radical, R.sub.1 represents a hydrogen atom, an adamantylacetyl, adamantylcarbonyl, norbornylacetyl, norbornylphenoxycarbonyl, benzoyl, nicotinoyl, 4-phenylbenzoyl, 4-tert-butylbenzoyl or 2-pyrrolidinecarbonyl radical or a protective group for an amine functional group, R.sub.2 represents an Arg or Lys residue, R.sub.3 represents an Arg or Lys residue, R.sub.4 represents a Pro residue, m, n and p, which are the identical or different, represent a number equal to 0 or 1, R.sub.5 and R.sub.6 are identical and represent a hydroxyl or methoxy radical and R.sub.7 represents a hydrogen, chlorine, bromine or iodine atom or a nitro radical, or the compound wherein one or a number of peptide bonds between two amino acid residues are replaced by --CH.sub.2 --NH bonds or the peptide bond between the R.sub.2 and R.sub.3 amino acid residues is replaced by a CH.dbd.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: November 24, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Francois-Frederic Clerc, Marie-Christine Dubroeucq, Gerard Helynck, Jean Leboul, Jean-Paul Martin
  • Patent number: 5747303
    Abstract: The invention is directed to a novel compound of formula ##STR1## in which R is a hydroxyl, alkyloxy, phenylalkyloxy or --NH--CH.sub.2 --COOH radical, R' and R" are identical and are each a hydroxy or methoxy radical and R'" represents a hydrogen, bromine, chlorine or iodine atom or a nitro radical. The invention is also directed to the salts of said compounds and their use.
    Type: Grant
    Filed: November 19, 1996
    Date of Patent: May 5, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean-Jacques Debernard, Catherine Dubertret, Gerard Helynck, Jean Leboul, Jean-Paul Martin
  • Patent number: 5716994
    Abstract: (3-hydroxy-4-methoxybenzyl)-7-methylene-1-vinyl-2,3,3a,4,7,7a-hexahydroinde n-4-one of formula (I): ##STR1## and 3-(3-hydroxy-4-methoxybenzyl)-4-hydroxy-7-methyl-1-vinylindan of formula (II): ##STR2## as well as their stereoisomeric forms are disclosed. Also disclosed are a process for producing these compounds from the plant Ottelia alismoides and pharmaceutical compositions containing them. The novel compounds of formulas (I) and (II) have remarkable antitumor and antileukaemic properties.
    Type: Grant
    Filed: December 19, 1996
    Date of Patent: February 10, 1998
    Assignee: Rhone-Poulenc Rorer S.A.
    Inventors: Jean Leboul, Jean Provost
  • Patent number: 4324579
    Abstract: Amidoximes of the formula ##STR1## are disclosed. R represents a hydrogen atom on a lower alkyl (C.sub.1 -C.sub.4) or phenyl; R.sub.1 represents lower alkyl or a metal atom and Ar represents substituted or unsubstituted phenyl or a five-membered substituted or unsubstituted aromatic heterocyclic group where the hetero atom is selected from the group O, S and N. The compounds have phytohormonal activity at low dosages in plants and herbicidal activity at higher levels.
    Type: Grant
    Filed: January 29, 1980
    Date of Patent: April 13, 1982
    Assignee: Philargo
    Inventors: Daniel Farge, Jean Leboul, Yves Le Goff, Gilbert Poiget
  • Patent number: 4216006
    Abstract: Amidoximes of the formula ##STR1## are disclosed. R represents a hydrogen atom or a hydrogen, lower alkyl (C.sub.1 -C.sub.4) or phenyl; R.sub.1 represents lower alkyl or a metal atom and Ar represents substituted or unsubstituted phenyl or a five-membered substituted or unsubstituted aromatic heterocyclic group where the hetero atom is selected from the group O, S and N. The compounds have phytohormonal activity at low dosages in plants and herbicidal activity at higher levels.
    Type: Grant
    Filed: May 17, 1978
    Date of Patent: August 5, 1980
    Assignee: Philagro
    Inventors: Daniel Farge, Jean Leboul, Yves Le Goff, Gilbert Poiget
  • Patent number: 4188203
    Abstract: 1--Amidoxime derivatives. The amidoximes correspond to the formula: ##STR1## in which: R represents a hydrogen atom or an alkyl radical containing from 1 to 4 carbon atoms and A represents a cyano group or a radical of the general formula: ##STR2## in which R.sub.1 and R.sub.2, which are identical or different, each represent a hydrogen atom, an alkyl radical containing from 1 to 4 carbon atoms, an optionally substituted phenyl radical or an amino radical which is itself optionally substituted. These compounds can be used in agriculture as phytohormones and herbicides.
    Type: Grant
    Filed: July 27, 1978
    Date of Patent: February 12, 1980
    Assignee: Philagro
    Inventors: Daniel Farge, Jean Leboul, Yves Le Goff, Gilbert Poiget
  • Patent number: 4154598
    Abstract: Herbicidal and/or phyto-hormonal compositions containing 1,2,4-oxadiazin-5-one of the formula ##STR1## WHERE R represents H, alkyl or phenyl and Ar represents substituted phenyl or a 5 membered aromatic heterocyclic radical with O, S or N as the hetero-atom and optionally substituted are described.
    Type: Grant
    Filed: February 2, 1978
    Date of Patent: May 15, 1979
    Assignee: Philagro
    Inventors: Daniel Farge, Jean Leboul, Yves Le Goff, Gilbert Poiget
  • Patent number: 4127609
    Abstract: Cyclohexanediol derivatives of the general formula: ##STR1## wherein R.sub.1 and R.sub.2, which are identical, each represent a N.sub.3 or NH.sub.2 group, and the acid addition salts of the derivative containing two NH.sub.2 groups.These compounds are useful as intermediate products for the preparation, for example, of synthetic antibiotics.
    Type: Grant
    Filed: January 22, 1976
    Date of Patent: November 28, 1978
    Assignee: Labaz
    Inventors: Andre Cier, Stephan Gero, Alain Olesker, Jean Leboul
  • Patent number: 4116974
    Abstract: Amidoximes of the formula ##STR1## are disclosed. R represents a hydrogen atom or a hydrogen, lower alkyl (C.sub.1 - C.sub.4) or phenyl; R.sub.1 represents lower alkyl or a metal atom and Ar represents substituted or unsubstituted phenyl or a five-membered substituted or unsubstituted aromatic heterocyclic group where the hetero atom is selected from the group O, S and N. The compounds have phytohormonal activity at low dosages in plants and herbicidal activity at higher levels.
    Type: Grant
    Filed: September 10, 1976
    Date of Patent: September 26, 1978
    Assignee: Philagro
    Inventors: Daniel Farge, Jean Leboul, Yves Le Goff, Gilbert Poiget
  • Patent number: 3952027
    Abstract: Cyclohexanediol derivatives of the general formula: ##SPC1##Wherein R.sub.1 and R.sub.2, which are identical, each represent a N.sub.3 or NH.sub.2 group, and the acid addition salts of the derivative containing two NH.sub.2 groups.These compounds are useful as intermediate products for the preparation, for example, of synthetic antibiotics.
    Type: Grant
    Filed: January 31, 1975
    Date of Patent: April 20, 1976
    Assignee: Labaz
    Inventors: Andre Cier, Stephan Gero, Alain Olesker, Jean Leboul