Patents by Inventor Jean-Louis Brayer
Jean-Louis Brayer has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Patent number: 9527798Abstract: Cyclopropylboronic compounds, the preparation process thereof and the use thereof.Type: GrantFiled: December 12, 2013Date of Patent: December 27, 2016Assignee: DIVERCHIMInventors: Peter Oosting, Emmanuel Thomas, Rukiye Pamuk, Benoit Folleas, Jean-Louis Brayer, Benoit De Carne Carnavalet, Christophe Meyer, Janine Cossy
-
Publication number: 20150329566Abstract: Cyclopropylboronic compounds, the preparation process thereof and the use thereof.Type: ApplicationFiled: December 12, 2013Publication date: November 19, 2015Inventors: Peter OOSTING, Emmanuel THOMAS, Rukiye PAMUK, Benoit FOLLEAS, Jean-Louis BRAYER, Benoit DE CARNE CARNAVALET, Christophe MEYER, Janine COSSY
-
Publication number: 20150004110Abstract: The 1-aryl-2-aryloxyethane compounds of Formula 1 in which n and m are zero or equal to 1, provided that n+m=1, R1 and R2 in particular representing hydrogen atoms, R3 and R4 in particular representing hydrogen atoms, halogen atoms, hydroxy or alkoxy groups, and R5 in particular representing hydrogen atoms, hydroxy, alkyl, alkoxy, amino or nitro groups, in cosmetic compositions intended for anti-ageing and/or depigmenting and/or anti-inflammatory and/or wound-healing care.Type: ApplicationFiled: December 18, 2012Publication date: January 1, 2015Applicant: DIVERCHIMInventors: Natacha Frison, Benoit Folleas, Jean-Louis Brayer, Florence Wafflart
-
Publication number: 20140249105Abstract: Compounds, ceramide analogues, having a cyclic structure derived from cyclopropane, cyclobutane or cyclopentane, the ring bearing two chains consisting of an amide function. Each amide function is attached to the ring by the nitrogen atom of the function and carries a hydrocarbon chain derived from a fatty acid. The amide functions can be cis or trans relative to one another. Processes for the preparation of these novel compounds as well as pharmaceutical and/or cosmetic compositions containing them.Type: ApplicationFiled: July 25, 2011Publication date: September 4, 2014Applicant: DiverchimInventors: Jean-Louis Brayer, Natacha Frison, Benoit Folleas
-
Publication number: 20140012005Abstract: The present invention relates to a process for preparing chiral amino acids with excellent enantiomeric excesses.Type: ApplicationFiled: December 22, 2011Publication date: January 9, 2014Applicant: DiverchimInventors: Sylvain Darses, Nicolas Lefevre, Benoit Folleas, Jean-Louis Brayer
-
Patent number: 8420610Abstract: The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R?1, -A-R?1 group, R?1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3 R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC —(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R?2—O—R6 group, wherein R?2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C 1-C 16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocopheType: GrantFiled: December 14, 2006Date of Patent: April 16, 2013Assignee: Pierre Fabre Dermo-CosmetiqueInventors: Pascal Bordat, Roger Tarroux, Jean-Hilaire Saurat, Olivier Sorg, Jean-Louis Brayer, Natacha Frison
-
Patent number: 7928254Abstract: The invention concerns a method for preparing a compound of formula (I), wherein: R3 and R1 represent in particular H and n is greater than 4, said preparation method including performing a Wittig-Horner reaction with a phosphonate on a lactol, so as to obtain a hydroxyester and, optionally a saponification reaction of said hydroxyester.Type: GrantFiled: October 10, 2006Date of Patent: April 19, 2011Assignee: Pierre Fabre Dermo-CosmetiqueInventors: Natacha Frison, Benoit Folleas, Jean-Louis Brayer
-
Publication number: 20100240754Abstract: The present invention relates to drugs consisting of unsaturated fatty amino-acid derivatives of the general formula (I), and to their pharmaceutically acceptable acid addition salts, in which: X is oxygen or NH, Rn are independently hydrogen or a (C1-C6)alkyl optionally substituted by halogen; R1 is hydrogen, fluorine, chlorine or bromine, or a CF3 or CHF2 or a (C1-C6)alkyl, (C1-C6)alkenyl or (C1-C6)alkynyl, optionally substituted by one or more halogen atoms; R is hydrogen or a (C1-C6)alkyl or (C3-C6)cycloalkyl optionally substituted by one or more halogen atoms; Ra and Rb are independently hydrogen (C1-C6)alkyl or (C1-C6)acyl, and Ra and Rb a hydrocarbonated cycle containing 4 to 6 carbon atoms; and n is an integer between 2 and 14.Type: ApplicationFiled: January 16, 2008Publication date: September 23, 2010Applicant: Pierre Fabre Demo-CosmetiqueInventors: Roger Tarroux, Marie Charveron, Sylvie Daunes-Marion, Natacha Frison, Benôit Folleas, Jean-Louis Brayer
-
Publication number: 20100168045Abstract: The invention concerns novel polyunsaturated compounds of formula (I) wherein: R1 represents a R?1, -A-R?1 group, R?1 being selected from —COOH, —COOR3, —CONH2, —CONHR3, —CONR3, R4, —CHO, —CH2OH, —CH2OR5, and A represents a C2-C16 alkylene, alkenylene or alkynylene; R2 represents: an optionally substituted aryl group or an optionally substituted heteroaryl group; a sugar residue or, a fatty acid residue optionally branched and/or substituted preferably at the chain terminus and particularly by hydroxy, acetoxy radical or by an optionally protected amino radical; a —OC—(CH2)n CO-tocopheryl (alpha, beta or gamma or delta) group, with 2 $m(F) n $m(F) 10; a —R?2—O—R6 group, wherein R?2 is an optionally substituted arylene group or an optionally substituted heteroarylene group, and R6 represents a hydrogen atom, a straight or branched optionally substituted C1-C16 alkyl, a straight or branched optionally substituted C2-C16 alkenyl, or a straight or branched C2-C16 alkynyl group, an optionally substituted tocopheryType: ApplicationFiled: December 14, 2006Publication date: July 1, 2010Applicant: Pierre Fabre Dermo-CosmetiqueInventors: Pascal Bordat, Roger Tarroux, Jean-Hilaire Saurat, Olivier Sorg, Jean-Louis Brayer, Natacha Frison
-
Publication number: 20080281114Abstract: The invention concerns a method for preparing a compound of formula (I), wherein: R3 and R1 represent in particular H and n is greater than 4, said preparation method including performing a Wittig-Horner reaction with a phosphonate on a lactol, so as to obtain a hydroxyester and, optionally a saponification reaction of said hydroxyester.Type: ApplicationFiled: October 10, 2006Publication date: November 13, 2008Applicant: Pierre Fabre Dermo-CosmetiqueInventors: Natacha Frison, Benoit Folleas, Jean-Louis Brayer
-
Publication number: 20040204596Abstract: A method of preparing unsaturated hydroxy fatty acids and esters thereof corresponding to general formula (Id): 1Type: ApplicationFiled: March 12, 2004Publication date: October 14, 2004Applicant: Pierre PotierInventors: Pierre Potier, Francoise Picot, Jean-Louis Brayer
-
Patent number: 5744635Abstract: A method for prerparing compounds of formula (I), wherein R is an optionally substituted alkenyl or alkynyl radical having up to 8 carbon atoms, or an optionally substituted mono- or polycyclic aryl or heteroaryl radical, and R.sub.1 and R.sub.2 are an alkyl radical having up to 4 carbon atoms. According to the method, a compound of the formula (II), wherein X is a halogen atom, is exposed to an organometallic compound of the formula (III): RZ, wherein R has the same meaning as before and Z is a metal or metal derivative. Alternatively, a compound of formula (II'), wherein Z' is a metal or metal derivative, is exposed to a compound of the formula (III'): RX', wherein X' is a nucleophilic reaction leaving group.Type: GrantFiled: October 3, 1995Date of Patent: April 28, 1998Assignee: Roussel UclafInventors: Jean-Louis Brayer, David Michael Hodgson, Ian Christopher Richards, Jason Witherington
-
Patent number: 5508414Abstract: A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenyl, phenoxy, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the group consisting of hydrogen, chlorine, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms and the exocyclic double bonds independently have (E) or (Z) geometry having fungicidal activity and a process for their preparation.Type: GrantFiled: November 18, 1994Date of Patent: April 16, 1996Assignee: Roussel UCLAFInventors: Jean-Louis Brayer, Jean-Pierre Demoute, Gilles Mourioux
-
Patent number: 5451696Abstract: A compound of the formula ##STR1##Type: GrantFiled: September 30, 1994Date of Patent: September 19, 1995Assignee: Roussel-UCLAFInventors: Marc Benoit, Sylvain Laugraud, Jean-Louis Brayer
-
Patent number: 5420340Abstract: A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenyl, phenoxy, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the group consisting of hydrogen, chlorine, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms and the exocyclic double bonds independently have (E) or (Z) geometry having fungicidal activity and a process for their preparation.Type: GrantFiled: January 12, 1994Date of Patent: May 30, 1995Assignee: Roussel UclafInventors: Jean-Louis Brayer, Jean-Pierre Demoute, Gilles Mourioux
-
Patent number: 5380883Abstract: A compound of the formula ##STR1##Type: GrantFiled: April 12, 1993Date of Patent: January 10, 1995Assignee: Roussel-UclafInventors: Marc Benoit, Sylvain Laugraud, Jean-Louis Brayer
-
Patent number: 5310746Abstract: All possible stereoisomer forms and mixtures of a compound of the formula ##STR1## wherein X is a halogen, R.sub.2 and R.sub.3 are individually selected from the group consisting of alkyl and cycloalkyl of up to 8 carbon atoms optionally substituted with at least one halogen, R.sub.1 is selected from the group consisting of alkyl, alkenyl, alkynyl and cycloalkyl of up to 12 carbon atoms optionally substituted with at least one halogen, aryl and heteroaryl of 5 to 6 ring members optionally substituted with at least one member of the group consisting of halogen, alkyl, alkenyl, alkynyl and cycloalkyl of up to 8 carbon atoms optionally substituted with at least one member of the group consisting of --NO.sub.2, --NH.sub.2, --CN, --OR', --SR", --SOR", --SO.sub.2 R", --NR"'.sub.2, --Ar, OAr.sub.1 and SAr.sub.2, R', R" and R"' are individually selected from the group consisting of alkyl, alkenyl, alkynyl and cycloalkyl of up to 12 carbon atoms optionally substituted by at least one halogen, Ar, Ar.sub.1 and Ar.sub.Type: GrantFiled: November 24, 1992Date of Patent: May 10, 1994Assignee: Roussel UclafInventors: Jean-Louis Brayer, Jean-Pierre Demoute, Yannick Le Stanc, Nicole Reinier
-
Patent number: 5304653Abstract: A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenyl, phenoxy, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the group consisting of hydrogen, chlorine, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms and the exocyclic double bonds independently have (E) or (Z) geometry having fungicidal activity and a process for their preparation.Type: GrantFiled: October 6, 1992Date of Patent: April 19, 1994Assignee: Roussel-UclafInventors: Jean-Louis Brayer, Jean-Pierre Demoute, Gilles Mourioux
-
Patent number: 5210093Abstract: A compound of the formula ##STR1## wherein Ar is phenyl optionally substituted with at least one member of the group consisting of halogen, methylenedioxy, phenyl, phenoxy, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, Z is selected from the group consisting of hydrogen, chlorine, --CF.sub.3 and alkyl, alkoxy and alkylthio of 1 to 6 carbon atoms, R.sub.1 and R.sub.2 are individually alkyl of 1 to 6 carbon atoms and the exocyclic double bonds independently have (E) or (Z) geometry having fungicidal activity and a process for their preparation.Type: GrantFiled: March 16, 1992Date of Patent: May 11, 1993Assignee: Roussel UclafInventors: Jean-Louis Brayer, Jean-Pierre Demoute, Gilles Mourioux
-
Patent number: 5198571Abstract: A region-specific monofunctionalization of a phenolic hydroxy onto a polyphenol for the preparation of a compound of the formula ##STR1## wherein R is selected from the group consisting of hydrogen, alkyl of 1 to 8 carbon atoms, alkenyl and alkynyl of 2 to 8 carbon atoms, --CN, formyl, carboxy, alkoxy carbonyl of up to 9 carbon atoms, aralkoxy carbonyl or up to 12 carbon atoms and halogen and R' is a hydroxy protective group comprising reacting a polyphenol of the formula ##STR2## wherein R has the above definition with a base to form the corresponding dianion, reacting the latter with a trialkyl borate of the formulaB(OAlk).sub.3wherein Alk is alkyl of 1 to 6 carbon atoms to form a compound of the formula ##STR3## reacting the latter with a reagent capable of introducing a hydroxy protective group and reacting the latter with a hydrolysis agent for the oxygen-boron bond to obtain the corresponding compound of Formula I.Type: GrantFiled: December 16, 1991Date of Patent: March 30, 1993Assignee: Roussel UclafInventors: Jean-Louis Brayer, Daniel Calvo, Francois Ottello