Patents by Inventor Jean-Louis Maurel

Jean-Louis Maurel has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Derivatives of aryl-{4-halogeno-4-[aminomethyl]-piperidin-1-yl}-methanone, their method of preparation and their use as medicinal products
    Patent number: 8669250
    Abstract: The present invention concerns compounds of general formula (1) (I) wherein R1 is: —a hydrogen atom, or a halogen, —a straight or branched C1-C6 alkyl group or a C1-C3 fluoroalkyl group, —a straight or branched C1-C6 alcoxy group, a carbamyl group, N-substituted or not by one or two, straight or branched C1-C3 alkyl groups, or —a cyano group (CN) R2 is: —a hydrogen atom or a straight or branched C1-C6 alkyl group, HaI1, Hal2 and Hal3 are: —a halogen their addition salts and the hydrates of addition salts with pharmaceutically acceptable mineral acids or organic acids, and their enantiomer forms.
    Type: Grant
    Filed: June 3, 2010
    Date of Patent: March 11, 2014
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Francis Colpaert, Jean-Louis Maurel
  • Anhydrous crystalline vinflunine salts, method of preparation and use thereof as a drug and means of vinflunine purification
    Patent number: 8343991
    Abstract: The present invention relates to anhydrous crystalline vinflunine salts obtained with 1 or 2 equivalents of a pharmaceutically acceptable mineral or organic acid [Acid] 1 or 2 in which [Acid] represents hydrobromic, sulfuric, lactic and fumaric acids for the group of water-soluble crystalline salts, and para-toluene sulfonic, benzoic, mandelic and para-hydroxy benzoic acids for the group of relatively insoluble crystalline salts.
    Type: Grant
    Filed: February 13, 2008
    Date of Patent: January 1, 2013
    Assignee: Pierre Fabre Medicament
    Inventors: Jean-Louis Maurel, Richard Pena, Jean-Paul Ribet
  • NOVEL DERIVATIVES OF ARYL--METHANONE, THEIR METHOD OF PREPARATION AND THEIR USE AS MEDICINAL PRODUCTS
    Publication number: 20120115860
    Abstract: The present invention concerns compounds of general formula (1) (I) wherein R1 is: a hydrogen atom, or a halogen, a straight or branched C1-C6 alkyl group or a C1-C3 fluoroalkyl group, a straight or branched C1-C6 alcoxy group, a carbamyl group, N-substituted or not by one or two, straight or branched C1-C3 alkyl groups, or a cyano group (CN) R2 is: a hydrogen atom or a straight or branched C1-C6 alkyl group, HaI1, Hal2 and Hal3 are: a halogen their addition salts and the hydrates of addition salts with pharmaceutically acceptable mineral acids or organic acids, and their enantiomer forms.
    Type: Application
    Filed: June 3, 2010
    Publication date: May 10, 2012
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Bernard Vacher, Francis Colpaert, Jean-Louis Maurel
  • Process for the synthesis of N-[3-[(2-methoxyphenyl] sulfanyl] -2-methylpropyl] -3,4-dihydro-2H-1,5-benzoxathiepin-3-amine
    Patent number: 7982054
    Abstract: The invention relates to a new process for the preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine.
    Type: Grant
    Filed: November 6, 2007
    Date of Patent: July 19, 2011
    Assignee: Pierre Fabre Medicament
    Inventors: Bernard Vacher, Yves Brunel, Jean-Louis Maurel
  • ANHYDROUS CRYSTALLINE VINFLUNINE SALTS, METHOD OF PREPARATION AND USE THEREOF AS A DRUG AND MEANS OF VINFLUNINE PURIFICATION
    Publication number: 20100029703
    Abstract: The present invention relates to anhydrous crystalline vinflunine salts obtained with 1 or 2 equivalents of a pharmaceutically acceptable mineral or organic acid [Acid] 1 or 2 in which [Acid] represents hydrobromic, sulfuric, lactic and fumaric acids for the group of water-soluble crystalline salts, and para-toluene sulfonic, benzoic, mandelic and para-hydroxy benzoic acids for the group of relatively insoluble crystalline salts.
    Type: Application
    Filed: February 13, 2008
    Publication date: February 4, 2010
    Applicant: Pierre Fabre Medicament
    Inventors: Jean-Louis Maurel, Richard Pena, Jean-Paul Ribet
  • PROCESS FOR THE SYNTHESIS OF N-[3-[(2-METHOXYPHENYL] SULFANYL] -2-METHYLPROPYL] -3,4-DIHYDRO-2H-1,5-BENZOXATHIEPIN-3-AMINE.
    Publication number: 20090318709
    Abstract: The invention relates to a new process for the preparation of N-[3-[(2-methoxyphenyl)sulfanyl]-2-methylpropyl]-3,4-dihydro-2H-1,5-benzoxathiepin-3-amine.
    Type: Application
    Filed: November 6, 2007
    Publication date: December 24, 2009
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Bernard Vacher, Yves Brunel, Jean-Louis Maurel
  • Crystalline Form of Vinflunine Ditartrate
    Publication number: 20090247564
    Abstract: The present invention relates to a novel crystalline form of vinflunine, to a process for preparing it, and to its uses in the therapeutic field, in particular for treating cancer.
    Type: Application
    Filed: December 18, 2006
    Publication date: October 1, 2009
    Inventors: Jean-Louis Maurel, Richard Pena, Jean-Paul Ribet
  • Aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments
    Patent number: 7547700
    Abstract: The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.
    Type: Grant
    Filed: June 18, 2003
    Date of Patent: June 16, 2009
    Assignee: PIERRE Fabre Medicament
    Inventors: Bernard Vacher, Bernard Bonnaud, Jean-Louis Maurel, Francis Colpaert
  • Method for Preparing (3-Chloro-4-Fluorophenyl)-(4-Fluoro-4--Piperidin-1-Yl)-Methanone and Novel Intermediate Pyrimidine Derivatives
    Publication number: 20090118507
    Abstract: The present invention concerns the method for preparing (3-chloro-4-fluorophenyl)-(4-fluoro-4-{[(5-methyl-pyrimidin-2-ylmethyl)-amino]-methyl}-piperidin-1-yl)-methanone of formula (II) by condensation between 5-methyl-pyrimidin-2-methylamine of formula (I) and cyanohydrin of formula (III).
    Type: Application
    Filed: September 22, 2006
    Publication date: May 7, 2009
    Applicant: PIERRE FABRE MEDICAMENT
    Inventors: Bernard Vacher, Jean-Louis Maurel, Serge Brunel
  • Synthesis method and intermediates of pyridin-2-yl-methylamine
    Patent number: 7208603
    Abstract: The invention concerns a novel method for preparing pyridin-2-yl-methylamine derivatives by reducing amination of cyanohydrins.
    Type: Grant
    Filed: February 11, 2002
    Date of Patent: April 24, 2007
    Assignee: Pierre Fabre Medicament
    Inventors: Jean-Louis Maurel, Bernard Bonnaud, Jean-Paul Ribet, Bernard Vacher
  • Novel aryl-[4-halo-4(heteroarylmethylamino)-methyl]-piperidin-1-1yl]-methanone derivatives, methods for production and use thereof as medicaments
    Publication number: 20060100244
    Abstract: The invention relates to compounds of general formula (1) in which X and Y=a carbon with a bonded hydrogen atom (CH) or a nitrogen atom, A=a methyl, fluoromethyl, cyano, hydroxyl, methoxy group, or a chlorine or fluorine atom on condition that when A=methyl (CH3) and X and Y both=a carbon bonded to a hydrogen atom, then B=a chlorine atom, B=a chlorine or a fluorine atom, D=a hydrogen, chlorine, fluorine atom, or a cyano or trifluoromethyl group and E=a hydrogen, fluorine or chlorine atom.
    Type: Application
    Filed: June 18, 2003
    Publication date: May 11, 2006
    Inventors: Bernard Vacher, Bernard Bonnaud, Jean-Louis Maurel, Francis Colpaert
  • Synthesis method and intermediates of pyridin-2-yl-methylamine
    Publication number: 20040116705
    Abstract: The invention concerns a novel method for preparing pyridin-2-yl-methylamine derivatives by reducing amination of cyanohydrins.
    Type: Application
    Filed: January 27, 2004
    Publication date: June 17, 2004
    Inventors: Jean-Louis Maurel, Bernard Bonnaud, Jean-Paul Ribet, Bernard Vacher