Patents by Inventor Jean-Louis Pépin
Jean-Louis Pépin has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20240050030Abstract: A process for determining a patient's apnoea+hypopnoea index or statis dependent on this index, including supplying a data set relating to a patient having, or making it possible to determine, characteristic data of the patient's maxillofacial morphology. The determination of the characteristic data is dependent on the positioning of at least four homologous points (1100, 1110), on a 3D scan of the head (60) of the patient (6). The process includes introducing this set into a machine learning model, trained to predict the apnoea+hypopnoea index, or the status, for the data set, from a database of different patients including maxillofacial morphology data, associated with an apnoea+hypopnoea index, or a status dependent on an apnoea+hypopnoea index, such that the model predicts an apnoea+hypopnoea index or a status for the data set relating to the patient.Type: ApplicationFiled: December 17, 2021Publication date: February 15, 2024Inventors: Lionel SANCHEZ, Fabrice MONNA, Jean-Louis PEPIN
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Patent number: 10307328Abstract: A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.Type: GrantFiled: February 9, 2015Date of Patent: June 4, 2019Assignees: SORIN CRM SAS, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ RENNES 1Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10299984Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.Type: GrantFiled: December 7, 2015Date of Patent: May 28, 2019Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10292897Abstract: A system includes a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.Type: GrantFiled: December 7, 2015Date of Patent: May 21, 2019Assignees: SORIN CRM SAS, INSERM—INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉ DE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10292898Abstract: A device includes a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.Type: GrantFiled: December 7, 2015Date of Patent: May 21, 2019Assignees: SORIN CRM SAS, INSERM-INSTITUT DE LA RECHERCHE MÉDICALE, UNIVERSITÉ JOSEPH FOURIER, UNIVERSITÉDE RENNES 1Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 10251809Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller. The controller is configured to determine a sleep state of the patient, adaptively control the generator based on the sleep state where the sleep state includes a plurality of sleep stages, and modulate a stimulation energy of the stimulation pulses produced by the generator based on the sleep stage of the patient.Type: GrantFiled: February 9, 2015Date of Patent: April 9, 2019Assignees: Sorin CRM SAS, INSERM—INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE, UNIVERSITÉ DE RENNES 1, UNIVERSITE JOSEPH FOURIER—GRENOBLE 1Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20180184945Abstract: A method and device for detecting a worsening of the cardiopulmonary state of a patient treated by a respiratory assistance device comprising means for gathering and processing parameters which are representative of a first parameter that is representative of the patient's respiratory frequency over a first observation window, e.g. daily; a second parameter that is representative of the percentage of cycles that were initiated by the patient during a second observation window, e.g. daily; and a third parameter that is representative of the usage time of the device during a third observation window, e.g. daily.Type: ApplicationFiled: June 4, 2015Publication date: July 5, 2018Inventors: Jean-Christian BOREL, Nellie TALEUX-EYSSAUTIER, Nathalie ARNOL, Renaud TAMISIER, Jean Louis PÉPIN
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Publication number: 20170296766Abstract: A breathable gas supply regulation device of gas supplied by a respiratory assistance apparatus in breath assistance comprising a first input receiving a leakage signal produced by a detection member. The device regulates the supply of breathable gas to the patient in response to a received leakage signal, comprises a second input receiving a patient mouth movement measurement signal. The device comprises a processing unit provided for generating a synchronisation signal between the movement signal and the leakage signal. The processing unit generates a modification amount indicating the modification to be applied to the supply of breathable gas.Type: ApplicationFiled: September 18, 2015Publication date: October 19, 2017Applicant: NOMICSInventors: Pierre ANSAY, Bernard BECKERS, Jean-Christian BOREL, Jean-Louis PEPIN
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Publication number: 20160158091Abstract: The disclosure relates to a system including a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a disappearance of the respiratory disorder. The processor is further configured to determine a therapy by selecting a stimulation strategy among several stimulation strategies according to a type of expected or detected disorder.Type: ApplicationFiled: December 7, 2015Publication date: June 9, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20160158092Abstract: The disclosure relates to a system including a processor configured to generate stimulation control signals in response to a detection of a respiratory disorder. The system further includes at least one kinesthetic effector with a vibrating electromechanical transducer applied to a site on a patient's skin for delivering a kinesthetic stimulation energy determined by the control signals. The processor is further configured to determine the effectiveness of a stimulation by detecting a cessation of the respiratory disorder. The processor is further configured to extend the stimulation control signals for a determined duration following the cessation of the respiratory disorder.Type: ApplicationFiled: December 7, 2015Publication date: June 9, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20160158093Abstract: The disclosure relates to a device including a processor configured to detect a respiratory disorder episode and generate kinesthetic stimulation control signals in response to the detection of a respiratory disorder episode. The device further includes at least one kinesthetic effector adapted to be applied to a patient's outer skin site and includes a vibrating electromechanical transducer capable of receiving stimulation control signals and outputting a kinesthetic stimulation energy determined by the stimulation control signals. The processor is further configured to determine the effectiveness of stimulation by detecting a cessation of the respiratory disorder episode. The processor is further configured to determine a stimulation energy by selecting an initial energy value and varying the energy value as a function of the effectiveness of previous stimulation.Type: ApplicationFiled: December 7, 2015Publication date: June 9, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20160113571Abstract: The invention relates to an active implantable medical device. The device measures for respiratory activity and for detection of a ventilation rate fall event below a predetermined threshold. The device analyzes in real time the various parameters of the ventilation rate fall event and determines whether they satisfy predefined criteria, so as to allocate or not a priori hypopnea suspicion indicator to the event. An anti-hypopnea therapy is selectively triggered on detection of respiratory collapse, but only in the case of current events indicating a priori hypopnea suspicion. The criteria may include: history of intervals between successive events constituting hypopnea episodes; severity of the current event; conformity of a current event profile with a reference profile; physiological, obstructive or central, origin of the event; patient's current sleep stage; and history of the degree of efficacy of the therapies.Type: ApplicationFiled: October 26, 2015Publication date: April 28, 2016Inventors: Amel Amblard, Laurence Graindorge, Delphine Feuerstein, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20150224017Abstract: A device for treating sleep apnea by discriminating between successive sleep stages of a patient includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, a sensor configured to measure a biological parameter of the patient, and a controller. The controller is configured to determine a state of the patient based on the biological parameter, perform a sleep analysis based on the state of the patient, activate the generator to trigger production of the stimulation pulses, determine a variation of the biological parameter subsequent to the production of the stimulation pulses, determine a response of the patient to the stimulation pulses according to the variation of the biological parameter, and determine a sleep stage of the patient based on the response.Type: ApplicationFiled: February 9, 2015Publication date: August 13, 2015Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Publication number: 20150224018Abstract: A device for treating sleep apnea in a patient through stimulation. The device includes a generator configured to produce stimulation pulses, a stimulator that receives the stimulation pulses produced by the generator and delivers stimulation to the patient, and a controller.Type: ApplicationFiled: February 9, 2015Publication date: August 13, 2015Inventors: Laurence Graindorge, Amel Amblard, Christine Henry, Marcel Limousin, Laure Duchemin Laporte, Alfredo Hernandez, Jean-Louis Pépin
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Patent number: 6916287Abstract: To assess the sensitivity of a subject's pharynx, an open mouthpiece (1) fitted with a thin guide tube (2), having an articulated end (4), is inserted into the subject's mouth. A pipe (9) is inserted into the guide tube, under visual observation through the mouthpiece, until it touches the subject's palate. The position on a measurement scale (11) provided on the pipe facing a second end of the guide tube is noted, and the pipe is withdrawn over a preset distance, for example 1 cm, and fixed in this position onto the guide tube. A variable gas flow is injected into the pipe and reaches the pharyngeal mucous situated facing the pipe. The sensitivity of the subject's pharynx, measured by the threshold of sense perception, is determined by the lowest flow value perceived by the subject.Type: GrantFiled: May 13, 2002Date of Patent: July 12, 2005Assignee: Universite Joseph FourierInventors: Maurice Dematteis, Jean-Louis Pepin, Patrick Levy
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Publication number: 20040138585Abstract: To assess the sensitivity of a subject's pharynx, an open mouthpiece (1) fitted with a thin guide tube (2), having an articulated end (4), is inserted into the subject's mouth. A pipe (9) is inserted into the guide tube, under visual observation through the mouthpiece, until it touches the subject's palate. The position on a measurement scale (11) provided on the pipe facing a second end of the guide tube is noted, and the pipe is withdrawn over a preset distance, for example 1 cm, and fixed in this position onto the guide tube. A variable gas flow is injected into the pipe and reaches the pharyngeal mucous situated facing the pipe. The sensitivity of the subject's pharynx, measured by the threshold of sense perception, is determined by the lowest flow value perceived by the subject.Type: ApplicationFiled: December 24, 2003Publication date: July 15, 2004Inventors: Maurice Dematteis, Jean-Louis Pepin, Patrick Levy