Abstract: This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R1-R3 are as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and R1 is selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and C1-6haloalkyl group.

Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.

Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.

Abstract: This invention relates to a purine or pyrimidine phosphonate compound of formula (I) or pharmaceutically acceptable salt thereof; wherein B, X, and R1-R3 are as defined in classes and subclasses herein. These compounds may be used as antiviral precursors. The invention also relates to therapeutic compositions of these compounds and their use for the preparation of a medication for testing and/or preventing a viral infection in a patient. The invention also provides methods for making these compounds. In particular, the invention provides an H-phosphinate precursor intermediate of formula (II) wherein B is a purine or pyrimidine base as defined herein and R1 is selected from the group comprising a hydrogen atom, and a methyl, ethyl, hydroxymethyl, hydroxyethyl and C1-6haloalkyl group.

Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.

Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.

Abstract: This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of flavivirus (CEF). The invention also concerns the use of such polypeptide to identify biologically active molecule wich can be used in the treatment or the prevention of diseases resulting from Flavivirus infection.

Abstract: This invention concerns an isolated and purified polypeptide capable of acting as a guanylyltransferase and methyltransferase comprising capping enzyme of flavivirus (CEF). The invention also concerns the use of such polypeptide to identify biologically active molecule wich can be used in the treatment or the prevention of diseases resulting from Flavivirus infection.

Abstract: The present invention relates to a cell construct cultured in vitro characterized in that it comprises (i) animal cells cultured in vitro in conditions ensuring formation of a three-dimensional tissue structure and (ii) an endogenous extracellular matrix in which said cells are imprisoned, and in that it comprises, among said cells, cells having a mineralization and/or ossification capacity. The invention is particularly useful in the fields of grafts and implantology (tissue reconstruction or repair), as well as in the pharmaceutical industry, for research on tissue and analysis of the toxic or beneficial profile of molecules capable of being used in pharmaceutics development and/or pharmaceutical compositions.

Abstract: The isolation and purification of two domains from a from a flavivirus is provided. Each domain can function independently. Moreover, one domain codes for a sequence that provide polymerase activity. A process for screening possible modulators of the polymerase activity of an isolated and purified polypeptide from flavivirus is also disclosed.

Abstract: A device for preserving sterility during the taking of samples for analysis from culture medium containers. This device comprises a holder containing a sampling chamber which encloses a sliding piston fitted at one end with a toric cavity for removal of the sample for analysis, and a dilution chamber linked to the first chamber by a duct. The second chamber is divided into two parts by a central bearing and contains two sliding pistons which may abut respectively the opposite sides of the bearing. The second chamber comprises an inlet for the dilution solvent.

Abstract: The measuring cell is composed of at least one cavity hollowed in a block of chemically inert material or material made chemically inert at least at the surface. The cavity defines a first cylindrical space whose bottom is, over a reduced part of its diameter, extended by a second space defining the measuring chamber proper, of conical, frustoconical or substantially hemispherical shape. The first cylindrical space is designed to receive a measuring electrode terminated by a magnetic torus and, applied, and if necessary held by means of a ferromagnetic ring, against the latter, a membrane, while inlet and outlet ducts for the liquids to be assayed are formed in the block. The cell is especially useful for micro-assays of biological fluids.