Patents by Inventor Jean Louise Helom

Jean Louise Helom has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 8609712
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Grant
    Filed: September 14, 2012
    Date of Patent: December 17, 2013
    Assignee: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Publication number: 20130012702
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Application
    Filed: September 14, 2012
    Publication date: January 10, 2013
    Applicant: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Patent number: 8309594
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Grant
    Filed: February 12, 2009
    Date of Patent: November 13, 2012
    Assignee: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Patent number: 8129523
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Grant
    Filed: September 26, 2008
    Date of Patent: March 6, 2012
    Assignee: Wyeth LLC
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Jean Louise Helom
  • Patent number: 7786297
    Abstract: Micronized tanaproget, purified tanaproget Form I, and micronized, purified tanaproget Form I are provided. Also provided are compositions containing one or more of the prepared tanaproget forms, methods of using one or more of the prepared tanaproget forms, and kits containing one or more of the prepared tanaproget forms.
    Type: Grant
    Filed: April 26, 2006
    Date of Patent: August 31, 2010
    Assignee: Wyeth LLC
    Inventors: Ramarao Chatlapalli, Arwinder Nagi, John Potoski, Jean Louise Helom, Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Vladimir Dragan
  • Publication number: 20090143577
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B, X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Application
    Filed: February 12, 2009
    Publication date: June 4, 2009
    Applicant: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Patent number: 7514466
    Abstract: Methods for purifying a compound of formula I are provided, wherein A, B X, Q, and R1 are defined herein. The methods include mixing the compound of formula I and a solvent; adding a base to the solvent; and precipitating purified compound of formula I.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: April 7, 2009
    Assignee: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Anthony Francis Hadfield, Jean Louise Helom
  • Publication number: 20090054663
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Application
    Filed: September 26, 2008
    Publication date: February 26, 2009
    Applicant: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Jean Louise Helom
  • Patent number: 7446211
    Abstract: A convenient preparation of boron-containing compounds, borate salts, pyrrolecarbonitrile boron-containing compounds, N-substituted-pyrrole-2-carbonitrile boron-containing compounds, and derivatives thereof is provided. The present invention also provides for the use of these boron-containing compounds and derivatives thereof in coupling reactions to provide bi-aryl compounds.
    Type: Grant
    Filed: April 25, 2005
    Date of Patent: November 4, 2008
    Assignee: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Arkadiy Zinoviy Rubezhov, Jean Louise Helom
  • Patent number: 7399870
    Abstract: The instant invention concerns processes for the production of pyrrole-2-carbonitriles such as 1-methylpyrrole-2-carbonitrile. Such processes preferably comprise the steps of reacting a pyrrole with chlorosulfonyl isocyanate in the presence of a solvent and contacting the resulting product with a molar excess of an amide such as N,N-dimethylformamide. The product of this contacting step is then contacted with a molar excess of an organic base to produce a precipitate and a solution phase. The precipitate is then separated from the solution phase and the corresponding pyrrole-2-carbonitrile is isolated from the resulting solution phase.
    Type: Grant
    Filed: March 22, 2005
    Date of Patent: July 15, 2008
    Assignee: Wyeth
    Inventors: Jean Louise Helom, Arkadiy Zinoviy Rubezhov, Anthony Scott Pilcher, Bogdan Kazimierz Wilk
  • Patent number: 7323483
    Abstract: The present invention provides processes for the preparation of substituted naphthylindole derivatives that can be used as inhibitors of plasminogen activator inhibitor-1(PAI-1). In certain embodiments of the invention, the processes involve reactions that include one or more of an Oppenauer oxidation, a Fischer indole synthesis, a methyl ether cleavage, or coupling a substituted methyltetrazole with a substituted naphthol.
    Type: Grant
    Filed: January 25, 2006
    Date of Patent: January 29, 2008
    Assignee: Wyeth
    Inventors: Vladimir A. Dragan, John Richard Potoski, Wayne G. McMahon, Jean Louise Helom, Xinxu Shi
  • Patent number: 7122705
    Abstract: Processes for coupling phenol and cycloalkyls including combining an optionally substituted phenol, a cycloalkyl substituted with a leaving group, carbonate salt, tetrahydrofuran, and an optional phase transfer agent are provided. Also provided are processes for preparing 3-cyclopentyloxy-4-methoxybenzaldehyde by combining 3-hydroxy-4-methoxybenzaldehyde, a cyclopentyl compound, a carbonate salt, a solvent, and an optional phase transfer agent.
    Type: Grant
    Filed: April 7, 2005
    Date of Patent: October 17, 2006
    Assignee: Wyeth
    Inventors: Bogdan Kazimierz Wilk, Nalukui Mwisiya, Jean Louise Helom