Patents by Inventor Jean-Luc Beulay
Jean-Luc Beulay has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Publication number: 20220347598Abstract: The invention relates to a method for purifying a target substance starting from a fluid to be treated which comprises at least one impurity. The method comprises treatment of a stream of the fluid to be treated using a chromatography step in a first separation unit, collection of a fraction enriched with the target substance in a first tank, and viral inactivation of the fraction enriched with the target substance. The viral inactivation comprises passing the fraction enriched with the target substance through a second separation unit, passing a viral inactivation solution through the second separation unit, mixing, and collecting the mixture in the second tank to obtain a fraction depleted of active virus. The method further comprises treatment of the fraction depleted of active virus using a chromatography step in the second separation unit and collection of a fraction more enriched with the target substance.Type: ApplicationFiled: July 24, 2020Publication date: November 3, 2022Inventors: Jérôme CHEVALIER, Jean-Luc BEULAY, Thomas FLOUQUET, Hélène LAFONTAINE
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Patent number: 9676069Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: GrantFiled: June 23, 2014Date of Patent: June 13, 2017Assignee: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 9592577Abstract: The invention concerns a filtration device comprising a providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: GrantFiled: June 23, 2014Date of Patent: March 14, 2017Assignee: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 9573230Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: GrantFiled: October 6, 2014Date of Patent: February 21, 2017Assignee: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Publication number: 20150020366Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: ApplicationFiled: October 6, 2014Publication date: January 22, 2015Inventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 8883003Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: GrantFiled: July 25, 2013Date of Patent: November 11, 2014Assignee: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 8877052Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: GrantFiled: May 12, 2011Date of Patent: November 4, 2014Assignee: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Publication number: 20140299531Abstract: The invention concerns a filtration device comprising a manifold providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: ApplicationFiled: June 23, 2014Publication date: October 9, 2014Inventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Publication number: 20140299530Abstract: The invention concerns a filtration device comprising a providing fluid connection and mechanical connection comprising a clamping plate movably mounted relative to the manifold and adapted to compress at least one cassette against the manifold, means for driving and guiding the clamping plate comprising a rod extending between the manifold and the plate, an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold, and the member carrying the rod and driving the plate via the rod to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: ApplicationFiled: June 23, 2014Publication date: October 9, 2014Inventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 8701704Abstract: The invention concerns a manifold comprising: an auxiliary block (3) having cassette feed ports (20) and cassette filtrate return ports (21) each emerging through a bearing surface (7) and, on a counter-bearing surface (8) situated on the opposite side to the bearing surface (7), first recesses into each of which emerges a cassette filtrate return port (21); a main block (2) on which is fastened the auxiliary block (3), having an inlet conduit (14) and a filtrate outlet conduit (15), cassette feed intermediate ports which communicate with the inlet conduit (14) and with a cassette feed port (20), conveying cut-outs each facing a recess, and cassette filtrate return intermediate ports which communicate with the filtrate outlet conduit (15) and with a cassette filtrate return port (21).Type: GrantFiled: May 12, 2011Date of Patent: April 22, 2014Assignee: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Publication number: 20130306539Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: ApplicationFiled: July 25, 2013Publication date: November 21, 2013Applicant: EMD Millipore CorporationInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 8557113Abstract: The cart comprises a lateral face by which it is adapted to be juxtaposed against another cart. It further comprises a first pump, a second pump disposed below said first pump and laterally offset relative thereto, and a tank adapted to receive a feed container provided to contain said biological liquid, said tank being disposed above said first pump and offset laterally relative thereto. The installation comprises one said cart, a filter and a second cart, juxtaposed against said first cart and of which the upper face supports said filter such that an outlet point of said first pump is situated substantially facing an inlet/outlet aperture of said filter.Type: GrantFiled: December 4, 2009Date of Patent: October 15, 2013Assignee: EMD Millipore CorporationInventors: Jean Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean Louis Weissenbach
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Patent number: 8506798Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).Type: GrantFiled: November 29, 2012Date of Patent: August 13, 2013Assignee: EMD Millipore CorporationInventors: Jean-Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean-Louis Weissenbach
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Publication number: 20130191729Abstract: In a method of processing data and generating an electronic report which can be printed on paper or displayed on a monitor screen, wherein the electronic report relates to operation characteristics of a system (1) which performs product manufacturing, processing and/or analysis steps and the data include a plurality of physical parameters which are characteristic of the operation of the system and are stored in a database (4), one of a plurality of report templates stored in a report template library (14) is selected. Each report template comprises at least one sub-report corresponding to a particular type of representation of data within an electronic report based on the respective report template (10) and including at least one data item, i.e. a reference to one of the physical parameters or to an arithmetic operation therewith and a static or dynamically assignable reference to a batch or time range.Type: ApplicationFiled: March 26, 2010Publication date: July 25, 2013Applicant: EMD MILLIPORE CORPORATIONInventors: Rene Reinbigler, Jean-Louis Weissenbach, Jean-Luc Beulay, Subbarao Kattamuri
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Patent number: 8343356Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).Type: GrantFiled: March 15, 2012Date of Patent: January 1, 2013Assignee: EMD Millipore CorporationInventors: Jean-Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean-Louis Weissenbach
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Publication number: 20120174996Abstract: The invention concerns a manifold comprising: an auxiliary block (3) having cassette feed ports (20) and cassette filtrate return ports (21) each emerging through a bearing surface (7) and, on a counter-bearing surface (8) situated on the opposite side to the bearing surface (7), first recesses into each of which emerges a cassette filtrate return port (21); a main block (2) on which is fastened the auxiliary block (3), having an inlet conduit (14) and a filtrate outlet conduit (15), cassette feed intermediate ports which communicate with the inlet conduit (14) and with a cassette feed port (20), conveying cut-outs each facing a recess, and cassette filtrate return intermediate ports which communicate with the filtrate outlet conduit (15) and with a cassette filtrate return port (21).Type: ApplicationFiled: May 12, 2011Publication date: July 12, 2012Applicant: MILLIPORE CORPORATIONInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Publication number: 20120168390Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).Type: ApplicationFiled: March 15, 2012Publication date: July 5, 2012Applicant: EMD MILLIPORE CORPORATIONInventors: Jean-Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean-Louis Weissenbach
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Publication number: 20120111782Abstract: The invention concerns a filtration device comprising a manifold (3) providing fluid connection and mechanical connection comprising a clamping plate (4) movably mounted relative to the manifold (3) and adapted to compress at least one cassette (2) against the manifold (3), means for driving and guiding the clamping plate comprising a rod (6) extending between the manifold (3) and the plate (4), an actuator provided with a body and a member moveable relative to the body, which member is adapted to move through a predetermined travel between an extended position and a retracted position, the body being carried by the manifold (3), and the member carrying the rod (6) and driving the plate (4) via the rod (6) to a clamped position in which the member is in an intermediate retracted position in which it has moved through a shorter travel than the predetermined travel relative to its extended position.Type: ApplicationFiled: May 12, 2011Publication date: May 10, 2012Applicant: MILLIPORE CORPORATIONInventors: Sebastien Cirou, Jean-Louis Weissenbach, Rene Reinbigler, Jean-Luc Beulay, Frans Mels, Cecile Delbos
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Patent number: 8163172Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).Type: GrantFiled: April 4, 2011Date of Patent: April 24, 2012Assignee: EMD Millipore CorporationInventors: Jean-Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean-Louis Weissenbach
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Publication number: 20110174716Abstract: Installation for treating a biological liquid, including a circulation pump (5), a filter element (9), a container for collecting treated liquid, a first circuit section connecting a source of said biological liquid to an inlet orifice of said filter element (9), including a circuit element adapted to cooperate with said circulation pump (5); a second circuit section, connecting an outlet orifice of said filter element (9) to said treated liquid collecting container; characterized in that said treated liquid collecting container, said first circuit section and said second circuit section are disposable and said installation further includes a first cart (1) carrying said pump (5) and a second cart (2) including a housing (14) for said collecting container, separable from the first cart (1) and adapted to be at least partly nested in said first cart (1).Type: ApplicationFiled: April 4, 2011Publication date: July 21, 2011Applicant: MILLIPORE CORPORATIONInventors: Jean-Luc Beulay, Virginie Buisson, Sebastien Cirou, Cecile Delbos, Marc Hlavacek, Frans Mels, Rene Reinbigler, Jean-Louis Weissenbach