Abstract: A method of operation of a compute system includes: receiving a patient image; segmenting a skin lesion in the patient image; constructing a normalized image by cropping the patient image and adding padding to position the skin lesion at the center of the normalized image; identifying, by a cancer artificial intelligence (AI) already trained, a skin cancer classification, a skin cancer sub-class, and a risk level assessment; and generating a skin cancer display including the normalized image, the skin cancer classification, the skin cancer sub-class, and the risk level assessment for displaying on a device.