Patents by Inventor Jean M. Alonso

Jean M. Alonso has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Method for obtaining protective active and inactive adenylate cyclase from Bordetella parapertussis
    Patent number: 5595901
    Abstract: A method for preparing an active and inactive adenylate cyclase from a culture of Bordetella parapertussis having specific reactivity with polyclonal or monoclonal antibodies to adenylate cyclase from Bordetella pertussis is presented. The inactive adenylate cyclase is devoid of calmodulin-activatable adenylate cyclase activity and of affinity for calmodulin. The method comprises culturing a clone of Bordetella parapertussis, homogenizing the culture to produce a homogenate, and isolating the active and inactive adenylate cyclase from the homogenate by urea precipitation. The isolated active and inactive adenylate cyclase may be used to prepare a vaccine for the prevention of Bordetella infection.
    Type: Grant
    Filed: June 6, 1995
    Date of Patent: January 21, 1997
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Murielle Rocancourt, Colette Brezin, Jean L. Boucaud, Marek Szatanik, Jean M. Alonso
  • A43 kDa antigenic protein of Bordetella recognized by polyclonal antibodies to adenylate cyclase but devoid of calmodulin-activatable adenylate cyclase activity
    Patent number: 5095094
    Abstract: The proteins of the invention are specifically recognized by polyclonal anti-AC antibodies raised against purified AC preparations, devoid of adenylate cyclase CaM-activable activity and devoid of affinity for CaM.
    Type: Grant
    Filed: February 20, 1990
    Date of Patent: March 10, 1992
    Assignees: Institut Pasteur, Institut National de la Sante et de la Recherche Medicale
    Inventors: Colette Brezin, Hoang-Oanh Nghiem, Jean Luc Boucaud, Jean M. Alonso