Patents by Inventor Jean M. Bidlack

Jean M. Bidlack has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Compositions and methods for inhibiting G protein signaling
    Patent number: 8975259
    Abstract: Disclosed are compositions and methods for treating diseases associated with G protein ?? subunit activity.
    Type: Grant
    Filed: April 28, 2008
    Date of Patent: March 10, 2015
    Assignee: University of Rochester
    Inventors: Alan V Smrcka, Burns C. Blaxall, Jean M. Bidlack
  • COMPOSITIONS AND METHODS FOR INHIBITING G PROTEIN SIGNALING
    Publication number: 20100130505
    Abstract: Disclosed are compositions and methods for treating diseases associated with G protein ?? subunit activity.
    Type: Application
    Filed: April 28, 2008
    Publication date: May 27, 2010
    Applicant: University of Rochester
    Inventors: Alan V. Smrcka, Burns C. Blaxall, Jean M. Bidlack
  • Treatment of cocaine abuse using N-substituted derivatives of morphinan
    Patent number: 7291628
    Abstract: The invention is based in part on the discovery that nonselective ? agonists that possess ? receptor-mediated effects in addition to their ? agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective ? agonists. The invention includes a number of new compounds having both nonselective ? opioid receptor agonist activity and additional activity at ? opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as imaging agents, e.g., the N-fluoroalkyl and iodoalkyl derivatives can be used, respectively, for positron emission tomography (PET) and single photon computed tomography (SPECT) brain imaging.
    Type: Grant
    Filed: January 4, 2005
    Date of Patent: November 6, 2007
    Assignee: McLean Hospital Corporation
    Inventors: John L. Neumeyer, Jean M. Bidlack, Xiao-Hui Gu
  • N-substituted derivatives of morphinan and uses thereof
    Patent number: 6844438
    Abstract: The invention is based in part on the discovery that nonselective ? agonists that possess ? receptor-mediated effects in addition to their ? agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective ? agonists. The invention includes a number of new compounds having both nonselective ? opioid receptor agonist activity and additional activity at ? opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as imaging agents, e.g., the N-fluoroalkyl and iodoalkyl derivatives can be used, respectively, for positron emission tomography (PET) and single photon computed tomography (SPECT) brain imaging.
    Type: Grant
    Filed: August 15, 2002
    Date of Patent: January 18, 2005
    Assignees: McLean Hospital Corporation, University of Rochester
    Inventors: John L. Neumeyer, Jean M. Bidlack, Xiao-Hui Gu
  • N-substituted derivatives of morphinan and uses thereof
    Publication number: 20030073716
    Abstract: The invention is based in part on the discovery that nonselective &kgr; agonists that possess &mgr; receptor-mediated effects in addition to their &kgr; agonist effects can decrease cocaine self-administration more effectively and with fewer undesirable side effects than can highly selective &kgr; agonists. The invention includes a number of new compounds having both nonselective &kgr; opioid receptor agonist activity and additional activity at &mgr; opioid receptors. These compounds are useful for the treatment of cocaine abuse, and can also be radiolabeled for use as imaging agents, e.g., the N-fluoroalkyl and iodoalkyl derivatives can be used, respectively, for positron emission tomography (PET) and single photon computed tomography (SPECT) brain imaging.
    Type: Application
    Filed: August 15, 2002
    Publication date: April 17, 2003
    Inventors: John L. Neumeyer, Jean M. Bidlack, Xiao-Hui Gu
  • Immunoassay of free kappa light chains for the detection of multiple sclerosis
    Patent number: 4792529
    Abstract: Multiple sclerosis (MS) is diagnosed by determining with a quantitative immunoassay the quantity of free kappa light chains in the cerebrospinal fluid of a patient. The immunoassay is preferably a radioimmunoassay. In carrying out the immunoassay, the free kappa light chains are combined with antiserum specific thereto. This method of diagnosing MS has high sensitivity in distinguishing between normal patients and patients affected with MS.
    Type: Grant
    Filed: October 18, 1985
    Date of Patent: December 20, 1988
    Assignee: University of Rochester
    Inventors: Richard A. Rudick, Robert M. Herndon, Jean M. Bidlack