Abstract: The present invention relates to a method for identifying a relationship between biological elements, said elements optionally having a measurable activity, the method comprising the following steps: defining candidate graphs, each candidate graph being a graph associated with one of the thresholding values from the plurality of thresholding values, for each thresholding value, obtaining a distribution associated by optimization of the distribution into classes of the apices of the graph associated with the relevant thresholding value, the optimization starting with an initial distribution in which with each core is associated a class for obtaining a final distribution in which each apex of a class shares more links with the other apices of the same class than with the apices of another class, selecting an optimum graph from among the plurality of candidate graphs according to at least one criterion.