Abstract: This invention relates to compounds of formula (X) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (X) to treat necroptosis and/or inhibit and/or degrade MLKL.

Abstract: This invention relates to compounds of formula (X) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (X) to treat necroptosis, and/or inhibit and/or degrade MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compound of formula (I) to treat necroptosis and/or inhibit RIP1 and/or MLKL.

Abstract: This invention relates to compounds of formula (I) and salts, solvates, tautomers, N-oxides, stereoisomers, polymorphs and/or prodrugs thereof. Also disclosed is the use of the compounds of formula (I) to treat necroptosis and/or inhibit MLKL.

Abstract: Process for constructing a volume mesh of a subsurface formation comprising at least one sedimentary layer traversed by at least one fault. On the basis of a representation in a closed domain of the geometry of the horizons and of the faults in a parametric space before deformation and rupture, the bounds of the blocks delimited by the faults, the horizons and the boundaries of the domain are projected onto a reference surface. Next a surface mesh is constructed constrained by the projections thus obtained on the reference surface. At each node of the surface mesh, a vertical polygonal line passing through this node is defined. Next a volume mesh is constructed by vertical extrusion of the surface mesh along the polygonal lines. Application in particular to exploration and to exploitation of oilfields.

Abstract: The invention relates to a method for exploiting (EXP) a subsurface deposit comprising at least one outcrop, the exploitation (EXP) of the deposit is based on a geological model (MOD) formed from a photogrammetry. The method reconstructs the geological outcrops in three dimensions (R3D) from photographs (PHO), and interprets the geological elements thereof, such as the sedimentary surfaces, the geological facies, the fault lines and the fractures, the inclination of the beds, etc. to construct a geological model of the deposit (MOD).

Abstract: Process for constructing a volume mesh of a subsurface formation comprising at least one sedimentary layer traversed by at least one fault. On the basis of a representation in a closed domain of the geometry of the horizons and of the faults in a parametric space before deformation and rupture, the bounds of the blocks delimited by the faults, the horizons and the boundaries of the domain are projected onto a reference surface. Next a surface mesh is constructed constrained by the projections thus obtained on the reference surface. At each node of the surface mesh, a vertical polygonal line passing through this node is defined. Next a volume mesh is constructed by vertical extrusion of the surface mesh along the polygonal lines. Application in particular to exploration and to exploitation of oilfields.

Abstract: An airbeam includes at least a pair of inflatable beams each having an inner sleeve, middle sleeve and outer cover. Each sleeve is stitched to form flat side seams. The sleeves are inverted so that each flat side seam is disposed cantilevered inwardly on the inside of the sleeve. A linear common seam bisects the stitched side edges of the outer cover to form a pair of outer sleeves. One middle sleeve is nested within each outer sleeve. One inner sleeve is nested within each middle sleeve. One inner tube is nested in each inner sleeve. The nesting is arranged so that the side seams of the inner and middle sleeves are adjacent one another or overlap one another along, their entire length and so that the side seams of the outer cover are adjacent or overlap the side seams of the middle sleeve.

Abstract: The invention relates to a method for exploiting (EXP) a subsurface deposit comprising at least one outcrop, the exploitation (EXP) of the deposit is based on a geological model (MOD) formed from a photogrammetry. The method reconstructs the geological outcrops in three dimensions (R3D) from photographs (PHO), and interprets the geological elements thereof, such as the sedimentary surfaces, the geological facies, the fault lines and the fractures, the inclination of the beds, etc. to construct a geological model of the deposit (MOD).

Abstract: An airbeam includes at least a pair of inflatable beams each having an inner sleeve, middle sleeve and outer cover. Each sleeve is stitched to form flat side seams. The sleeves are inverted so that each flat side seam is disposed cantilevered inwardly on the inside of the sleeve. A linear common seam bisects the stitched side edges of the outer cover to form a pair of outer sleeves. One middle sleeve is nested within each outer sleeve. One inner sleeve is nested within each middle sleeve. One inner tube is nested in each inner sleeve. The nesting is arranged so that the side seams of the inner and middle sleeves are adjacent one another or overlap one another along, their entire length and so that the side seams of the outer cover are adjacent or overlap the side seams of the middle sleeve.

Abstract: The invention is a method of constructing a three-dimensional fracture density log of a porous formation traversed by fractures and a borehole. A number N of intersections between the fractures and the borehole is measured over a section of the borehole of length L located at a depth d, from observations of the wall of this section. A conditional probability law of the three-dimensional fracture density is then estimated, knowing the number N of intersections. The value of the three-dimensional fracture density at depth d is determined by calculating the mean of this conditional probability law. Finally, the three-dimensional fracture density log is constructed by repeating the previous stages for different depths. A three-dimensional fracture density uncertainty log can also be associated by calculating quantiles of the conditional probability law.

Abstract: A method for mapping a complex sedimentary basin is disclosed. A grid representative of the current architecture of the basin is constructed. A mechanical structural restoration is applied in three dimensions so as to reconstruct the past architectures of the basin from the current time up to a geological time t. A simulation of the geological and geochemical processes that govern the formation of a petroleum reservoir is then carried out, directly in the grids obtained from the restoration, from the geological time t to the current one. This simulation is thereafter used for mapping the sedimentary basin so as to identify zones of the basin where hydrocarbons may have accumulated.

Abstract: An inflatable frame using, in each beam of the structure twinned tubes or otherwise multiple adjacent parallel tubes in each beam. The frame may be used for a sport ball arresting structure for supporting a mesh netting to enclose a player using full-swing, full power hitting of a sport ball into the mesh.

Abstract: A method for mapping a complex sedimentary basin is disclosed. A grid representative of the current architecture of the basin is constructed. A mechanical structural restoration is applied in three dimensions so as to reconstruct the past architectures of the basin from the current time up to a geological time t. A simulation of the geological and geochemical processes that govern the formation of a petroleum reservoir is then carried out, directly in the grids obtained from the restoration, from the geological time t to the current one. This simulation is thereafter used for mapping the sedimentary basin so as to identify zones of the basin where hydrocarbons may have accumulated.

Abstract: A pneumatically inflatable structure includes first and second parallel spaced apart pneumatic end support tubes and at least two opposed pairs of bowed criss-crossed pneumatic bracing tubes and an arched canopy extending over the support tubes and bracing tubes. Each of the end support tubes has first and second opposed ends each mountable to a base surface wherein each of the end support tubes forms a vertical arch having an apex when the structure is erect. The pneumatic bracing tubes have first and second ends wherein each of the first ends of the bracing tubes are secured to one of the first or second ends of one of the first or second end support tubes. Each of the second ends of the pneumatic bracing tubes are securable to substantially the apex or thereabouts of an opposed tube of the first or second end support tubes.

Abstract: The invention is a method of constructing a three-dimensional fracture density log of a porous formation traversed by fractures and a borehole. A number N of intersections between the fractures and the borehole is measured over a section of the borehole of length L located at a depth d, from observations of the wall of this section. A conditional probability law of the three-dimensional fracture density is then estimated, knowing the number N of intersections. The value of the three-dimensional fracture density at depth d is determined by calculating the mean of this conditional probability law. Finally, the three-dimensional fracture density log is constructed by repeating the previous stages for different depths. A three-dimensional fracture density uncertainty log can also be associated by calculating quantiles of the conditional probability law.

Abstract: A pneumatically inflatable structure includes first and second parallel spaced apart pneumatic end support tubes and at least two opposed pairs of bowed criss-crossed pneumatic bracing tubes and an arched canopy extending over the support tubes and bracing tubes. Each of the end support tubes has first and second opposed ends each mountable to a base surface wherein each of the end support tubes forms a vertical arch having an apex when the structure is erect. The pneumatic bracing tubes have first and second ends wherein each of the first ends of the bracing tubes are secured to one of the first or second ends of one of the first or second end support tubes. Each of the second ends of the pneumatic bracing tubes are securable the apex of an opposed of the first or second end support tubes.

Abstract: A segmented inflatable beam truss includes at least first, second and third separate inflatable beams mounted or mountable to one another and having, respectively, first, second and third lengths and a substantially constant diameter among all of the three beams. Each beam of the three separate beams includes an outer flexible substantially non-resilient sleeve along the entire length of the beam and an inner inflatable bladder extending substantially entirely along and in the entire length of the sleeve.

Abstract: An inflatable tent for mounting into the bed of a pickup truck. The tent includes at least one inflatable beam having opposite ends and extending, when mounted at its opposite ends to the bed, from a front of the bed to the rear of the bed. A flexible tent canopy is mounted to the inflatable beams. Each inflatable beam forms a substantially ogive shape when viewed in side elevation when inflated and mounted into the bed so as to dispose the opposite ends in releasably mounted engagement secured to interior opposite ends of the bed.