Abstract: An intra-orbital implant (1) is made by integrally coating a spherical core (36) with a preferably flexible, bio-compatible synthetic material by means of a uniform layer (3) of a microporous, bio-compatible synthetic material intimately mated to the spherical core (36). The layer (3) is formed, for example, by two identical strips (6, 7) of the material, disposed according to mutually perpendicular median planes (18, 19) each containing the spherical center of the core, the strips being joined to each other edge-to-edge. Used after enucleation or evisceration, such implants permit colonization by the natural tissue, thereby avoiding the risk of rejection.