Abstract: Method of cancer treatment by controlling cellular p53 protein levels. The invention concerns, in particular, the use of a compound capable of modulating calpaine activity.

Abstract: Method of cancer treatment by controlling cellular p53 protein levels. The invention concerns, in particular, the use of a compound capable of modulating calpaine activity.

Abstract: The ball anchoring device consists of a lock body (10) comprising an annular wall (14) featuring radial holes (15) to accommodate radially mobile balls (16), and a locking piston (20) that slides axially within the body bore between a released position and a locked position. The lock body (10) is inserted into a first hole (7) made in the surface of the first part (55) and into a second hole (8) made in the surface of the second part, the two holes being more or less coaxial.

Abstract: Method of cancer treatment by controlling cellular p53 protein levels. The invention concerns, in particular, the use of a compound capable of modulating calpaine activity.

Abstract: The ball anchoring device consists of a lock body (10) comprising an annular wall (14) featuring radial holes (15) to accommodate radially mobile balls (16), and a locking piston (20) that slides axially within the body bore between a released position and a locked position.

Abstract: The catch comprises a bolt (22) having a locking body (24) and means for clipping the body (24) into a keeper (28) by clamping the keeper (28) between a bearing bush (54) and at least one retractable locking ball (56). The bearing bush (54) is mounted to slide axially around the locking body (24), being moveable, by cooperation with the keeper (28), against a return spring force, from a position releasing the bolt (22), in which the bush (54) covers the locking ball (56), holding it in the retracted position, to a position locking the bolt (22), in which the bush (54) and the locking ball (56) grip the keeper (28). The bolt (22) further includes safety means (80) preventing accidental displacement of the bush (54) from its bolt releasing position to its bolt locking position other than by cooperation of the bush (54) with the keeper (28).

Abstract: The hinge comprises a flange (26) for connection to a seat cushion or squab, a support-flange (38) and at least one lever (34d) for coupling the flanges (26, 38) together having a first end (36A) mounted to pivot on the support-flange (38) so that the coupling lever (34d) can pivot between a position in which a second end (36B) of the lever (34d) is attached to the connecting flange (26) by virtue of cooperation of complementary shapes and a position in which the second end (36B) is released. The hinge further comprises means (100-104) for immobilising the second end (36B) of the coupling lever in the attached position, preferably comprising a weakened area (104) of the support-flange (38) that can deform when the flanges (26, 38) are subjected to an accidental torque to enable movement of the lever (34d) to the point of cooperation of ramps (100, 102) immobilising the lever (34d) in the attached position.

Abstract: The hinge includes two flanges (24, 26) adapted to be fixed to a seat cushion and a seat squab (backrest), respectively. The flanges (24, 26) can turn relative to each other about a hinge axis (X) that is substantially perpendicular to them. The hinge additionally includes a hinge control member (32) mounted to rotate about the hinge axis (X) at least one way from a rest position and means for spring loading the control member into its rest position including approximate positioning means (76) and accurate positioning means (82) for the control member (32). The accurate positioning means preferably include at least one U-shape spring (82) in axial bearing engagement between the edge of a recess (88) of a bearing (P1) supporting the control member (32) and a positioning flat (90) of the control member (32).

Abstract: An articulation has two cheeks 24, 26, intended to be fixed to a seat part and a backrest of the seat. The cheeks can rotate with respect to each other about an axis X. The articulation also includes structure 30 for coupling the cheeks together, which are actuated by two rings 42a, 42b centered substantially on the axis. The rings can be moved in two opposite directions for respectively adjusting the inclination of and for folding down the backrest, between a first position in which at least one coupling member 34a, 34b is secured to the first and to the second cheek respectively, and a second position in which the coupling member is released. The rings each comprise a stud 48a, 48b formed on their interior contour, and a spring 50 hooked onto the studs to elastically return the rings in opposite directions, into their first position.

Abstract: The seat structure comprises a frame (12) carrying a seat (14), a backrest (16) and at least one leg (20). The backrest (16) is mounted on the frame (12) to be pivotable between at least one position adapted to receive an occupant and at least one position inadapted to receive the occupant. The leg (20) is provided with a ball-type lock (28) for fixing the seat structure to a floor of the vehicle. This lock comprises a rod (32) movable between a lock locking position and a lock unlocking position. The seat (14) is connected to the backrest (16) by a mobile control linkage 46 which ensures that the position of the seat (14) is governed by the position the backrest (16). The seat structure further comprises means (58) for immobilizing the control linkage (46) when the backrest (16) is in a position inadapted to receive an occupant and the rod (32) is in an unlocking position.

Abstract: The articulation comprises two cheeks (24, 26), one of which, which is stationary, is intended to be fixed to the seat part, and the other of which, which can move, is intended to be fixed to the backrest. The cheeks (24, 26) can rotate one with respect to the other. The articulation also includes a coupling mechanism (30) for coupling the cheeks (24, 26) together, controlled by a member (32) which can be actuated in the direction for adjusting the inclination of the backrest and in the opposite direction for temporarily folding this backrest down. The coupling mechanism (30) comprise at least one lever (34a, 34b) having two ends (36A, 36B), each of which can be secured to a cheek (24, 26) by the interaction of complementary shapes (SA, SB, TA).

Abstract: The expanding and retracting ball- and broach-type lock comprises a striker plate (10), a catch bolt (20), a control device (30), an orientation device, a position detector, a safety device, a safety feature and, preferably, an ejector (80).The lock is mounted on a support (90) such as a seat subframe with a sole-plate (91) and a leg (92) which are articulated in order to rock relative to each other.Use for a removable of a "single-volume people-carrier type" vehicle seat.

Abstract: An irreversible continuous pivotal connection between a fixed part and a movable part includes a fixed side plate fixed with respect to the fixed part and having an arcuate array of teeth, as well as a movable side plate fixed with respect to the movable part and having an arcuate array of teeth. The movable side plate is mounted parallel to the fixed side plate for rotation about a fixed common axis. A planet gear is positioned between the fixed and movable side plates, and has two external arcuate arrays of teeth with different diameters and locally meshing with the arcuate arrays of teeth of the fixed and movable side plates. An eccentric member is mounted for rotation about the fixed axis and presses on the planet gear so that rotation of the eccentric member in one direction causes epicyclic rotation of the planet gear in another direction.