Patents by Inventor Jean-Marie Boeynaems

Jean-Marie Boeynaems has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibody against G-protein coupled receptor showing selective affinity for ATP and uses therefor
    Patent number: 7485703
    Abstract: The present invention relates to isolated antibodies both polyclonal and monoclonal, that specifically bind to a G-protein coupled receptor showing selective affinity for ATP. The invention further comprises a pharmaceutical composition comprising antibodies that specifically bind to the G-protein coupled receptor showing selective affinity for ATP.
    Type: Grant
    Filed: March 20, 2006
    Date of Patent: February 3, 2009
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
    Patent number: 7422846
    Abstract: The present invention is related to a method of detecting the dysregulation of GPR86 activity.
    Type: Grant
    Filed: August 31, 2005
    Date of Patent: September 9, 2008
    Assignee: Euroscreen S.A
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillian, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems
  • P2Y4 antibodies
    Patent number: 7312317
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphosphate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide.
    Type: Grant
    Filed: March 26, 2004
    Date of Patent: December 25, 2007
    Assignee: Euroscreen s.a.
    Inventors: Didier Communi, Jean-Marie Boeynaems, Marc Parmentier, Sabine Pirotton
  • G-coupled receptor showing selective affinity for ATP
    Patent number: 7288631
    Abstract: The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: October 30, 2007
    Assignee: Euroscreen, s.a.
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • Use of Atp Analogues for Treatment of Cardiovascular Diseases
    Publication number: 20070249555
    Abstract: Use of N-alkyl-2-substituted ATP analogues, pharmaceutically acceptable salts, metabolites or prodrugs thereof, for the preparation of a medicament intended to be used in the prevention and/or the treatment of cardiovascular diseases, pharmaceutical compositions comprising such compounds and a method for screening such compounds.
    Type: Application
    Filed: June 7, 2005
    Publication date: October 25, 2007
    Applicant: INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)
    Inventors: Ronald Barbaras, Bertrand Perret, Corrine Rolland, Francois Terce, Jean-Marie Boeynaems, Xavier Collet, Sebastien Jacquet, Laurent Martinez
  • Human pyrimidine receptor
    Patent number: 7270966
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent.
    Type: Grant
    Filed: January 8, 2004
    Date of Patent: September 18, 2007
    Assignee: Euroscreen SA
    Inventors: Didier Communi, Marc Parmentier, Jean-Marie Boeynaems, Sabine Pirotton
  • G-coupled receptor showing selective affinity for ATP
    Patent number: 7264940
    Abstract: The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
    Type: Grant
    Filed: October 29, 2004
    Date of Patent: September 4, 2007
    Assignee: Euroscreen, Sal
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • P2Y4 Receptor transgenic and knockout non-human mammals
    Publication number: 20070044166
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent.
    Type: Application
    Filed: July 7, 2006
    Publication date: February 22, 2007
    Inventors: Didier Communi, Sabine Pirotton, Marc Parmentier, Jean-Marie Boeynaems
  • G-coupled receptor showing selective affinity for ATP
    Publication number: 20060160149
    Abstract: The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
    Type: Application
    Filed: March 20, 2006
    Publication date: July 20, 2006
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • G-coupled receptor showing selective affinity for ATP
    Patent number: 7045345
    Abstract: The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
    Type: Grant
    Filed: May 21, 2002
    Date of Patent: May 16, 2006
    Assignee: Euroscreen, S.A.
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • Natural ligand for orphan G protein coupled receptor GPR86 and methods of use
    Publication number: 20060078918
    Abstract: The present invention is related to a method of detecting the dysregulation of GPR86 activity.
    Type: Application
    Filed: August 31, 2005
    Publication date: April 13, 2006
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillon, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems
  • Methods of identifying a ligand, an agonist, and an antagonist of G protein coupled receptor GPR86 (P2Y13)
    Patent number: 6946244
    Abstract: The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO.1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
    Type: Grant
    Filed: August 7, 2001
    Date of Patent: September 20, 2005
    Assignee: Euroscreen, S.A.
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillion, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems
  • G-coupled receptor showing selective affinity for ATP
    Publication number: 20050203282
    Abstract: The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
    Type: Application
    Filed: October 29, 2004
    Publication date: September 15, 2005
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • G-coupled receptor showing selective affinity for ATP
    Publication number: 20050158800
    Abstract: The present invention relates to an isolated G-protein coupled receptor, nucleic acid sequence encoding the receptor, and host cells capable of expressing the receptor. The invention further comprises methods for detecting the expression of a G-protein coupled receptor, and methods for identifying agonists or antagonists of the receptor. The invention still further encompasses methods for preparing an isolated G-protein coupled receptor.
    Type: Application
    Filed: October 29, 2004
    Publication date: July 21, 2005
    Inventors: Didier Communi, Jean-Marie Boeynaems
  • P2Y4 receptor transgenic and knockout non-human mammals
    Publication number: 20040268426
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent.
    Type: Application
    Filed: March 26, 2004
    Publication date: December 30, 2004
    Applicant: Euroscreen, s.a.
    Inventors: Didier Communi, Sabine Pirotton, Marc Parmentier, Jean-Marie Boeynaems
  • P2Y4 antibody and methods of use
    Publication number: 20040259171
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent.
    Type: Application
    Filed: March 26, 2004
    Publication date: December 23, 2004
    Applicant: Euroscreen, s.a.
    Inventors: Didier Communi, Sabine Pirotton, Marc Parmentier, Jean-Marie Boeynaems
  • Human pyrimidine receptor
    Patent number: 6790626
    Abstract: The present invention concerns a new receptor having a preference for pyrimidine nucleotides, preferably UTP, or purine nucleotides and UDP, and which has an amino acid sequence having more than 60% homology with the amino acid sequence shown in FIG. 1.
    Type: Grant
    Filed: November 12, 1998
    Date of Patent: September 14, 2004
    Assignee: Euroscreen S.A.
    Inventors: Didier Communi, Sabine Pirotton, Marc Parmentier, Jean-Marie Boeynaems
  • Human pyrimidine receptor
    Publication number: 20040175766
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphosphate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent.
    Type: Application
    Filed: January 8, 2004
    Publication date: September 9, 2004
    Applicant: Euroscreen, s.a.
    Inventors: Didier Communi, Sabine Pirotton, Marc Parmentier, Jean-Marie Boeynaems
  • Natural ligand of orphan G protein coupled receptor GPR86 and methods of use
    Publication number: 20040005629
    Abstract: The present invention is related to a recombinant cell expressing a nucleotide sequence encoding a G protein coupled receptor having an amino acid sequence which presents more than 70% sequence identity with SEQ ID.NO. 1 as well as to a drug screening method and kit using the orphan G protein coupled receptor GPR86, identified hereafter as receptor for ADP (P2Y13) and a homologous sequence, the corresponding polynucleotide and said recombinant cell to identify agonist, inverse agonist and antagonist compounds applicable to a diagnostic, prevention and/or treatment of various diseases and disorders.
    Type: Application
    Filed: December 3, 2002
    Publication date: January 8, 2004
    Inventors: Didier Communi, Nathalie Suarez, Michel Detheux, Stephane Brezillon, Vincent Lannoy, Marc Parmentier, Jean-Marie Boeynaems
  • HUMAN PYRIMIDINE RECEPTOR
    Publication number: 20030082674
    Abstract: This invention provides a receptor having a preference for pyrimidine nucleotides preferably uridine triphopshate over purine nucleotides. A receptor having a preference for pyrimidine nucleotides over purine nucleotides means a receptor for which pyrimidine nucleotides and purine nucleotides are not equally active and equipotent. This means that the receptor according to the invention in presence of these agonists presents a functional response (preferably the accumulation of Inositol triphosphate (IP3), diacylglycerol (DAG), or calcium ions) to lower concentration of pyrimidine nucleotides, preferably uridine triphopshate, than to purine nucleotides or a more important functional response to similar concentration of pyrimidine nucleotide than to purine nucleotide.
    Type: Application
    Filed: November 12, 1998
    Publication date: May 1, 2003
    Inventors: DIDIER COMMUNI, SABINE PIROTTON, MARC PARMENTIER, JEAN-MARIE BOEYNAEMS