Patents by Inventor Jean-Marie Grzych

Jean-Marie Grzych has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antigenic composition obtained by V8 proteolysis of a protein from S. mansoni
    Patent number: 5753236
    Abstract: An antigenic composition against S. mansoni comprising an 8 kD peptidic fragment associated with a suitable vehicle, the 8 kD peptidic fragment being obtained by controlled proteolysis using V8 protease of a 28 kD protein obtained from S. mansoni is described.
    Type: Grant
    Filed: May 10, 1995
    Date of Patent: May 19, 1998
    Assignees: Institut Pasteur, Institut Pasteur de Lille
    Inventors: Jean-Marc Balloul, Raymond Pierce, Jean-Marie Grzych, Andre Capron
  • Protein recognized by antibodies raised against native P28 of schistosoma mansoni
    Patent number: 5597570
    Abstract: The present invention relates to the development of a vaccine against schistosomiasis. It relates to a protein which includes the epitopes of the p28 protein, a poxvirus containing a gene coding for the said protein, a cell incorporating a vector for the expression of the said protein, a method for preparing the said protein, a DNA sequence coding for the p28 protein, a pharmaceutical composition, antibodies raised against the said protein and their application by way of diagnostic agents for schistosomiasis.The present invention also relates to the application of the said protein by way of an agent possessing glutathione S-transferase activity.
    Type: Grant
    Filed: October 21, 1992
    Date of Patent: January 28, 1997
    Assignee: Transgene S.A.
    Inventors: Paul Sondermeyer, Jean-Marc Balloul, Raymond Pierce, Jean-Marie Grzych, Marie-Paule Kieny, Gerard Loison, Andre Capron, Jean-Pierre Lecocq
  • Monoclonal antibodies against the 28KD protein of S. mansoni
    Patent number: 5279822
    Abstract: A hybridoma is provided which provides a monoclonal antibody of isotope IgG2a, which recognizes a strip corresponding to a peptidic fragment of 8kD, isolated by controlled proteolysis of the 28kD polypeptide of S. mansoni.
    Type: Grant
    Filed: February 19, 1992
    Date of Patent: January 18, 1994
    Assignees: Institut Pasteur, Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale
    Inventors: Jean-Marc Balloul, Raymond Pierce, Jean-Marie Grzych, Andre Capron
  • Immunogenic fraction active against bilharzioses, its preparation, and immunizing compositions containing it
    Patent number: 5021560
    Abstract: The present invention relates to an immunogenic fraction active against bilharzioses. This glycoprotein extracted from hemocyanin of a mollusc, is characterized in that its glucidic fraction represents 5 to 25% of the glycoprotein molecule and in that the molar composition of said glucidic fraction (calculated on the basis of 3 mannose residues) is substantially the following:______________________________________ Monosaccharidic residues ______________________________________ Mannose 3 Galactose 3 to 4 Fucose 2 to 3 Glucose 2 .+-. 0.2 Xylose 0.5-1 N-acetylglucosamine 3-4 N-acetylgalactosamine 2 .+-. 0.3 ______________________________________Use: immunizing compositions against bilharzioses.
    Type: Grant
    Filed: July 7, 1987
    Date of Patent: June 4, 1991
    Assignees: Institut Pasteur, Institut Pasteur de Lille, Institut National de la Sante et de la Recherche Medicale (INSERM)
    Inventors: Jean Montreuil, Genevieve Spik, Andre Capron, Colette Dissous, Jean-Marie Grzych