Patents by Inventor Jean-Marie Lehn

Jean-Marie Lehn has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • POLYVALENT DERIVATIVES OF EMOXYPINE
    Publication number: 20220096451
    Abstract: Use of polyvalent emoxypine derivatives or related compounds in the treatment or prevention of, inter alia, Parkinson's Disease are described.
    Type: Application
    Filed: February 7, 2020
    Publication date: March 31, 2022
    Inventors: Claude NICOLAU, Jean-Marie LEHN, Renald THINARD, Youssef ATOINI
  • INOSITOL-BASED IMMUNOTHERAPIES
    Publication number: 20210361680
    Abstract: The present invention provides, inter alia, methods and compositions that are useful in the treatment of cancer.
    Type: Application
    Filed: May 3, 2019
    Publication date: November 25, 2021
    Inventors: Claude NICOLAU, Claudine KIEDA, Jean-Marie LEHN
  • TUMOR ERADICATION BY INOSITOL-TRIPYROPHOSPHATE
    Publication number: 20170027966
    Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
    Type: Application
    Filed: August 4, 2016
    Publication date: February 2, 2017
    Inventors: Claude Nicolau, Jean-Marie Lehn
  • METHOD OF REDUCING MULTI-DRUG RESISTANCE USING INOSITOL TRIPYROPHOSPHATE
    Publication number: 20160235771
    Abstract: Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be used to reduce the amount of a second chemotherapeutic drug required for anticancer activity. In addition, ITPP enhances immune response and treats hyperproliferative disorders.
    Type: Application
    Filed: May 3, 2016
    Publication date: August 18, 2016
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Claudine Kieda
  • TUMOR ERADICATION BY INOSITOL-TRIPYROPHOSPHATE
    Publication number: 20160120887
    Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
    Type: Application
    Filed: December 13, 2013
    Publication date: May 5, 2016
    Applicant: NormOxys, Inc.
    Inventors: Claude Nicolau, Jean-Marie Lehn
  • MYO-INOSITOL TRISPYROPHOSPHATE AS AN ANTI-OBESITY AGENT
    Publication number: 20160067267
    Abstract: The present invention provides for novel treatments of obesity and overweight and related disorders. The invention provides, in part, method of treatment comprising, or uses of inositol-tripyrophosphate (ITPP) in these disease states.
    Type: Application
    Filed: March 14, 2014
    Publication date: March 10, 2016
    Applicant: NormOxys, Inc.
    Inventors: Ruth Greferath, Jean-Marie Lehn, Yves Claude Nicolau
  • BRANCHED OR MACROCYCLIC POLYAMINES AND USES THEREOF
    Publication number: 20150239824
    Abstract: The present invention relates to synthetic polyamines and their polyammonium derivatives and their use as a pharmacological or biological research tool or as a therapeutic agent.
    Type: Application
    Filed: August 23, 2013
    Publication date: August 27, 2015
    Inventors: Marie-France Carlier, Girish Kumar Koripelly, Jean-Marie Lehn, Iliana Nedeva, Daniel Riveline
  • Inositol pyrophosphates, and methods of use thereof
    Patent number: 9078908
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Grant
    Filed: June 20, 2013
    Date of Patent: July 14, 2015
    Assignee: NormOxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • METHOD OF REDUCING MULTI-DRUG RESISTANCE USING INOSITOL TRIPYROPHOSPHATE
    Publication number: 20140199261
    Abstract: Inositol trisphosphate (ITPP) causes normalization of tumor vasculature and is a particularly effective cancer therapy when a second chemotherapeutic agent is administered following partial vascularization. ITPP also treats, alone or in combination, multi-drug resistant cancers. ITPP can also be used to reduce the amount of a second chemotherapeutic drug required for anticancer activity. In addition, ITPP enhances immune response and treats hyperproliferative disorders.
    Type: Application
    Filed: July 25, 2013
    Publication date: July 17, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Claudine Kieda
  • CALCIUM/SODIUM SALT OF INOSITOL TRIPYROPHOSPHATE AS AN ALLOSTERIC EFFECTOR OF HEMOGLOBIN
    Publication number: 20140194391
    Abstract: The present invention relates to mixed calcium/sodium salt of inositol tripyrophosphate, methods of preparing and methods of use. The mixed calcium/sodium salt may be a monocalcium tetrasodium salt of inositol tripyrophosphate. Methods of use include administering the above salts in an effective amount to treat diseases caused by hypoxia or other conditions associated with inadequate function of the lungs or circulatory system, such as various types of cancer and Alzheimer's disease.
    Type: Application
    Filed: November 8, 2013
    Publication date: July 10, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • TUMOR ERADICATION BY INOSITOL-TRIPYROPHOSPHATE
    Publication number: 20140179635
    Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
    Type: Application
    Filed: December 13, 2013
    Publication date: June 26, 2014
    Applicant: NormOxys, Inc.
    Inventors: Claude Nicolau, Jean-Marie Lehn
  • INOSITOL PYROPHOSPHATES, AND METHODS OF USE THEREOF
    Publication number: 20140170127
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphospahte (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Application
    Filed: June 20, 2013
    Publication date: June 19, 2014
    Inventors: Yves Claude NICOLAU, Jean-Marie LEHN, Konstantina C. FYLAKTAKIDOU, Ruth GREFERATH
  • CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20140171394
    Abstract: The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
    Type: Application
    Filed: December 9, 2013
    Publication date: June 19, 2014
    Applicants: Universite de Strasbourg, NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
  • POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES
    Publication number: 20140155334
    Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
    Type: Application
    Filed: November 25, 2013
    Publication date: June 5, 2014
    Applicants: Université de Strasbourg, NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
  • PHOSPHORYLATED POLYOLS, PYROPHOSPHATES, AND DERIVATIVES THEREOF HAVING BIOLOGICAL ACTIVITY
    Publication number: 20140142052
    Abstract: The present invention provides phosphorylated and pyrophosphate derivatives of polyols, and structural derivatives of these compounds, and provides pharmaceutical compositions comprising the same. The compounds and compositions disclosed herein have various biological activities, including for example, as allosteric effectors of hemoglobin and/or as kinase inhibitors. The present invention further provides methods for therapy in human or mammalian patients, and methods for synthesis of biologically active compounds and their intermediates.
    Type: Application
    Filed: May 17, 2013
    Publication date: May 22, 2014
    Applicant: NormOxys, Inc.
    Inventors: Jean-Marie Lehn, Yves Claude Nicolau, Srinivasu Pothukanuri, Adam Brockman, John Hey, Jeremy Yu
  • POLYPHOSPHATE AND PYROPHOSPHATE DERIVATIVE OF SACCHARIDES
    Publication number: 20140088036
    Abstract: The present invention provides, among other things, phosphorylated and pyrophosphate derivatives of mono-, di- and oligosaccharides, as well as structural derivatives of these compounds. These compounds have a variety of uses including for pharmaceutical applications. Also provided are methods of use in the treatment of disease, including diseases related to oxygen delivery.
    Type: Application
    Filed: September 30, 2011
    Publication date: March 27, 2014
    Applicants: UNIVERSITE DE STRASBOURG, NORMOXYS, INC.
    Inventors: Jean Marie Lehn, Yves Claude Nicolau, Rajamalleswaramma Jogireddy, Adam H. Brockman, John Hey, Yongxin Yu
  • CYCLITOLS AND THEIR DERIVATIVES AND THEIR THERAPEUTIC APPLICATIONS
    Publication number: 20130190524
    Abstract: The present invention is directed to polyphosphorylated and pyrophosphate derivatives of cyclitols. More particularly, the invention relates to polyphosphorylated and pyrophosphate derivatives of inositols. The invention also relates to compositions of the polyphosphorylated and pyrophosphate derivatives of inositol and other similar, more lipophilic derivatives, and their use as allosteric effectors, cell-signaling molecule analogs, and therapeutic agents.
    Type: Application
    Filed: August 22, 2012
    Publication date: July 25, 2013
    Applicants: UNIVERSITE DE STRASBOURG, NORMOXYS, INC.
    Inventors: Jean-Marie Lehn, Srinivasu Pothukanuri, Alexandros Koumbis, Carolina Duarte, Claude Nicolau
  • INOSITOL PYROPHOSPHATES, AND METHODS OF USE THEREOF
    Publication number: 20130059820
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Application
    Filed: March 21, 2012
    Publication date: March 7, 2013
    Applicant: NORMOXYS, INC.
    Inventors: Yves Claude NICOLAU, Jean-Marie LEHN, Konstantina FYLAKTAKIDOU, Ruth GREFERATH
  • Inositol pyrophosphates, and methods of use thereof
    Patent number: 8178514
    Abstract: The present invention comprises compounds, compositions thereof, and methods capable of delivering modified inositol hexaphosphate (IHP) comprising an internal pyrophosphate ring to the cytoplasm of mammalian cells. In certain embodiments, the present invention relates to compounds, compositions thereof, and methods that enhance the ability of mammalian red blood cells to deliver oxygen, by delivering IHP to the cytoplasm of the red blood cells.
    Type: Grant
    Filed: February 10, 2011
    Date of Patent: May 15, 2012
    Assignee: Normoxys, Inc.
    Inventors: Yves Claude Nicolau, Jean-Marie Lehn, Konstantina C. Fylaktakidou, Ruth Greferath
  • TUMOR ERADICATION BY INOSITOL-TRIPYROPHOSPHATE
    Publication number: 20120094961
    Abstract: The present invention relates to various salts of inositol tripyrophosphate including the calcium, lithium, beryllium, magnesium, potassium, strontium, barium, rubidium and cesium salts of inositol tripyrophosphate, compositions comprising these salts, methods of making the various salts, and methods of use of the above salts. Methods of use include administering the above salts in an effective amount in individuals for the treatment of various types of cancers, Alzheimer's disease, stroke and osteoporosis.
    Type: Application
    Filed: September 28, 2011
    Publication date: April 19, 2012
    Applicant: Normoxys, Inc.
    Inventors: Claude NICOLAU, Jean-Marie Lehn