Abstract: This disclosure relates to methods of using 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide in a disease modifying therapy of Alzheimer's disease, other tauopathies and related neurodegenerative diseases.

Abstract: This disclosure relates to methods of using 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide in a disease modifying therapy of Alzheimer's disease, other tauopathies and related neurodegenerative diseases.

Abstract: This disclosure relates to methods of using 2-(cyclohexylmethyl)-N-{2-[(2S)-1-methylpyrrolidin-2-yl]ethyl}-1,2,3,4-tetrahydroisoquinoline-7-sulfonamide in a disease modifying therapy of Alzheimer's disease, other tauopathies and related neurodegenerative diseases.

Abstract: A centrifugal pump, of the type comprising a body, a shaft rotatable in the body via a bearing, an impeller fixed on the shaft and, between the impeller and the bearing, a mechanical seal assembly comprising a pair of engaging slide rings and an inner sleeve made of elastomeric material, fitted on the shaft, the said sleeve comprising a portion adjacent the impeller on which is fixed one of the slide rings and, at the end on the bearing side, a radial flare for holding the seal assembly in the assembled state prior to its mounting, said sleeve being extended axially, beyond said radial flare, by a lip member arranged to rub on the adjacent surface of the bearing.

Abstract: An odometer for displaying the speed of a vehicle and the distance travelled, comprising an input shaft driven at a speed proportional to that of the vehicle, a speedometer unit connected to the input shaft, a mileage recording unit comprising a plurality of graduated drums mounted side by side on a common shaft and driven from the input shaft, a plurality of radially projecting stop lugs, and a frame for supporting said unit in rotation, the frame comprising two parallel walls provided with recesses for receiving the respective ends of the shaft of the mileage recording unit.The frame comprises a bar extending between said walls parallel to said common shaft and providing stop means for the projecting stop lugs. There is associated with the bar a locking element for immobilizing the stop lugs in their stop position, which element is force-fitted in recesses formed in the walls of the frame substantially in the plane of the bar.

Abstract: A fluid seal assembly to be mounted between a fixed part and a rotary shaft, comprising a slide ring secured to a resilient sealing member attached to the shaft and urged by a spring into engagement with a counter-ring secured to the fixed part, said slide ring having an axial extension embracing the resilient sealing member, wherein the slide ring has a smooth external surface which tapers inwardly in the direction remote from the sliding surface thereof.

Abstract: A centrifugal pump comprising a housing, a shaft rotatably mounted in a bore of the housing, a wheel fixed to a hub secured to the shaft and comprising a plurality of angularly distributed openings, a seal assembly comprising a counter-ring, a friction ring secured to a flexible member and resilient means for urging the ring into contact with the counter-ring, the counter-ring and flexible member being secured to respective connection members, of which one is fitted in a recess of the housing and comprises a radial thrust surface facing said openings of the wheel while the other is fixed to the hub and is made of elastomer material, further comprising a sleeve surrounding the shaft, said sleeve being secured to the hub at one end thereof and being provided at its other end with a radially enlarged abutment portion to retain said one connection member or the respective one of said counter-ring and said flexible member before its mounting inside said housing.