Patents by Inventor Jean-Michel Bonard

Jean-Michel Bonard has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • 1-[2-(4-benzyl-4-hydroxy-piperidin-1 -yl )-ethyl]-3-(2-methyl-quinolin- 4-yl)- urea as crystalline sulfate salt
    Patent number: 8067601
    Abstract: The invention relates to 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt and a process for its preparation. Further, the present invention relates to the use of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt alone or in combination with other compounds. Further, the present invention relates to formulations of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt in the preparation of pharmaceutical compositions. The invention also relates to the use of such sulfate salts in formulations as neurohormonal antagonists.
    Type: Grant
    Filed: October 11, 2005
    Date of Patent: November 29, 2011
    Assignee: Actelion Pharmaceticals Ltd.
    Inventors: Jean-Michel Bonard, Stephan Buchmann, Stéphane Redey, Bertrand Woinet
  • 1-[2-(4-BENZYL-4-HYDROXY-PIPERIDIN-1 -YL )-ETHYL]-3-(2-METHYL-QUINOLIN- 4-YL)- UREA AS CRYSTALLINE SULFATE SALT
    Publication number: 20090023775
    Abstract: The invention relates to 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt and a process for its preparation. Further, the present invention relates to the use of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt alone or in combination with other compounds. Further, the present invention relates to formulations of said 1-[2-(4-benzyl-4-hydroxy-piperidin-1-yl)-ethyl]-3-(2-methyl-quinolin-4-yl)-urea as a crystalline, stoichiometrically defined and non-hygroscopic sulfate salt in the preparation of pharmaceutical compositions. The invention also relates to the use of such sulfate salts in formulations as neurohormonal antagonists.
    Type: Application
    Filed: October 11, 2005
    Publication date: January 22, 2009
    Applicant: Actelion Pharmaceuticals Ltd.
    Inventors: Jean-Michel Bonard, Stephan Buchmann, Stephane Redey, Bertrand Woinet
  • Polymorphic B form of 3-(cyclopropylmethoxy)-4-[4-(methylsulfonyl)phenyl]-5,5-dimethyl-5H-furan-2-one
    Patent number: 6677373
    Abstract: This invention is related to a polymorphic B Form of 3-(cyclopropylmethoxy)-4-[4-(methylsulfonyl)phenyl]-5,5-dimethyl-5H-furan-2-one characterized by the following parameters: cristalline system Trigonal space group R-3 description hexagonal unit-cell dimensions a (Å) 18.183 b (Å) 18.183 c (Å) 26.950 &agr; (°) 90 &bgr; (°) 90 &ggr; (°) 120 unit-cell volume (Å3) 7716.5 number of molecules per unit-cell Z 18 Temperature of measurement (° K) 293 calculated specific gravity 1.303 weight absorption coefficient (cm−1) 2.11.
    Type: Grant
    Filed: April 8, 2002
    Date of Patent: January 13, 2004
    Assignee: Merial Limited
    Inventors: Beatrice Calais, Evelyne Chassagneux, Jean-Michel Bonard
  • Polymorphic B Form of 3-(cyclopropylmethoxy)-4-[4(methylsulfonyl)phenyl]-5,5- dimethyl-5H-furan-2-one
    Publication number: 20030050337
    Abstract: This invention is related to a polymorphic B Form of 3-(cyclopropylmethoxy)-4-[4-(methylsulfonyl)phenyl]-5,5-dimethyl-5H-furan-2-one characterized by the following parameters: 1 cristalline system Trigonal space group R-3 description hexagonal unit-cell dimensions a (Å) 18.183 b (Å) 18.183 c (Å) 26.950 &agr; (°) 90 &bgr; (°) 90 &ggr; (°) 120 unit-cell volume (Å3) 7716.5 number of molecules per unit-cell Z 18 Temperature of measurement (° K) 293 calculated specific gravity 1.303 weight absorption coefficient (cm−1) 2.
    Type: Application
    Filed: April 8, 2002
    Publication date: March 13, 2003
    Inventors: Beatrice Calais, Evelyne Chassagneux, Jean-Michel Bonard