Patents by Inventor Jean-Michel Bouler
Jean-Michel Bouler has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
-
Publication number: 20220323639Abstract: A bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood is disclosed. A method for preparation of the phosphocalcic cement composition is also disclosed.Type: ApplicationFiled: June 21, 2022Publication date: October 13, 2022Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, ONIRIS, GRAFTYSInventors: Jean-Michel BOULER, Olivier GAUTHIER, Bruno BUJOLI, Pascal JANVIER, Charlotte MELLIER
-
Publication number: 20220273841Abstract: A bone cement composition including a powder component, a liquid component, and hyaluronic acid (HA) or a salt thereof in an amount ranging from 0.01% to 10% w/w in the powder component and/or in the liquid component. The powder component includes calcium phosphate compounds having at least alpha-tricalcium phosphate (?-TCP) and having at least calcium-deficient apatite (CDA). Also, a bone cement obtainable by a process including the following steps: (i) the preparation of a cement composition by mixing the powder component, and the liquid component and (ii) the setting of the cement composition. Further, the use in vitro or ex vivo of a bone cement composition or bone cement in the manufacture of a dental or bony implant.Type: ApplicationFiled: July 17, 2020Publication date: September 1, 2022Applicants: GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUEInventors: Enrico Javier BASTIANELLI, Jean-Michel BOULER, Bruno BUJOLI
-
Patent number: 11395862Abstract: A bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood is disclosed. A method for preparation of the phosphocalcic cement composition is also disclosed.Type: GrantFiled: April 6, 2017Date of Patent: July 26, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, ONIRIS, GRAFTYSInventors: Jean-Michel Bouler, Olivier Gauthier, Bruno Bujoli, Pascal Janvier, Charlotte Mellier
-
Patent number: 11338054Abstract: A method for promoting spine fusion inside intersomatic cages, comprising placing a fusion cage between two vertebral bodies, and injecting a bone cement paste inside said fusion cage, said bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood.Type: GrantFiled: August 14, 2019Date of Patent: May 24, 2022Assignees: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITE DE NANTES, ONIRIS, GRAFTYSInventors: Jean-Michel Bouler, Olivier Gauthier, Bruno Bujoli, Pascal Janvier, Charlotte Mellier
-
Publication number: 20190365945Abstract: A method for promoting spine fusion inside intersomatic cages, comprising placing a fusion cage between two vertebral bodies, and injecting a bone cement paste inside said fusion cage, said bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood.Type: ApplicationFiled: August 14, 2019Publication date: December 5, 2019Inventors: Jean-Michel Bouler, Olivier Gauthier, Bruno Bujoli, Pascal Janvier, Charlotte Mellier
-
Publication number: 20190134261Abstract: A bone cement paste containing a powder component comprising ?-tricalcium phosphate (?-TCP) particles having an average size greater than or equal to 9 ?m, and a liquid component comprising blood is disclosed. A method for preparation of the phosphocalcic cement composition is also disclosed.Type: ApplicationFiled: April 6, 2017Publication date: May 9, 2019Inventors: Jean-Michel Bouler, Olivier Gauthier, Bruno Bujoli, Pascal Janvier, Charlotte Mellier
-
Patent number: 9913928Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: GrantFiled: November 14, 2014Date of Patent: March 13, 2018Assignees: GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)Inventors: Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
-
Patent number: 9642939Abstract: The present invention is directed to a novel cement powder comprising an organic component consisting of one or more biocompatible and bioresorbable polymers and an inorganic component consisting of one or more calcium phosphate compounds. The invention also relates to the apatitic CPC resulting from the mixing of said cement powder with a liquid phase and setting.Type: GrantFiled: August 23, 2007Date of Patent: May 9, 2017Assignees: GRAFTYS, UNIVERSITE DE NANTESInventors: Ibrahim Khairoun, Pierre Weiss, Jean-Michel Bouler
-
Publication number: 20150140118Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: ApplicationFiled: November 14, 2014Publication date: May 21, 2015Inventors: Jean-Michel BOULER, Bruno BUJOLI, Pascal JANVIER, Ibrahim KHAIROUN, Jean-Noël ARGENSON
-
Patent number: 8920555Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: GrantFiled: December 2, 2013Date of Patent: December 30, 2014Assignees: Graftys SA, University de Nantes, Centre National de la Recherche ScientifiqueInventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
-
Patent number: 8894958Abstract: The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.Type: GrantFiled: March 3, 2010Date of Patent: November 25, 2014Assignees: Centre National de la Recherche Scientifique (C.N.R.S.), University de Nantes, GraftysInventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler, Charlotte Mellier
-
Patent number: 8889165Abstract: The present invention relates to a macroporous, resorbable and injectable apatitic calcium-phosphate cement with a high compressive strength useful as bone cement and releasing a bone resorption inhibitor, preparation method and uses thereof.Type: GrantFiled: February 14, 2008Date of Patent: November 18, 2014Assignees: Graftys, Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Jean-Michel Bouler, Bruno Bujoli, Pascal Janvier, Ibrahim Khairoun, Jean-Noël Argenson
-
Publication number: 20140087004Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5?1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: ApplicationFiled: December 2, 2013Publication date: March 27, 2014Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
-
Patent number: 8623311Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: GrantFiled: March 3, 2010Date of Patent: January 7, 2014Assignees: Graftys, Universite de Nantes, Centre National de la Recherche Scientifique (C.N.R.S.)Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
-
Publication number: 20140004207Abstract: The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.Type: ApplicationFiled: September 3, 2013Publication date: January 2, 2014Applicants: Graftys, Ecole Nationale Veterinaire de Nantes, Universite de NantesInventors: Hervé Leguen, Rémi Cavagna, Ibrahim Khairoun, Elise Verron, Pascal Janvier, Olivier Gauthier, Jean-Michel Bouler
-
Publication number: 20120111226Abstract: The present invention relates to a galliated calcium-phosphate biomaterial comprising a gallium-doped phosphocalcic compound of formula (I): Ca(005-1 5X)Gax(PO—O4)7, wherein 0<x<1 and the salts, hydrates and mixtures thereof and/or a calcium deficient apatite structure with in particular a (Ca+Ga)/P molar ratio in the range of 1.3 to 1.67, and a gallium content up to 4.5% by weight. It also relates to processes of preparation of such materials and uses thereof, in particular as dental or bony implants. It further relates to a kit comprising a galliated calcium-phosphate biomaterial in combination with a fluid component. It finally relates to methods of use of the galliated calcium-phosphate biomaterial, notably for III) ions increase radio-opacity after bone implantation and can be released for inhibiting bone resorption.Type: ApplicationFiled: March 3, 2010Publication date: May 10, 2012Applicants: GRAFTYS, UNIVERSITE DE NANTES, CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S)Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler, Charlotte Mellier
-
Publication number: 20120064170Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7, wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: ApplicationFiled: March 3, 2010Publication date: March 15, 2012Applicants: UNIVERSITE DE NANTES, GRAFTYSInventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler
-
Patent number: 8044037Abstract: A phosphocalcic compound modified by a gem-bisphosphonic acid or one of its salts, a method for preparing same, as well as its use for preparing an injectable composition. The modified phosphocalcic compound is obtained by adding a gem-bisphosphonic acid or one of its alkali metal or alkaline earth salts to a suspension of a precursor phosphocalcic compound in ultras-pure water, while stirring the reaction medium at room temperature, then in recovering by centrifuging the formed compound. The compound is useful for making an injectable composition, for use in the treatment of bone remodeling equilibrium.Type: GrantFiled: April 14, 2009Date of Patent: October 25, 2011Assignees: Centre National de la Recherche Scientifique, Université de Nantes, Institut National de la Santé et de la Recherche MédicaleInventors: Bruno Bujoli, Solen Josse, Jérôme Guicheux, Pascal Janvier, Jean-Michel Bouler, Guy Daculsi
-
Publication number: 20110142940Abstract: The present invention concerns a composition useful as bone substitute comprising one or more calcium-phosphate compounds in association with an analgesic. It also refers to a preparation process of said composition, a preparation process of a drug-combined device comprising said composition, the drug combined device thus obtained, a kit comprising said composition and the use of said composition for the preparation of a drug-combined device useful for filling a bony defect caused in the iliac crest by collection of auto-graft bone, as a scaffold for tissue engineering and to produce a dental or bony implant.Type: ApplicationFiled: January 6, 2009Publication date: June 16, 2011Applicants: GRAFTYS, UNIVERSITE DE NANTES, ECOLE NATIONALE VETERINAIRE DE NANTESInventors: Hervé Leguen, Rémi Cavagna, Ibrahim Khairoun, Elise Verron, Pascal Janvier, Olivier Gauthier, Jean-Michel Bouler
-
Publication number: 20100269734Abstract: The present invention relates to a gallium-doped phosphocalcic compound of formula (I): Ca(10.5-1.5x)Gax(PO4)7??(I) wherein 0<x<1 and the salts, hydrates and mixtures thereof. The invention further relates to a solid state process and a process in solution for the manufacture of such compounds and the use thereof for the preparation of a biomaterial, in particular a self-setting calcium-phosphate cement (CPC).Type: ApplicationFiled: March 3, 2010Publication date: October 28, 2010Inventors: Bruno Bujoli, Jean-Michel Bouler, Pascal Janvier, Ibrahim Khairoun, Verena Schnitzler