Patents by Inventor Jean-Michel Culouscou

Jean-Michel Culouscou has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Antibodies to HER4, human receptor tyrosine kinase
    Patent number: 5811098
    Abstract: The molecular cloning, expression, and biological characteristics of a novel receptor tyrosine kinase related to the epidermal growth factor receptor, termed HER4/p180.sup.erbB4, are described. Antibodies to HER4 are disclosed. A HER4 ligand capable of inducing cellular differentiation of breast cancer cells is also disclosed. In view of the expression of HER4 in several human cancers and in certain tissues of neuronal and muscular origin, various diagnostic and therapeutic uses of HER4-derived and HER4-related biological compositions are provided.
    Type: Grant
    Filed: June 7, 1995
    Date of Patent: September 22, 1998
    Assignee: Bristol-Myers Squibb Company
    Inventors: Gregory D. Plowman, Jean-Michel Culouscou, Mohammed Shoyab, Clay B. Siegall, Ingegerd Hellstrom, Karl E. Hellstrom