Patents by Inventor Jean-Michel LeFrancois

Jean-Michel LeFrancois has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Imidazolidine compounds as androgen receptor modulators
    Patent number: 7968581
    Abstract: Novel compounds are disclosed that have a Formula represented by the following: wherein X, R1, R2a, R2b, R2c, R3a R3b, R4a, R4b, R4c, and m1 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cachexia, osteoporosis, sarcopenia, a decline in libido and/or sexual dysfunction.
    Type: Grant
    Filed: September 10, 2009
    Date of Patent: June 28, 2011
    Assignee: Galapagos NV
    Inventors: François Nique, Catherine Jagerschmidt, Florence Sylvie Namour, Roland Blanqué, Jean-Michel Lefrançois, Christophe Peixoto, Pierre Deprez, Nicolas Triballeau, Piet Tom Bert Paul Wigerinck
  • PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONIST OF THE VITRONECTIN RECEPTOR
    Publication number: 20110039867
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: October 25, 2010
    Publication date: February 17, 2011
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Methods for the use of pyrimidine derivatives which are antagonists of vitronectin receptor
    Patent number: 7846932
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: August 14, 2009
    Date of Patent: December 7, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Pyrimidine derivatives which are antagonists of vitronectin receptor
    Patent number: 7825119
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 13, 2005
    Date of Patent: November 2, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
    Patent number: 7763621
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: October 3, 2008
    Date of Patent: July 27, 2010
    Assignee: Galapagos SAS
    Inventors: Jean-Marie Ruxer, Jean-Michel Lefrancois, Bertrand Heckmann
  • NOVEL IMIDAZOLIDINE COMPOUNDS AS ANDROGEN RECEPTOR MODULATORS
    Publication number: 20100113547
    Abstract: Novel compounds are disclosed that have a Formula represented by the following: wherein X, R1, R2a, R2b, R2c, R3a R3b, R4a, R4b, R4c, and m1 are as described herein. The compounds may be prepared as pharmaceutical compositions, and may be used for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, cachexia, osteoporosis, sarcopenia, a decline in libido and/or sexual dysfunction.
    Type: Application
    Filed: September 10, 2009
    Publication date: May 6, 2010
    Inventors: François Nique, Catherine Jagerschmidt, Florence Sylvie Namour, Roland Blanqué, Jean-Michel Lefrançois, Christophe Peixoto, Pierre Deprez, Nicolas Triballeau, Piet Tom Bert Paul Wigerinck
  • METHODS FOR THE USE OF PYRIMIDINE DERIVATIVES WHICH ARE ANTAGONISTS OF VITRONECTIN RECEPTOR
    Publication number: 20100041675
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: August 14, 2009
    Publication date: February 18, 2010
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
    Patent number: 7582640
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Grant
    Filed: November 12, 2003
    Date of Patent: September 1, 2009
    Assignee: Galapagos SAS
    Inventors: Jean-Marie Ruxer, Jean-Michel Lefrancois, Bertrand Heckmann
  • Novel vitronectin receptor antagonist derivatives, method for preparing same, use thereof as medicines and pharmaceutical compositions containing same
    Publication number: 20090149476
    Abstract: A subject of the invention is the compounds of formula (I): in which R1, R2, R3, R4 and G have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: October 3, 2008
    Publication date: June 11, 2009
    Inventors: Jean-Marie Ruxer, Jean Michel Lefrancois, Bertrand Heckmann
  • Pyrimidine Derivatives Which Are Antagonists Of Vitronectin Receptor
    Publication number: 20080058348
    Abstract: A subject of the invention is the compounds of formula (I); in which R1, R2, R3, R4 and R have the meanings indicated in the description, their preparation process, their use as medicaments having an antagonist activity on the vitronectin receptor and the pharmaceutical compositions containing them.
    Type: Application
    Filed: May 13, 2005
    Publication date: March 6, 2008
    Inventors: Jean-Michel Lefrancois, Bertrand Heckmann
  • Vitronectin receptor antagonists, their preparation and their use
    Patent number: 6867208
    Abstract: The present invention relates to compounds of the formula I A—B—D—E—F—G??(I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: May 13, 2002
    Date of Patent: March 15, 2005
    Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Antagonist derivatives of the vitronectin receptor
    Patent number: 6838453
    Abstract: The invention concerns vitronectin receptor antagonist compounds of formula (3): R1—Y—A—B—D—E—F—G wherein R1, Y, A, B, D, E, F, and G are as defined in the description, their physiologically acceptable salts and their prodrugs, methods for preparing compounds of formula (I), their use, in particular as medicine and pharmaceutical compositions containing them.
    Type: Grant
    Filed: May 4, 2001
    Date of Patent: January 4, 2005
    Assignee: Aventis Pharma S.A.
    Inventors: Jacques Demassey, Jean-Francois Gourvest, Jean-Marie Ruxer, John Bernard Weston, Jean-Michel LeFrancois
  • ANTAGONIST DERIVATIVES OF THE VITRONECTIN RECEPTOR
    Publication number: 20040225111
    Abstract: The invention concerns vitronectin receptor antagonist compounds of formula (I): R1—Y-A-B-D-E-F-G wherein R1, Y, A, B, D, E, F, and G are as defined in the description, their physiologically acceptable salts and their prodrugs, methods for preparing compounds of formula (I), their use, in particular as medicine and pharmaceutical compositions containing them.
    Type: Application
    Filed: November 4, 2002
    Publication date: November 11, 2004
    Inventors: Jacques Demassey, Jean-Francois Gourvest, Jean-Marie Ruxer, John Bernard Weston, Jean-Michel LeFrancois
  • Vitronectin receptor antagonists, their preparation and use
    Publication number: 20030119785
    Abstract: The present invention relates to compounds of the formula I,
    Type: Application
    Filed: November 19, 2002
    Publication date: June 26, 2003
    Applicant: Hoechst Aktiengesellschaft and Genentech Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Karlheinz Scheunemann, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Vitronectin receptor antagonists, their preparation and their use
    Publication number: 20030027807
    Abstract: The present invention relates to compounds of the formula I
    Type: Application
    Filed: May 13, 2002
    Publication date: February 6, 2003
    Applicant: Genentech, Inc. and Hoechst Aktiengesellschaft
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Vitronectin receptor antagonists, their preparation and their use
    Patent number: 6482821
    Abstract: Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I, A—B—D—E—F—G   (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: February 8, 2001
    Date of Patent: November 19, 2002
    Assignees: Hoechst Aktiengellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Karlheinz Scheunemann, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Vitronectin receptor antagonists, their preparation and their use
    Patent number: 6387895
    Abstract: The present invention relates to compounds of the formula I A—B—D—E—F—G  (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: February 6, 2001
    Date of Patent: May 14, 2002
    Assignees: Hoechst Aktiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Vitronectin receptor antagonists, their preparation and their use
    Publication number: 20010011087
    Abstract: Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula 1,
    Type: Application
    Filed: February 8, 2001
    Publication date: August 2, 2001
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Karlheinz Scheunemann, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Vitronectin receptor anatagonists, their preparation and their use
    Patent number: 6218387
    Abstract: The present invention relates to compounds of the formula I, A—B—D—E—F—G  (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: April 17, 2001
    Assignees: Hoechst Aktiengesellschaft, Genetech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Karlheinz Scheunemann, Jean-Marie Ruxer, Denis Carniato, Jean-Michel Lefrancois, Thomas Richard Gadek, Robert McDowell
  • Vitronectin receptor antagonists, their preparation and use
    Patent number: 6207663
    Abstract: Vitronectin receptor antagonists, their preparation and their use The present invention relates to compounds of the formula I A—B—D—E—F—G   (I) in which A, B, D, E, F and G have the meanings given in the patent claims, to their preparation and to their use as medicaments. The compounds of the invention are used as vitronectin receptor antagonists and as inhibitors of bone resorption.
    Type: Grant
    Filed: October 5, 1999
    Date of Patent: March 27, 2001
    Assignees: Hoechst Atkiengesellschaft, Genentech, Inc.
    Inventors: Volkmar Wehner, Hans Ulrich Stilz, Anuschirwan Peyman, Jochen Knolle, Jean-Marie Ruxer, Denis Carniato, Jean-Michel LeFrancois, Thomas Richard Gadek, Robert McDowell