Abstract: Disclosed is a misuse preventative, controlled release formulation comprising a core comprising a superabsorbent material (for example, polycarbophil), a controlled release coat surrounding the core, and a plurality of controlled release microparticles having a pharmaceutically active agent (for example, an opioid analgesic) disposed within the core, the coat, or both the core and the coat. When crushed, either intentionally or accidentally, and exposed to an aqueous medium, the superabsorbent material present in the core swells to encapsulate the microparticles, which remain substantially intact thereby retarding the release of the pharmaceutically active agent from the formulation. Also disclosed is a method of using the misuse preventative, controlled release formulation to deliver a pharmaceutically active agent to a mammal, for example, a human, in need thereof.

Abstract: The invention relates to any electronic device such as a chip card, a passport, a dongle or any other object requiring personalization of the content of a memory. More precisely, the invention provides for a method for processing a data item of a container stored in a memory, said method being implemented by the electronic device by utilizing in particular a table of identifiers. The invention furthermore provides for a prior step for associating a data identifier with a data item of a container and creating said table of identifiers.

Abstract: A light emitting device includes a semiconductor nanocrystal and a charge transporting layer that includes an inorganic material. The charge transporting layer can be a hole or electron transporting layer. The inorganic material can be an inorganic semiconductor.

Abstract: At least one microneedle comprises a hydrogel material that includes a substance that fluoresces when the substance interacts with an analyte. A magnitude of the fluorescence varies as a function of the concentration of the analyte. During use, the hydrogel material is illuminated with illumination light in a first wavelength range while the hydrogel material interfaces with the dermal interstitial fluid layer of a subject, and a photosensor generates an output that corresponds to an amount of light received in a second wavelength range.

Abstract: A database server receives a request from a client application for performing a data transaction on persistent data storage. The request is sent to a set of replication servers. An acknowledgement for the request is received from each replication server, including a start sequence number and an end sequence number for data that is stored in local cache of the replication server, and a latest committed sequence number for data that was written to the persistent data storage by the replication server. A maximum value of latest committed sequence numbers received from the set of replication servers is determined. For each replication server, it is examined whether there is a gap between the start sequence number for data stored in local cache and the maximum value of the latest committed sequence numbers. Based on the examining, it is determined whether there is an occurrence of loss of data.

Abstract: This application discloses anti-P-cadherin antibodies, antigen binding fragments thereof, and antibody drug conjugates of said antibodies or antigen binding fragments. The invention also relates to methods of treating cancer using the antibodies, antigen binding fragments, and antibody drug conjugates. Also disclosed herein are methods of making the antibodies, antigen binding fragments, and antibody drug conjugates, and methods of using the antibodies and antigen binding fragments as diagnostic reagents.

Abstract: The system for rapidly reactivating a turbine engine of an aircraft includes an electrical machine that is DC powered from an on-board electrical power supply network. The system also includes a switch interposed between the on-board network and the electrical machine, an additional set including a plurality N electrical energy storage elements, and a control unit for controlling a device for discharging the storage elements and adapted to enable a series circuit including at least some of the N electrical energy storage elements to be connected in parallel with the on-board network so that when the rapid reactivation system is in operation the electrical machine is powered by a voltage level higher than the voltage level of its nominal characteristics.

Abstract: A rolled stainless steel object has surface with a raised and indented pattern including a random juxtaposition of at least two types of polygons. Each of the polygons has at least three sides, and is made up of substantially parallel rectilinear scratches, having a depth of from 5 to 30 ?m separated by ridge lines, the axes of which are from 0.1 to 0.3 mm from each other, and a Fourier transform spectral analysis of which, carried out on a square of at least 100 mm2, shows that they have an isotropy of at least 40% between the rolling direction and the sideways direction, and two adjacent preferred angular orientations of which scratches, from among the three main preferred angular orientations thereof, are spaced apart by a minimum of 20° and a maximum of 60°.

Abstract: A structure establishing a sound insulator and including a first plate, a second plate having holes therethrough, and a web stuck between the plates. The web includes a plurality of intermediate strips perpendicular at least to one of the plates, a plurality of folded strips which are folded in a zig-zag formation, each folded strip being arranged between two successive intermediate strips, and establishes, with the intermediate strips, triangular prisms, where, for two folded strips on either side of a same intermediate strip, the generator of the triangular prism of one of the folded strips forms an acute angle with respect to the first plate, and the generator of the triangular prism of the other folded strip forms an obtuse angle with respect to the first plate.

Abstract: The invention relates to a method (100) for manufacturing a turbomachine fan comprising a plurality of blades mounted on a disc extending along a longitudinal axis, said method comprising the following steps of: —measuring (102) at least one structural parameter of each of the blades in the cold state, and, for each of the blades, estimating (103) at least one structural parameter in operation relating to a blade from the structural parameter(s) measured on said blade in the cold state, —determining (104) an optimal sequence of the blades around the disc from the structural parameters estimated in operation for each of the blades, and —mounting (105) the blades on the disc in the optimal sequence thus determined.

Abstract: The invention relates to laminated glazing comprising a substrate, in particular a transparent substrate, optionally coloured, coated with an infrared-reflecting layer and capable of being used as glazing in buildings or in vehicles. The coated substrate is made up of the combination of a glass substrate in which the composition has a redox of less than 15%, characterised by infrared reflection RIRV so that RIRV?1.087*TLV, wherein TLV is the light transmission of the glass, and an infrared reflecting layer characterised by light transmission TLC so that TLC?1.

Abstract: The invention relates to substrates, in particular to transparent substrates, optionally coloured, coated with an infrared-reflecting layer and capable of being used as glazing in buildings or in vehicles. Said coated substrates are made up of the combination of a glass substrate in which the composition has a redox of less than 15%, characterised by infrared reflection RIRV so that RIRV?1.087*TLV, wherein TLV is the light transmission of the glass, and an infrared reflecting layer characterised by light transmission TLC so that TLC?1.3*TIRC, wherein TIRC is the infrared transmission of the layer.

Abstract: The invention provides a sustained release intraocular drug delivery device comprising: (a) a polymeric matrix core into which at least one therapeutic agent is mixed, and; (b) a polymeric coating completely surrounding said polymeric matrix material; wherein said polymeric matrix core and polymeric coating are insoluble and inert in ocular fluids, and wherein said sustained release intraocular drug delivery device has a compliant annular segment shape and is to be inserted into the sulcus of the intact and/or pseudophakic eye.

Abstract: The invention provides molecules, e.g., antibodies or antibody fragments, that specifically bind thymic stromal lymphopoietin (TSLP), compositions comprising these molecules, and methods of using and producing these molecules.

Abstract: Methods and systems for protecting a duct joint are provided. An assembly for protecting a joint formed between a first duct and an adjacent second duct includes a first coupling element coupled about the first duct and a second coupling element coupled about the second duct. The assembly also includes a plurality of axial straps coupled between the first coupling element and the second coupling element such that each axial strap of the plurality of straps forms a loop that encircles a portion of each of the first coupling element and the second coupling element.

Abstract: A procedure is performed on at least one section of an ocular component. At least one first electro-magnetic radiation is provided to the section so as to interact with at least one acoustic wave in the ocular component. At least one second electro-magnetic radiation is produced based on the interaction. Multiple portions of the second electromagnetic radiation are received. Each portion was emitted from a different corresponding segment of the section. A visco-elastic modulus of the section is monitored based on the multiple portions during the procedure. Feedback is applied to the procedure based at least in part on the monitored visco-elastic modulus, including at least one of: (1) guiding a trajectory of an incision based on different respective monitored values of visco-elastic modulus for the segments, or (2) determining a number of incisions to be made based on different respective monitored values of visco-elastic modulus for the segments.

Abstract: The invention relates to a navigational aid method for an inertial navigation system including at least one inertial sensor (4) having a sensitive axis (X-X), each inertial sensor (4) comprising an ASG gyroscope (8) able to deliver an ASG signal representative of a rotation about the corresponding sensitive axis (X-X), and a MEMS gyroscope (10) able to deliver a MEMS signal representative of a rotation about the corresponding sensitive axis (X-X), the method including the steps of: between a first date and a subsequent third date, calculating a path from the MEMS signals; from the third date, calculating the path from the ASG signals; estimating a bias vector introduced by the MEMS gyroscopes (10), from the MEMS signals and ASG signals; at a fourth date subsequent to the third date, resetting the path.

Abstract: Operating a touch-screen device includes displaying at least a portion of a keyboard on a touch-screen, detecting a touch on the touch-screen, and detecting movement of the touch on the touch-screen. Operating the touch-screen device also includes moving the displayed keyboard in response to the detected movement of the touch on the touch-screen, detecting a release of the touch from the touch-screen, and assigning a character according to a final location of the touch relative to a location of the displayed keyboard.

Abstract: One or more embodiments disclosed herein are directed to a chip scale package camera module that includes a glass interposer between a lens and an image sensor. In some embodiments, the glass interposer is made from one or more layers of optical quality glass and includes an infrared filter coating. The glass interposer also includes electrically conductive paths to connect the image sensor, mounted on one side of the glass interposer, with other components such as capacitors, which may be mounted on a different side of the glass interposer, and the rest of the camera system. The conductive layers include traces and vias that are formed in the glass interposer in areas away from the path of light in the camera module, such that the traces and vias do not block the light between the lens and the image sensor.