Abstract: Novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Abstract: The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Abstract: Novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Abstract: The present invention relates to novel bis-indolic derivatives, processes for their preparation, and their potential use as new antibacterial drugs.

Abstract: Taxane derivatives and a method of preparing taxane derivatives of formula (I): 1

Abstract: Novel carboxylic acids of formula (VI), useful for preparing taxane derivatives of general formula (I) by esterifying protected baccatine (III) or protected diacetyl baccatin (III) with an acid of general formula (II). The products of general formula (I) are particularly useful for preparing taxol, Taxotere and analogs thereof having anti-tumor properties.

Abstract: A .beta.-phenylisoserine derivative of general formula (I): ##STR1## in the form of a salt or an ester, in which Ar represent an aryl radical, R represents a phenyl or naphthyl or a O--R.sub.1 radical and G.sub.1 represents --CH.sub.2 --Ph radical; and a method of using the same for making taxane derivatives.

Abstract: A compound of the formula I: ##STR1## wherein Ar represents an aryl radical;R.sub.1 represents a hydrogen atom, an aroyl radical, or a radical of the formula R.sub.4 --O--CO;R.sub.2 and R.sub.3 together form a 5- or 6-membered saturated heterocycle;G.sub.1 represents an acetyl radical or a protecting group of the hydroxyl functional group; andG.sub.2 represents a protecting group of the hydroxyl functional group.

Abstract: Method for the preparation of 1,3-oxazolidin 5-carboxylic acid having the general formula (I) ##STR1## from a product having the general formula (II) ##STR2## In the general formulas (I) and (II), Ar is an aryl radical, R.sub.1 is a benzoyl radical or a radical R.sub.2 --O--CO-- wherein R.sub.2 is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, bicycloalkyl, phenyl or heterocyclyl radical, Ph is an optionally substituted phenyl radical, X is the residue of an optically active organic base or an alkoxy radical optionally substituted by a phenyl radical. The acids of formulas (I) and (II) are particularly useful in preparing taxol, Taxotere or analogs thereof which have remarkable antitumor and antileukemia properties.

Abstract: This invention relates to a method of stereoselective preparation of a derivative of .beta.-phenylisoserine of formula (I) by the action of an N-carbonyl-benzylimine of formula (II) on an optically active amide of a protected hydroxyacetic acid of formula (III), followed by hydrolysis of the product obtained. In formula (I), (II) or (III), R is an optionally substituted phenyl radical or R.sub.1 --O, Ar is an optionally substituted aryl radical and G.sub.1 is a hydroxy function protection grouping. The product of formula (I) is particularly useful in preparing taxol and Taxotere which have remarkable antitumor properties.

Abstract: This invention relates to a method of preparing esters of baccatine III or 10-deacetylbaccatine III of formula (I) by esterification of protected baccatine III or 10-deacetylbaccatine III of formula (II) by means of an activated acid of formula (III). The esters of formula (I) can be used to prepare taxane derivatives having remarkable antileucemia and antitumor properties. In formulae (I), (II) and (III) Ar is an aryl radical, R.sub.1 is a hydrogen atom or an aryl radical or an R.sub.4 --O--CO-- radical (R.sub.4 =alkenyl, alkynyl, optionally substituted alkyl, cycloalkyl, cycloalkynyl, bicycloalkyl, phenyl, heterocyclyle) and R.sub.2 is a hydrogen atom, and R.sub.3 stands for a hydroxy function protection grouping, or R.sub.1 is defined as above and R.sub.2 and R.sub.3 together form a 5 or 6 membered, saturated heterocyclic ring, G.sub.1 is an acetyl radical or a hydroxy function protection grouping, G.sub.2 is a hydroxy function protection grouping, and X is an acyl radical, aryl, radical or halogen atom.

Abstract: A method for preparing taxane derivatives of general formula (I) by esterifying protected baccatin III or protected 10-deacetyl baccatin III with an acid of general formula (II). In general formulae (I) and (II), Ar is an aryl radical; R.sub.1 and R.sub.2 which are the same or different, are a hydrogen atom, an alkyl, phenylalkyl, phenyl, alkoxyphenyl or dialkoxyphenyl radical, or R.sub.1 or R.sub.2, together with the carbon atom to which they are attached, form a 4-7 membered ring; R.sub.3 is an acetyl radical or a hydroxy function protective grouping, and R.sub.4 is a hydroxy function protective grouping; R is a phenyl radical or a radical of formula R.sub.5 --O-- wherein R.sub.5 -- is an alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkenyl, phenyl or saturated or unsaturated nitrogenous heterocylcyl radical. The products of general formula (I) are particularly useful for preparing taxol, Taxotere and analogues thereof having remarkable antitumor properties.

Abstract: Process for the enantioselective preparation of phenylisoserine derivatives of general formula (I), in which R represents a phenyl or tert-butoxy radical, R.sub.1 represents a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms and R.sub.2 represents a hydrogen atom or a group protecting the alcohol function.

Abstract: Process for the enantioselective preparation of phenylisoserine derivatives of general formula (I), in which R represents a phenyl or tert-butoxy radical, R.sub.1 represents a hydrogen atom or an alkyl radical containing 1 to 4 carbon atoms and R.sub.2 represents a hydrogen atom or a group protecting the alcohol function.

Abstract: Process for the enantioselective preparation of phenylisoserine derivatives of general formula (I) ##STR1## from phenylglycine S(+) wherein R is a phenyl radical or a tert butoxy radical and R is an alcohol protective group.

Abstract: A stereoselective process for preparing phenylisoserine derivatives is disclosed. Benzylamine is reacted with an agent for introducing a phenyl or a t-butoxycarbonyl group. The product undergoes double anionization and then is reacted with acrolein to provide a mixture of alcohol syn and anti diasteroisomers. The syn isomer is isolated by chromatography. Whereupon, the hydroxyl is protected and the product is oxidized to provide the phenylisoserine derivative.

Abstract: Process for preparing taxol by the condensation of a (2R, 3S) acid of general formula (I) with a taxan derivative of general formula (II), followed by the removal of the groups R.sub.2 and R.sub.3 protecting the hydroxy groups.

Abstract: Process for preparing taxol by the condensation of a (2R, 3S) acid of general formula (I) with a taxan derivative of general formula (II), followed by the removal of the groups R.sub.2 and R.sub.3 protecting the hydroxy groups .Iadd.and intermediates used therein.Iaddend..