Patents by Inventor Jean P. Klein

Jean P. Klein has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Conjugate constituted from a wall adhesin of S. mutans of proteinic nature and from a polysaccharide of S. mutans, its preparation and its use particularly in anti-caries vaccines
    Patent number: 4789735
    Abstract: The conjugate according to the invention is constituted by a wall adhesin of Streptococcus mutans, of a proteinic nature, capable of binding the components of saliva, or an active fraction of such a protein, covalently coupled to a Streptococcus mutans polysaccharide, or to a fraction of such a polysaccharide.Preferably, the adhesin is constituted by a single polypeptide chain having a molecular weight of about 74,000; it is common to the different serotypes of Streptococcus mutans where it has a crossed antigenicity; and it is capable of interacting with the salivary glycoproteins and polysaccharide derived from the same serotype of S. mutans, particularly serotype f.Use for the preparation of immunogenic compositions, particularly for the preparation of vaccines against dental caries.
    Type: Grant
    Filed: May 13, 1986
    Date of Patent: December 6, 1988
    Assignees: Universite Catholique de Louvain, Institut National de la Sante et de la Recherche Medicale
    Inventors: Robert Frank, Jean P. Klein, Fabienne Ackermans, Herve Bazin