Patents by Inventor Jean P. Wiley

Jean P. Wiley has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Sensor surfaces for detecting analytes
    Patent number: 7208322
    Abstract: The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The matrix is preferably a self-assembled monolayer (SAM), a mixed self-assembled monolayer (mSAM), or combinations thereof.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: April 24, 2007
    Assignee: Agilent Technologies, Inc.
    Inventors: Mark L. Stolowitz, Jean P. Wiley, Guisheng Li, Kevin Lund
  • Sensor surfaces for detecting analytes and methods of use
    Patent number: 7179659
    Abstract: The present invention provides a method for detecting an analyte, comprising providing a sensor comprising a substrate coated with a free electron metal, a matrix layer disposed on the free electron metal, the matrix layer comprising an organic compound, wherein the organic compound has a boronic acid complexing moiety and, a boronic acid moiety complexed to the boronic acid complexing moiety; and contacting the sensor with the analyte to elicit a response; and measuring the response thereby detecting the analyte.
    Type: Grant
    Filed: April 2, 2002
    Date of Patent: February 20, 2007
    Assignee: Agilent Technologies, Inc.
    Inventors: Mark L. Stolowitz, Jean P. Wiley, Guisheng Li, Kevin Lund
  • 1,2-Phenylenediboronic acid reagents and complexes
    Patent number: 6630577
    Abstract: A reagent having the general formula of General Formula I: wherein group Z comprises a spacer selected from an aliphatic chain up to about 6 carbon equivalents in length, an unbranched aliphatic chain of from about 6 to 18 carbon equivalents in length with at least one of an intermediate amide and a disulfide moiety, and a polyethylene glycol chain of from about 3 to 12 carbon equivalents in length; wherein group R is an electrophilic or nucleophilic moiety suitable for reaction of the reagent with a biologically active species; and wherein group Q is one of nothing at all, an amide, a methyl amide, a methylene, an ether, a thioether, a methyl ether, and a methyl thioether moiety. Also, a conjugate, a bioconjugate and a method of conjugating.
    Type: Grant
    Filed: June 4, 2001
    Date of Patent: October 7, 2003
    Assignee: Prolinx, Inc.
    Inventors: Mark L. Stolowitz, Guisheng Li, Jean P. Wiley
  • Sensor surfaces for detecting analytes and methods of use
    Publication number: 20030032202
    Abstract: The present invention provides a method for detecting an analyte, comprising providing a sensor comprising a substrate coated with a free electron metal, a matrix layer disposed on the free electron metal, the matrix layer comprising an organic compound, wherein the organic compound has a boronic acid complexing moiety and, a boronic acid moiety complexed to the boronic acid complexing moiety; and contacting the sensor with the analyte to elicit a response; and measuring the response thereby detecting the analyte.
    Type: Application
    Filed: April 2, 2002
    Publication date: February 13, 2003
    Applicant: Prolinx Incorporated
    Inventors: Mark L. Stolowitz, Jean P. Wiley, Guisheng Li, Kevin Lund
  • Sensor surfaces for detecting analytes
    Publication number: 20020192722
    Abstract: The present invention provides a sensor surface comprising: a substrate coated with a free electron metal; and a matrix layer disposed on the free electron metal, wherein the matrix layer comprises an organic compound having a boronic acid complexing moiety. The matrix is preferably a self-assembled monolayer (SAM), a mixed self-assembled monolayer (mSAM), or combinations thereof.
    Type: Application
    Filed: April 2, 2002
    Publication date: December 19, 2002
    Applicant: Prolinx Incorporated
    Inventors: Mark L. Stolowitz, Jean P. Wiley, Guisheng Li, Kevin Lund
  • 1,2-phenylenediboronic acid reagents and complexes
    Publication number: 20020038004
    Abstract: A reagent having the general formula of General Formula I: 1
    Type: Application
    Filed: June 4, 2001
    Publication date: March 28, 2002
    Inventors: Mark L. Stolowitz, Guisheng Li, Jean P. Wiley