Abstract: Enzymes are fixed to cellulose containing 5 to 25% lignin to form an enzyme-cellulose complex by a process involving treating cellulose pieces with an alkaline solution to remove lignin on the surface of the pieces, treating the resultant cellulose pieces with a sulfochlorinating or a chlorinating agent in an excess of pyridine until sulfur and/or chlorine is combined with the cellulose, washing the sulfur and/or chlorine-containing cellulose pieces and treating the pieces with an aqueous enzyme solution to attach enzymes thereto. A very important application is preparation of a rennet-cellulose complex and using the complex for coagulating milk in making cheese.