Abstract: A pharmaceutical composition suitable for the treatment of cardiovascular disorders is described which comprises an inhibitor of the Renin Angiotensin System and an endothelin antagonist.

Abstract: Pharmaceutical composition comprising a tetrahydronaphthalene derivative of the formula ##STR1## wherein R.sup.1 is halogen, R.sup.2 is lower-alkoxy-lower-alkylcarbonyloxy, X is C.sub.2 -C.sub.8 -alkylene and A is benzimidazolyl optionally substituted at the N atom by alkyl with 1 to 12 C atoms,and a pyridazodiazepine of the formula ##STR2## wherein R.sup.4 is aralkyl with 1 to 6 C atoms in the alkyl residue and phenyl, which is optionally mono-substituted by halogen, alkoxy with 1 to 6 C atoms or phenyl, as the aryl residue, R.sup.5 and R.sup.6 each independently are hydrogen or alkyl with 1 to 6 C atoms and R.sup.7 and R.sup.8 each are hydrogen or together are an oxo group,in the form of their free bases, their hydrates or their pharmaceutically usable salts for the simultaneous, separate or planned stepwise use in the control or prevention of circulatory disorders, especially hypertension.