Abstract: The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure trans-cyclopropane carboxylic acid derivatives, processes for preparing the carboxylic acid derivatives and their use in preparing pharmaceuticals.

Abstract: The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure trans-cyclopropane carboxylic acid derivatives, processes for preparing the carboxylic acid derivatives and their use in preparing pharmaceuticals.

Abstract: The present invention relates to compounds useful as pharmaceutical intermediates, to processes for preparing the intermediates, to intermediates used in the processes, and to the use of the intermediates in the preparation of pharmaceuticals. In particular, the present invention concerns enantiomerically pure trans-cyclopropane carboxylic acid derivatives, processes for preparing the carboxylic acid derivatives and their use in preparing pharmaceuticals.

Abstract: The subject of the present invention is conjugates of vinca (indole-dihydroindole) derivatives carrying a detergent chain of at least 7 aliphatic carbon atoms in the C-3 position bonded via a covalent bond to a macromolecular carrier of polypeptide character, and also pharmaceutical compositions containing these conjugates and a process of preparation.

Abstract: The invention relates to new conjugates of vinblastine and some of its known derivatives with proteins, fragments thereof, aminoacids or amines, which are useful as anti-tumor agents. The invention also relates to some intermediates which are active in chemotherapy, and amino derivatives thereof.These compounds correspond to the following general formula ##STR1## in which A represents an acetylamino-, trifluoroacetylamino- or carbobenzyloxyamino- substituted --CO(CH.sub.2).sub.n CO-- or ##STR2## in which n is 1 to 5, R.sub.1 represents an optionally modified protein radical,R.sub.2 represents a methoxy group, an amino group or an alpha-aminoacid ester radical which is bonded via a bond of the amide type and in which the ester group contains 1 to 6 carbon atoms, and R.sub.3 represents hydrogen or hydroxyl.

Abstract: The invention relates to vinca (indole-dihydroindole) alkaloid derivatives, in which a fatty chain containing at least 7 aliphatic carbon atoms is present at least at the C.sup.3 /C.sup.4 -position.The derivatives according to the present invention are useful as drugs.

Abstract: The invention is related to new 1,2,3,4,5,6-hexahydro-5-hydroyalkylazepino[4,5-b]-indole derivatives, of formula: ##STR1## in which R.sub.1 denotes a hydrogen atom, an alkyl radical, an alkenyl radical, a benzyl radical, an alkylamino radical of the type ##STR2## where the groups R' are either hydrogen atoms or alkyl radicals or form, together with the nitrogen atom to which they are attached, a heterocyclic nucleus of the morpholinyl, piperidinyl, pyrrolidinyl or piperazinyl type, and m is 2 or 3,R.sub.2 denotes a hydrogen atom or a benzoyl or acyl radical,R.sub.3 denotes a hydrogen atom or an alkyl or benzyl radical,R.sub.4 denotes a hydrogen or halogen atom, an alkyl radical an alkoxy radical or a trifluoromethyl radical, andn is 1 or 2, and the salts of addition to pharmaceutically acceptable acids,and to process for their preparation, to intermediates obtained and to their therapeutical use in treating mental disorders.