Patents by Inventor Jean-Paul Di Rago

Jean-Paul Di Rago has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • COMPOUNDS FOR THE TREATMENT OF MITOCHONDRIAL DISEASES
    Publication number: 20120329834
    Abstract: The present invention relates to the use of compounds of general formula (I): (I) for the preparation of medicaments that act against mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as mitochondrial diseases.
    Type: Application
    Filed: April 15, 2010
    Publication date: December 27, 2012
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSITY OF PITTSBURGH, INSTITUT CURIE
    Inventors: Marc Blondel, Elodie Couplan, Jean-Paul Di Rago, Daniel Dauzonne, Michael Palladino, Alicia Celotto
  • Modelling in yeast of the mitochondrial gene mutations responsible for NARP syndrome in humans and uses thereof for screening for medicaments
    Patent number: 8211690
    Abstract: Modified yeast cells comprising at least one mutation of the tryptophan 136 (W136), leucine 183 (L183), or leucine 247 (L247) codon of the mitochondrial ATP6 gene, responsible for NARP syndrome in humans and uses thereof for screening for medicaments that act against mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as NARP syndrome.
    Type: Grant
    Filed: May 3, 2007
    Date of Patent: July 3, 2012
    Assignees: Universite Victor Segalen Bordeaux 2, Centre National de la Recherche Scientifique
    Inventors: Jean-Paul Di Rago, Malgorzata Rak, Roza Kucharczyk, Emmanuel Tetaud, Stephane Duvezin-Caubet
  • Industrial method for producing RNA and system for carrying out said method
    Patent number: 8143061
    Abstract: The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription vector comprising at least one copy of the DNA encoding said interest heterologous RNA which are controlled by regulatory element(s) of the mitochondrial transcription and a reporter gene thereof or a fragment of said reporter gene, 2) identifying yeast transformants by incorporating the interest DNA into the mitochondrions thereof, (3) culturing the yeast mitochondrial transformants selected at the stage (2), (4) isolating the mitochondrions from the yeast mitochondrial transformants obtainable at stages (3) and in extracting and purifying the interest heterologous RNA from said mitochondrions.
    Type: Grant
    Filed: July 22, 2004
    Date of Patent: March 27, 2012
    Assignees: Centre National de la Recherche Scientifique, Universite Victor Segalen Bordeaux 2
    Inventors: Jean-Paul Di Rago, Nathalie Bonnefoy, Stéphane Duvezin-Caubet
  • MODELLING IN YEAST OF THE MITOCHONDRIAL ATP6 GENE MUTATIONS RESPONSIBLE FOR NARP SYNDROME IN HUMANS AND USES THEREOF FOR SCREENING FOR MEDICAMENTS
    Publication number: 20100021955
    Abstract: Modified yeast cells comprising at least one mutation of the tryptophan 136 (W136), leucine 183 (L183), or leucine 247 (L247) codon of the mitochondrial ATP6 gene, responsible for NARP syndrome in humans and uses thereof for screening for medicaments that act against mitochondrial pathologies involving a deficiency in ATP production via the oxidative phosphorylation pathway, such as NARP syndrome.
    Type: Application
    Filed: May 3, 2007
    Publication date: January 28, 2010
    Applicants: UNIVERSITE VICTOR SEGALEN BORDEAUX 2, CENTRE NAT DE LA RECHERCHE SCIENTIFIQUE
    Inventors: Jean-Paul Di Rago, Malgorzata Rak, Roza Kucharczyk, Emmanuel Tetaud, Stephane Duvezin-Caubet
  • Industrial method for producing rna and system for carrying out said method
    Publication number: 20070072272
    Abstract: The invention relates to an industrial method for producing an interest heterologous RNA and to a system for carrying out said production method consisting (1) in transforming mitochondrions of yeast cells free of mitochondrial RNA with a mitochondrial transcription vector comprising at least one copy of the DNA encoding said interest heterologous RNA which are controlled by regulatory element(s) of the mitochondrial transcription and a reporter gene thereof or a fragment of said reporter gene, 2) identifying yeast transformants by incorporating the interest DNA into the mitochondrions thereof, (3) culturing the yeast mitochondrial transformants selected at the stage (2), (4) isolating the mitochondrions from the yeast mitochondrial transformants obtainable at stages (3) and in extracting and purifying the interest heterologous RNA from said mitochondrions.
    Type: Application
    Filed: July 22, 2004
    Publication date: March 29, 2007
    Applicants: CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, UNIVERSTITE VICTOR SEGALEN
    Inventors: Jean-Paul Di Rago, Nathalie Bonnefoy, Stephane Duvezin-Caubet