Patents by Inventor Jean-Paul Vevert

Jean-Paul Vevert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).

  • Patent number: 6143774
    Abstract: The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl, optionally substituted or cycloalkyl optionally interrupted by heteroatoms,R.sub.2 ; R.sub.3 both represent or carry an acid function or an acid isosteric function,and Y represents phenyl substituted in particular by a dioxol radical,these products being in all the isomeric forms and the salts, as medicaments.
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: November 7, 2000
    Assignee: Hoechst Marion Roussel
    Inventors: Bertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5986103
    Abstract: The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl,A represents a sulphur or oxygen atom,R.sub.2 represents carboxy, tetrazolyl or alkyl, alkoxy, alkylthio substituted by a carboxy or a tetrazolyl,Hal.sub.1 is halogen, q represents an integer from 0 to 4,R.sub.3 is formyl, carboxy or tetrazolyl,Y represents phenyl substituted by a dioxol radical and optionally by a halogen atom, or by an alkyl or alkoxy radicalas well as all the possible racemic, enantiomeric and diastereoisomeric isomer forms, as well as the addition salts of said products of formula (I).
    Type: Grant
    Filed: June 9, 1998
    Date of Patent: November 16, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Bertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5932741
    Abstract: The invention relates to the use and the products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(o).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl,and Y represents optionally substituted aryl,these products being in all the isomer forms and the salts, as medicaments.
    Type: Grant
    Filed: June 29, 1998
    Date of Patent: August 3, 1999
    Assignee: Hoechst Marion Roussel
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5856509
    Abstract: The invention relates to the products of formula (I): ##STR1## in which: R.sub.1 =represents hydrogen, aryl, arylcarbonyl, arylthio, alkylcarbonyl,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--,and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all isomer forms and salts, their use as medicaments.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: January 5, 1999
    Assignee: Roussel Uclaf
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5811444
    Abstract: The invention relates to the new use and the new products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all the isomer forms and the salts, as medicaments.
    Type: Grant
    Filed: January 31, 1997
    Date of Patent: September 22, 1998
    Assignee: Roussel Uclaf
    Inventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
  • Patent number: 5714508
    Abstract: Described herein are compounds of the formula ##STR1## wherein the substituents are defined as in the specification having inhibiting activity on the effects of angiotensin II.
    Type: Grant
    Filed: August 1, 1994
    Date of Patent: February 3, 1998
    Assignee: Roussel Uclaf
    Inventors: Alain Corbier, Jean Paul Vevert, Jidong Zhang
  • Patent number: 5691347
    Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.
    Type: Grant
    Filed: April 20, 1995
    Date of Patent: November 25, 1997
    Assignee: Roussel Uclaf
    Inventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
  • Patent number: 5684028
    Abstract: Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of angiotensin II in warm-blooded animals.
    Type: Grant
    Filed: October 9, 1996
    Date of Patent: November 4, 1997
    Assignee: Roussel UCLAF
    Inventors: Jean Claude Caille, Alain Corbier, Michel Fortin, Gilles Hamon, Simone Jouquey, Jean Paul Vevert
  • Patent number: 5650414
    Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.
    Type: Grant
    Filed: March 7, 1995
    Date of Patent: July 22, 1997
    Assignee: Roussel Uclaf
    Inventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
  • Patent number: 5482957
    Abstract: Azole derivatives, process for their preparation, and their useAzole derivatives of the formula (I) ##STR1## in which A, L, O, R.sup.1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have for example the following meanings:R.sup.1 is (C.sub.2 -C.sub.10)-alkyl,Z is nitrogen,X and Y are independently of one another CR.sup.2,L is --CH.sub.2 --,q is zero or 1,A is a biphenyl radical which is substituted for example by R.sup.15,R.sup.2 is halogen or hydrogen,R.sup.15 is SO.sub.2 --NH--CO--OR.sup.6 andR.sup.6 is phenyl,are highly active antagonists of angiotensin II receptors.
    Type: Grant
    Filed: April 28, 1994
    Date of Patent: January 9, 1996
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Heinrich Englert, Heinz-Werner Kleemann, Hermann Gerhards, Bernward Scholkens, Reinhard Becker, Wolfgang Linz, Jean-Paul Vevert, John-Claude Caille
  • Patent number: 5474996
    Abstract: Novel pyrimidine derivatives of the formula ##STR1## represents: either a group: ##STR2## or a group: ##STR3## having angiotensin II inhibiting activity.
    Type: Grant
    Filed: May 22, 1992
    Date of Patent: December 12, 1995
    Assignee: Roussel Uclaf
    Inventors: Jean-Claude Caille, Stanislas Didierlaurent, Jean-Paul Vevert
  • Patent number: 5470867
    Abstract: Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
    Type: Grant
    Filed: October 17, 1994
    Date of Patent: November 28, 1995
    Assignee: Roussel-Uclaf
    Inventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
  • Patent number: 5440046
    Abstract: The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.
    Type: Grant
    Filed: May 27, 1994
    Date of Patent: August 8, 1995
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Rainer Henning, Hermann Gerhards, Bernward Scholkens, Jean-Paul Vevert, Jean-Claude Caille
  • Patent number: 5420138
    Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.
    Type: Grant
    Filed: January 29, 1993
    Date of Patent: May 30, 1995
    Assignee: Roussel-UCLAF
    Inventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
  • Patent number: 5389634
    Abstract: Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
    Type: Grant
    Filed: June 9, 1993
    Date of Patent: February 14, 1995
    Assignee: Roussel-Uclaf
    Inventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
  • Patent number: 5350751
    Abstract: The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, R.sup.1 and R.sup.2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.
    Type: Grant
    Filed: April 2, 1991
    Date of Patent: September 27, 1994
    Assignee: Hoechst Aktiengesellschaft
    Inventors: Adalbert Wagner, Rainer Henning, Hermann Gerhards, Bernward Scholkens, Jean-Paul Vevert, Jean-Claude Caille
  • Patent number: 5338756
    Abstract: Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.
    Type: Grant
    Filed: June 7, 1991
    Date of Patent: August 16, 1994
    Assignee: Roussel Uclaf
    Inventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
  • Patent number: 5098934
    Abstract: Novel .omega.-mercaptopropanamides and their homologs of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, alkyl and alkoxy of 1 to 5 carbon atoms, --NO.sub.2 and halogen, n is an integer from 1 to 5, R.sub.2 is selected from the group consisting of hydrogen alkyl of 1 to 5 carbon atoms and aryl and aralkyl of 6 to 15 carbon atoms optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.3 is selected from the group consisting of a) hydrogen, b) phenyl optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, halogen, --CF.sub.
    Type: Grant
    Filed: June 22, 1990
    Date of Patent: March 24, 1992
    Assignee: Roussel Uclaf
    Inventors: Jean-Paul Vevert, Francoise Delevallee, Rogert Deraedt
  • Patent number: 4839358
    Abstract: Novel .alpha.-mercaptomethyl-benzene propanamides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, --NO.sub.2, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.2 is selected from the group consisting of pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrahydrothiazinyl and hexahydroazepinyl, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, --CF.sub.
    Type: Grant
    Filed: February 23, 1988
    Date of Patent: June 13, 1989
    Assignee: Roussel Uclaf
    Inventors: Jean-Paul Vevert, Francoise Delevallee, Jean-Claude Gasc, Francis Petit