Patents by Inventor Jean-Paul Vevert
Jean-Paul Vevert has filed for patents to protect the following inventions. This listing includes patent applications that are pending as well as patents that have already been granted by the United States Patent and Trademark Office (USPTO).
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Patent number: 6143774Abstract: The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl, optionally substituted or cycloalkyl optionally interrupted by heteroatoms,R.sub.2 ; R.sub.3 both represent or carry an acid function or an acid isosteric function,and Y represents phenyl substituted in particular by a dioxol radical,these products being in all the isomeric forms and the salts, as medicaments.Type: GrantFiled: June 9, 1998Date of Patent: November 7, 2000Assignee: Hoechst Marion RousselInventors: Bertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
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Patent number: 5986103Abstract: The invention relates to the new products of formula (I): ##STR1## in which: R.sub.1 represents alkyl,A represents a sulphur or oxygen atom,R.sub.2 represents carboxy, tetrazolyl or alkyl, alkoxy, alkylthio substituted by a carboxy or a tetrazolyl,Hal.sub.1 is halogen, q represents an integer from 0 to 4,R.sub.3 is formyl, carboxy or tetrazolyl,Y represents phenyl substituted by a dioxol radical and optionally by a halogen atom, or by an alkyl or alkoxy radicalas well as all the possible racemic, enantiomeric and diastereoisomeric isomer forms, as well as the addition salts of said products of formula (I).Type: GrantFiled: June 9, 1998Date of Patent: November 16, 1999Assignee: Hoechst Marion RousselInventors: Bertrand Heckmann, Simone Jouquey, Jean-Paul Vevert, Jidong Zhang
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Patent number: 5932741Abstract: The invention relates to the use and the products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(o).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl,and Y represents optionally substituted aryl,these products being in all the isomer forms and the salts, as medicaments.Type: GrantFiled: June 29, 1998Date of Patent: August 3, 1999Assignee: Hoechst Marion RousselInventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
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Patent number: 5856509Abstract: The invention relates to the products of formula (I): ##STR1## in which: R.sub.1 =represents hydrogen, aryl, arylcarbonyl, arylthio, alkylcarbonyl,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--,and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all isomer forms and salts, their use as medicaments.Type: GrantFiled: January 31, 1997Date of Patent: January 5, 1999Assignee: Roussel UclafInventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
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Patent number: 5811444Abstract: The invention relates to the new use and the new products of formula (I): ##STR1## in which: R.sub.1 =represents hydroxyl, alkyl, alkenyl, alkynyl, alkoxy, alkylthio, formyl, cycloalkyl, optionally interrupted by heteroatoms,R.sub.2, R.sub.3 represent in particular halogen, mercapto, acyl, carboxy, nitro, cyano, amino, carbamoyl, R.sub.4, --OR.sub.4 with R.sub.4 representing in particular hydrogen, alkyl, alkenyl, alkynyl, acyl, amino, --(CH.sub.2).sub.m1 --S(O).sub.m2 --X--R.sub.10 with m1=0 to 4, m2=0 to 2, X represents a single bond or --NH--, --NH--CO--, --NH--CO--NH--, and R.sub.10 represents alkyl, alkenyl or aryl, and Y represents optionally substituted aryl, these products being in all the isomer forms and the salts, as medicaments.Type: GrantFiled: January 31, 1997Date of Patent: September 22, 1998Assignee: Roussel UclafInventors: Bertrand Heckmann, Jean-Paul Vevert, Jidong Zhang
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Patent number: 5714508Abstract: Described herein are compounds of the formula ##STR1## wherein the substituents are defined as in the specification having inhibiting activity on the effects of angiotensin II.Type: GrantFiled: August 1, 1994Date of Patent: February 3, 1998Assignee: Roussel UclafInventors: Alain Corbier, Jean Paul Vevert, Jidong Zhang
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Patent number: 5691347Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.Type: GrantFiled: April 20, 1995Date of Patent: November 25, 1997Assignee: Roussel UclafInventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
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Patent number: 5684028Abstract: Novel compounds of the formula ##STR1## wherein the, substituents are defined as in the specification and their non-toxic, pharmaceutically acceptable salts which inhibit the effects of angiotensin II in warm-blooded animals.Type: GrantFiled: October 9, 1996Date of Patent: November 4, 1997Assignee: Roussel UCLAFInventors: Jean Claude Caille, Alain Corbier, Michel Fortin, Gilles Hamon, Simone Jouquey, Jean Paul Vevert
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Patent number: 5650414Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.Type: GrantFiled: March 7, 1995Date of Patent: July 22, 1997Assignee: Roussel UclafInventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
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Patent number: 5482957Abstract: Azole derivatives, process for their preparation, and their useAzole derivatives of the formula (I) ##STR1## in which A, L, O, R.sup.1, X, Y, Z and q have the meanings given, process for their preparation, pharmaceutical preparations and the use of the compounds are described. Azole derivatives of the formula I where the symbols have for example the following meanings:R.sup.1 is (C.sub.2 -C.sub.10)-alkyl,Z is nitrogen,X and Y are independently of one another CR.sup.2,L is --CH.sub.2 --,q is zero or 1,A is a biphenyl radical which is substituted for example by R.sup.15,R.sup.2 is halogen or hydrogen,R.sup.15 is SO.sub.2 --NH--CO--OR.sup.6 andR.sup.6 is phenyl,are highly active antagonists of angiotensin II receptors.Type: GrantFiled: April 28, 1994Date of Patent: January 9, 1996Assignee: Hoechst AktiengesellschaftInventors: Adalbert Wagner, Heinrich Englert, Heinz-Werner Kleemann, Hermann Gerhards, Bernward Scholkens, Reinhard Becker, Wolfgang Linz, Jean-Paul Vevert, John-Claude Caille
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Patent number: 5474996Abstract: Novel pyrimidine derivatives of the formula ##STR1## represents: either a group: ##STR2## or a group: ##STR3## having angiotensin II inhibiting activity.Type: GrantFiled: May 22, 1992Date of Patent: December 12, 1995Assignee: Roussel UclafInventors: Jean-Claude Caille, Stanislas Didierlaurent, Jean-Paul Vevert
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Patent number: 5470867Abstract: Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.Type: GrantFiled: October 17, 1994Date of Patent: November 28, 1995Assignee: Roussel-UclafInventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
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Patent number: 5440046Abstract: The invention relates to compounds of the formula ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof for angiotensin II receptors.Type: GrantFiled: May 27, 1994Date of Patent: August 8, 1995Assignee: Hoechst AktiengesellschaftInventors: Adalbert Wagner, Rainer Henning, Hermann Gerhards, Bernward Scholkens, Jean-Paul Vevert, Jean-Claude Caille
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Patent number: 5420138Abstract: The bicyclic derivatives of pyridines of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts and a process and intermediates for their preparation which compounds are inhibitors of angiotensin II effects, particularly a vasoconstrictor activity.Type: GrantFiled: January 29, 1993Date of Patent: May 30, 1995Assignee: Roussel-UCLAFInventors: Alain Corbier, Michel Fortin, Jacques Guillaume, Jean-Luc Haesslein, Jean-Paul Vevert
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Patent number: 5389634Abstract: Imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.Type: GrantFiled: June 9, 1993Date of Patent: February 14, 1995Assignee: Roussel-UclafInventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
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Patent number: 5350751Abstract: The invention relates to compounds of the formula I ##STR1## in which X, Y and Z are identical or different and are N or CR.sup.2, R.sup.1 and R.sup.2 are as defined in the description, L is an alkylene radical, q is 0 or 1, and A is the radical of a fused heterobicyclic compound. The invention furthermore relates to a process for preparing the said compounds, agents containing these, and the use thereof in the treatment of high blood pressure.Type: GrantFiled: April 2, 1991Date of Patent: September 27, 1994Assignee: Hoechst AktiengesellschaftInventors: Adalbert Wagner, Rainer Henning, Hermann Gerhards, Bernward Scholkens, Jean-Paul Vevert, Jean-Claude Caille
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Patent number: 5338756Abstract: Novel imidazoles of the formula ##STR1## and their non-toxic, pharmaceutically acceptable salts with acids and bases having an antagonistic activity against angiotensin II receptors.Type: GrantFiled: June 7, 1991Date of Patent: August 16, 1994Assignee: Roussel UclafInventors: Michel Fortin, Daniel Frechet, Gilles Hamon, Simone Jouquey, Jean-Paul Vevert
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Patent number: 5098934Abstract: Novel .omega.-mercaptopropanamides and their homologs of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, alkyl and alkoxy of 1 to 5 carbon atoms, --NO.sub.2 and halogen, n is an integer from 1 to 5, R.sub.2 is selected from the group consisting of hydrogen alkyl of 1 to 5 carbon atoms and aryl and aralkyl of 6 to 15 carbon atoms optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.3 is selected from the group consisting of a) hydrogen, b) phenyl optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, halogen, --CF.sub.Type: GrantFiled: June 22, 1990Date of Patent: March 24, 1992Assignee: Roussel UclafInventors: Jean-Paul Vevert, Francoise Delevallee, Rogert Deraedt
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Patent number: 4839358Abstract: Novel .alpha.-mercaptomethyl-benzene propanamides of the formula ##STR1## wherein R.sub.1 is selected from the group consisting of hydrogen and ##STR2## R.sub.1 ' is selected from the group consisting of alkyl of 1 to 5 carbon atoms and aryl optionally substituted with at least one member of the group consisting of --OH, --NO.sub.2, halogen and alkyl and alkoxy of 1 to 5 carbon atoms, X and X' are individually selected from the group consisting of hydrogen, alkyl and alkoxy of 1 to 5 carbon atoms, --OH, halogen and --CF.sub.3, R.sub.2 is selected from the group consisting of pyrrolidinyl, morpholinyl, piperidinyl, piperazinyl, tetrahydrothiazinyl and hexahydroazepinyl, all optionally substituted with at least one member of the group consisting of alkyl and alkoxy of 1 to 5 carbon atoms, --OH, --NO.sub.2, --CF.sub.Type: GrantFiled: February 23, 1988Date of Patent: June 13, 1989Assignee: Roussel UclafInventors: Jean-Paul Vevert, Francoise Delevallee, Jean-Claude Gasc, Francis Petit